Search results for " INFLAMMATION"

Evolution and Immune Function of Fish Lectins

2016

Abstract Lectins are sugar-binding proteins widely distributed among animals, plants, and microbial taxon, involved in diverse biological processes. In both invertebrates and vertebrates, they play key roles in nonself recognition and immune responses, such as nonself recognition, inflammatory processes, and immunomodulation. In fish, many lectin families have been identified, and their tissue-specific expression and localization of the various lectin repertoires and their ligands are consistent with their distinct biological roles in innate and adaptive immunity. Here, we discuss the involvement of F-type lectins, rhamnose-binding lectins, galectins, and C-type lectins in pathogen recognit…

Vazodilatācijas intensitātes un insulīna rezistences rādītāju saistība ar endoteliālo (dis)funkciju raksturojošo signālmolekulu koncentrācijām hronis…

2013

ANOTĀCIJA Pētījuma mērķis ir noskaidrot smēķēšanas ierosināta iekaisuma un oksidatīvā stresa ietekmi uz insulīna rezistences un endotēlija disfunkcijas attīstību un to savstarpējo sakarību. Pētījumā piedalījās 128 dalībnieki (starp kuriem 52 personām konstatējām dislipidēmiju), kuriem tika noteiktas ar endotēlija funkcijām saistītu signālmolekulu seruma koncentrācijas, vazodilatācijas intensitāte ādas mikrocirkulācijā un insulīna rezistenci raksturojoši rādītāji. Rezultāti parādīja, ka smēķēšanas kumulatīvais efekts būtiski sekmē insulīna rezistences attīstību personām ar dislipidēmiju, bet smēķēšanas akūtais efekts caur iekaisuma signālmolekulām īslaicīgi samazina šūnu insulīna jutību neat…

Proton-irradiated breast cells: molecular points of view

2019

Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…

A multipronged approach to unveil the emerging role of Hsp60 in chronic obstructive pulmonary disease

2011

Inflammation is a major component of chronic obstructive pulmonary disease (COPD) and its cause and mechanisms are still incompletely understood. For example, the role of heat shock proteins (Hsps), many of which are molecular chaperones, has not been explored in detail in COPD, despite the fact that these molecules are known to participate in inflammation in other diseases. It has been shown that extracellular Hsps can signal certain types of T cells, macrophages, dendritic cells, and neutrophils and, thereby, elicit inflammation and immunity. However, these phenomena have not been investigated in COPD despite: a) the increasing awareness of Hsp participation in inflammation and immunity; …

Reduction Of Pulmonary Inflammation Through HIV-1 Envelope Protein GP120 In A Humanized Mouse Model Of Allergic Asthma Depends On Regulatory T Cells

2011

Analysis Of Pulmonary Inflammation Using Humanized Mouse Models

2010

Type 2-High and Type 2-Low Airway Inflammation in Severe Asthma

2019

Dataset related to article "Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs"

2021

This record contains data related to article: ""Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs". Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and to hinder the effectiveness of anticancer treatments. Of note, in response to IFNγ, M-MDSCs release the tumor-promoting and immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found that tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation of p50 NF-…

Asymptomatic carotid lesion as marker of future cerebrovascular and cardiovascular events in the follow-up: correlation with markers of inflammation …

2002

Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention

2020

Abstract Arabinogalactan, a microheterogeneous polysaccharide occurring in plants, is known for its allergy‐protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy‐protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subse…