Search results for " INTERPRETATION"
showing 10 items of 555 documents
ideal: an R/Bioconductor package for interactive differential expression analysis
2020
AbstractBackgroundRNA sequencing (RNA-seq) is an ever increasingly popular tool for transcriptome profiling. A key point to make the best use of the available data is to provide software tools that are easy to use but still provide flexibility and transparency in the adopted methods. Despite the availability of many packages focused on detecting differential expression, a method to streamline this type of bioinformatics analysis in a comprehensive, accessible, and reproducible way is lacking.ResultsWe developed the ideal software package, which serves as a web application for interactive and reproducible RNA-seq analysis, while producing a wealth of visualizations to facilitate data interpr…
Physics, Techniques and Review of Neuroradiological Applications of Diffusion Kurtosis Imaging (DKI)
2016
In recent years many papers about diagnostic applications of diffusion tensor imaging (DTI) have been published. This is because DTI allows to evaluate in vivo and in a non-invasive way the process of diffusion of water molecules in biological tissues. However, the simplified description of the diffusion process assumed in DTI does not permit to completely map the complex underlying cellular components and structures, which hinder and restrict the diffusion of water molecules. These limitations can be partially overcome by means of diffusion kurtosis imaging (DKI). The aim of this paper is the description of the theory of DKI, a new topic of growing interest in radiology. DKI is a higher or…
Assonanze ritmiche tra movimento grafico e segno digitale
2015
L’accostamento di più lettere costruisce nuove parole, significanti e concetti. Quando a queste lettere si associa l’idea di suono si disegna la forma degli oggetti. Schopenhauer fondò la sua teoria dei colori sulla bipartizione dell’attività della retina, paragonandola alla scala musicale, in quanto i colori erano posti in un rapporto numerico razionale tra loro. Pierre Boulez, partendo dall’opera e dalle lezioni di Paul Klee al Bauhaus, sviluppa una riflessione sulla distribuzione e sul ritmo dello spazio musicale; infatti nella serie di incisioni o di quadri come Le città, la simmetria, più che un paesaggio urbano, evoca un rigo musicale con le linee disegnate dalle note distribuite sott…
Rappresentazioni vertiginose. Tre esempi: Perec, Lequeu, Douat
2022
Nel novembre del 2009 il Museo del Louvre decise di affidare a Umberto Eco la direzione di una serie di conferenze da tenere su un argomento di sua scelta. Eco scelse il tema della ‘lista’ conferendo a quella manifestazione il nome di Vertige de la liste a cui seguì un saggio dallo stesso titolo pubblicato da Bompiani. Questa breve nota prende in prestito la stessa tematica che, per via del suo carattere altamente ete-rogeneo, è in grado di coinvolgere diversi ambiti del sapere senza minimamente accennare ad esaurirsi. L’elenco, strettamente legato alla figura retorica dell’accumulazione, può infatti costituirsi di segni, parole, suoni e di qualsiasi altra forma di rappresentazione utile a …
Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: linear kinetics (I).
2008
Modeling and simulation approaches are useful tools to assess the potential outcome of different scenarios in bioequivalence studies. The aim of this study is to propose a new and improved semi-physiological model for bioequivalence trial simulations and apply it for all BCS (Biopharmaceutic Classification System) drug classes with non-saturated first-pass hepatic metabolism. The semi-physiological model was developed in NONMEM VI to simulate bioequivalence trials. Parent drug and metabolite levels for both reference and test were simulated. Eight types of drugs (with high or low permeability and high or low solubility (class I to IV) and high or low intrinsic clearance) were considered in …
Rapid in vitro test to predict ocular tissue permeability based on biopartitioning micellar chromatography.
2003
The drug permeability prediction across the ocular tissues is important in the development of new drugs and drug delivery strategies. Physicochemical characteristics of drugs, mainly acid-base character, hydrophobicity and the molecular size determine both their transport across the eye tissue barriers and their retention in biopartitioning micellar chromatography (BMC). An in vitro model able to describe and predict the whole cornea drug permeability is proposed. The model uses the retention of drugs in BMC and molecular weight (MW) as predictive variables. The relationships between drug retention data in BMC and their bibliographic permeability values in stroma, epithelium-plus-stroma and…
Importance and methodologies of endodontic microleakage studies: A systematic review
2017
Introduction It is very important to obtain a tight seal in obturated root canal, making it necessary to conduct clinical or laboratory studies on the sealability of endodontic materials. Different methodologies have been historically used to assess microleakage of different endodontic materials. The aim of the present study was to comprehensively review different material testing methods used in microleakage studies, their interpretation and importance in endodontic literature. Material and methods A systematic search was conducted in Medline, Cochrane, and Web of Science databases. In addition, the reference lists of review articles on the topic were searched. No language restriction was …
¿Puede un factor réplica del crecimiento económico futuro (PIB) explicar los rendimientos de los activos financieros cotizados en la bolsa española?
2020
El objetivo de este trabajo es analizar si un factor con capacidad predictiva sobre el crecimiento económico futuro, captura los rendimientos de los activos cotizados en la bolsa española. A su vez, se analiza la posible interpretación racional económica de los factores de Fama y French y momentum, como variables con información sobre dicho crecimiento económico futuro. Se cuantifican estos efectos para las etapas de crisis (económica: 1993-1997 y financiera: 2008-2011) y de expansión económica (1998-2007). Los resultados subrayan la relevancia y capacidad explicativa de este factor predictivo pero se encuentra una interpretación económica débil de los factores tamaño y ratio book-to-market…
The Discursive Dance : The Employee Co-operation Negotiations as an Arena for Management-by-fear
2015
The purpose of this article is to qualitatively describe and critically explain the discursive construction of employee co-operation negotiations in Finland as an arena for management-by-fear. The article consists of a theoretical review, covering the legislative basis of co-operation negotiations and recent research on management-by-fear. The empirical study consists of media texts and company media releases in Finland in 2012–2013. The main conclusions are that there are distinctive features in the co-operation negotiations that enable and enforce the possibility of management-by-fear, and thus destructive leadership. The process, supported by law and very much against the original aim, e…
When the neighborhood educates: situated learning and collaborative artistic creation as a tool in the musical formation of the future teacher
2020
RESUMEN: Este estudio describe y analiza una acción artístico-pedagógica en el ámbito de la formación inicial de docentes y desarrollada en un barrio desfavorecido de Palma de Mallorca, España. Participaron 65 estudiantes del Grado de Maestro de Educación Primaria en la asignatura de Música y 3 músicos expertos, responsables de diseñar e implementar la acción. A través de una metodología cualitativa de tipo descriptivo-interpretativo, los resultados muestran: 1) algunas características que determinaron el diseño de la acción como son el aprendizaje situado, la colaboración, la creatividad y el compromiso con la realidad social del barrio; y 2) aspectos emergentes a partir de las valoracione…