Search results for " Ileum"

Pharmacological characterization of Uracil nucleotide-sensitive P2Y receptors in mouse ileum

2010

Since uracil nucleotide-preferring receptors, belonging to the P2Y receptor family and responding to either uridine triphosphate (UTP) or uridine diphosphate (UDP), have been proposed to be present at different cellular level in the gut, regulating various functions, we aimed to investigate whether their activation by uracil nucleotides may modulate the contractility of the intestinal muscle. Experiments were carried out in vitro, and the contractility of the longitudinal muscle from mouse ileum was recorded as changes of the isometric tension. UDP or UTP evoked a concentrationdependent, tetrodotoxin insensitive, contractile response. UDP effect was antagonized by suramin and by PPADS, P2 r…

A1 ADENOSINE RECEPTOR MODULATION OF CONTRACTILITY IN MOUSE DUODENUM LONGITUDINAL MUSCLE.

2010

Experimental evidence suggests that adenosine is involved in the regulation of gastrointestinal functions. In the present study we examined the influence of adenosine on the contractile activity of mouse duodenum longitudinal muscle. Reverse transcription-polymerase chain reaction revealed the expression of all the adenosine receptors in whole thickness duodenum, being the A2B receptors expressed only in the neuromuscular layer. Mechanical activity of longitudinally oriented duodenal segments was recorded in vitro as changes in isometric tension. Adenosine produced concentration-dependent relaxation, markedly reduced by DPCPX, A1 receptor antagonist, but unaffected by DMPX or MRS 1220, A2 a…

SUBTYPES OF MUSCARINE RECEPTORS IN THE GUINEA-PIG ILEUM

1986

2-Substituierte Histamine 3. Mitt. über Struktur-Wirkungs-Beziehungen bei Histaminanaloga

1974

Es wurden verschiedene 2-substituierte Histaminderivate aus den entsprechenden 2-substituierten Imidazol-4-carbinolen dargestellt und am isolierten Ileum des Meerschweinchens auf ihre histaminartige Wirkung untersucht. 2-Substituted Histamines Some 2-substituted derivatives of histamine were synthesized from 2-substituted imidazole-4-carbinols. The histamine- or antihistamine — like activity of the resulting compounds was tested on isolated guinea pig ileum.

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 23. Mitt. Absolute Konfiguration und histaminartige Wirkung der enantiomeren α-Chlormethylhistamin…

1981

Es wird die histaminartige Wirksamkeit der enantiomeren α-Chlormethylhistamine (+)-2a und (−)-2a sowie der Nα-Methyl-α-chlormethylhistamine (+)-2b und (−)-2b am Ileum (H1) und Atrium (H2) des Meerschweinchens beschrieben und die absolute Konfiguration der Enantiomere abgeleitet. Structure-Activity Relationships of Histamine Analogues, XXIII: Absolute Configuration and Histamine-like Activity of the Enantiomeric α-Chloromethylhistamines and Nα-Methyl-α-chloromethylhistamines The histamine-like activities of the enantiomeric α-chloromethylhistamines (+)-2a and (−)-2a and of the Nα-methyl-α-chloromethylhistamines (+)-2b and (−)-2b on the guinea pig ileum (H1) and atrium (H2) are reported. The …

Synthese und pharmakologische Wirkung von carbocyclischen Muskarinanalogen

1974

Als carbocyclische Muskarinanaloga wurden das (3-Hydroxycyclopentylmethyl)trimethyl-ammonium-jodid und dessen Acetat dargestellt und am isolierten Ileum des Meerschweinchens untersucht. Synthesis and Pharmacological Activity of Carbocyclic Analogs of Muscarine As carbocyclic analogs of muscarine (3-hydroxycyclopentylmethyl)trimethylammonium iodide and (3-acetoxycyclopentylmethyl)trimethylammonium iodide were synthesized and tested on the isolated guinea pig ileum.

Äther und Ester des 4-(2-Hydroxyaethyl)-imidazols und Ester der 4-Imidazolpropionsäure 4. Mitt. über Struktur-Wirkungs-Beziehungen bei Histaminanaloga

1974

Als potentiell histaminartig wirksame Substanzen wurden Ather und Ester des 4-(2-Hydroxyaethyl)-imidazols und Ester der 4-Imidazolpropionsaure dargestellt und am isolierten Ileum des Meerschweinchens und anderen Testobjekten untersucht. Ethers and Esters of 4-(2-Hydroxyethyl)-imidazole and Esters of 4-Imidazolepropionic Acid As substances with possible histamine-like activity, ethers and esters of 4-(hydroxyethyl)-imidazole and esters of 4-imidazolepropionic acid are prepared and tested on isolated guinea pig ileum and other objects.

D1 receptors play a major role in the dopamine modulation of mouse ileum contractility

2010

Since the role of dopamine in the bowel motility is far from being clear, our aim was to analyse pharmacologically the effects of dopamine on mouse ileum contractility. Contractile activity of mouse ileum was examined in vitro as changes in isometric tension. Dopamine caused a concentration-dependent reduction of the spontaneous contraction amplitude of ileal muscle up to their complete disappearance. SCH-23390, D1 receptor antagonist, which per se increased basal tone and amplitude of spontaneous contractions, antagonized the responses to dopamine, whilst sulpiride or domperidone, D2 receptor antagonists, were without effects. The application of both D1 and D2 antagonists had additive effe…

Glucagon-Like Peptide-1 Modulates Neurally-Evoked Mucosal Chloride Secretion in the Guinea Pig Ileum In Vitro

2011

Vitamin B12 Deficiency in Children after Continent Urinary Diversion by Mainz Pouch Technique

2010

Purpose MAINZ pouch I urinary diversion provides a high-capacity, low-pressure reservoir. The use of terminal ileum can cause a decrease of vitamin B12 levels. Symptoms caused by vitamin B12 deficiency are rare, but some are irreversible, therefore annual check-ups are recommended. In this study the vitamin B12 levels in the above patients were analyzed in retrospect. Material and Methods The ileocecal segment was used for urinary tract reconstruction in > 80 children ≤17 years of age. B12 levels were determined at various time points within up to 21 years after surgery in 63 patients (8 with ileocecal bladder substitution, 55 continent cutaneous diversion). B12 values below 200pg/ml were c…