Search results for " Imaging"

Radiolabeling of Nanoparticles and Polymers for PET Imaging

2014

Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screeni…

Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT

2021

Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…

Prevalencia y factores de desgaste profesional en radiólogos durante la pandemia COVID-19

2022

Antecedentes: La epidemia por coronavirus 2019 (COVID-19) se ha extendido por todo el mundo desde principios de 2020, sometiendo a los profesionales sanitarios a una sobrecarga laboral ya un mayor nivel de estrés físico y emocional. Objetivos: El objetivo de este estudio es determinar la prevalencia de desgaste profesional y sus posibles factores asociados en los radiólogos españoles durante la COVID-19, y su comparación con la situación previa a la pandemia. Métodos: Estudio observacional realizado entre los meses de abril y agosto de 2020 (durante la pandemia) mediante una encuesta en línea. Se obtuvieron un total de 150 respuestas. Se recopiló y comparó la información demográfica y labor…

Hyperspectral Imaging of Macroinvertebrates : a Pilot Study for Detecting Metal Contamination in Aquatic Ecosystems

2018

The applicability of spectral analysis in detection of freshwater metal contamination was assessed by developing and testing a novel hyperspectral imaging (HSI) application for aquatic insect larvae (Trichoptera: Hydropsychidae). Larvae were first exposed to four different cadmium (Cd) concentrations: 0, 1, 10, and 100 μg L−1 for 96 h. Individual larvae were then preserved in ethanol, inspected with microscopy for the number of anomalies in larval gills, and imaged by hyperspectral camera operating with wavebands between 500 and 850 nm. Three additional larvae from each exposure were analyzed for tissue Cd concentration. Although the larval tissue Cd concentrations correlated positively wit…

Structured reporting of rectal cancer staging and restaging: A consensus proposal

2021

Background: Structured reporting (SR) in oncologic imaging is becoming necessary and has recently been recognized by major scientific societies. The aim of this study was to build MRI-based structured reports for rectal cancer (RC) staging and restaging in order to provide clinicians all critical tumor information. Materials and Methods: A panel of radiologist experts in abdominal imaging, called the members of the Italian Society of Medical and Interventional Radiology, was established. The modified Delphi process was used to build the SR and to assess the level of agreement in all sections. The Cronbach’s alpha (Cα) correlation coefficient was used to assess the internal consistency of ea…

Baveno VII – Renewing consensus in portal hypertension

2022

To expand on the work of previous meetings, a virtual Baveno VII workshop was organised for October 2021. Among patients with compensated cirrhosis or compensated advanced chronic liver disease (cACLD – defined at the Baveno VI conference), the presence or absence of clinically significant portal hypertension (CSPH) is associated with differing outcomes, including risk of death, and different diagnostic and therapeutic needs. Accordingly, the Baveno VII workshop was entitled “Personalized Care for Portal Hypertension”. The main fields of discussion were the relevance and indications for measuring the hepatic venous pressure gradient as a gold standard, the use of non-invasive tools for the …

The McKenzie method in assessing, classifying and treating non-specific low back pain in adults with special reference to the centralization phenomen…

2010

HYPERBLEND: SIMULATING SPECTRAL REFLECTANCE AND TRANSMITTANCE OF LEAF TISSUE WITH BLENDER

2022

Abstract. Remotely sensing vegetation condition and health hazards requires modeling the connection of plants’ biophysical and biochemical parameters to their spectral response. Even though many models exist already, the field suffers from lack of access to program code. In this study, we will assess the feasibility of open-source 3D-modeling and rendering software Blender in simulating hyperspectral reflectance and transmittance of leaf tissue to serve as a base for a more advanced large-scale simulator. This is the first phase of a larger HyperBlend project, which will provide a fully open-source, canopy scale leaf optical properties model for simulating remotely sensed hyperspectral imag…

Choroidal thickness in glaucoma patients and glaucoma suspects measured by spectral domain coherence optical tomography

2012

Purpose: The aim of our study was to evaluate and compare retro-foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open-angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle-closure glaucoma (PACG) by spectral domain optical coherence tomography (SD-OCT).Methods: Sixty-five healthy eyes, 30 eyes with intraocular hypertension, 90 eyes with POAG, 30 eyes with NTG and 20 eyes with PACG were included in this cross-sectional study. RFCT, foveolar retinal thickness and average retinal nerve fiber layer thickness (RNFL) were measured by SD-OCT (Spectralis HRA-OCT, Heidelberg Engineer…

Contributions à l’imagerie polarimétrique et à ses applications en vision pour la robotique

2019

Ce mémoire présente le bilan de l'ensemble de mes travaux de recherche effectués de septembre 2006 à juin 2019 au sein de l'équipe Creusotine du laboratoire Le2i devenue équipe Vibot ERL CNRS 6000 depuis janvier 2018. Les principales activités de recherche que j'ai menées au cours de ces 10 dernières années autour de l'imagerie polarimétrique, de la vision omnidirectionnelle et de leurs applications en vision pour la robotique seront particulièrement détaillées dans ce document. Elles seront présentées selon deux grandes parties : la première concernera plutôt l'aspect mise en œuvre et calibrage des caméras et la seconde se concentrera sur les applications potentielles en vision pour la rob…