Search results for " In C"

Implementation Aspects of 3D Lattice-BGK: Boundaries, Accuracy, and a New Fast Relaxation Method

1999

In many realistic fluid-dynamical simulations the specification of the boundary conditions, the error sources, and the number of time steps to reach a steady state are important practical considerations. In this paper we study these issues in the case of the lattice-BGK model. The objective is to present a comprehensive overview of some pitfalls and shortcomings of the lattice-BGK method and to introduce some new ideas useful in practical simulations. We begin with an evaluation of the widely used bounce-back boundary condition in staircase geometries by simulating flow in an inclined tube. It is shown that the bounce-back scheme is first-order accurate in space when the location of the non…

Donne e musica nelle istituzioni religiose di Palermo fra Rinascimento e Barocco

2015

La centralità della donna nella cultura siciliana dei secoli passati è ormai da tempo riconosciuta. Tale centralità emerge particolarmente per le figure femminili confinate all’interno delle mura dei monasteri. Di fatto, nonostante venissero “private” della loro voce, le donne palermitane se ne riappropriavano attraverso la musica, intesa sia come esercizio pratico sia come promozione e committenza di importanti iniziative musicali, non solo all’interno delle comunità femminili, ma pure in relazione alle più prestigiose istituzioni maschili. Ben lungi dell'esaurire l’argomento, il contributo intende fornire un quadro generale della situazione nelle istituzioni ecclesiastiche di Palermo, pre…

SM identification of approximating models forH∞ robust control

1999

Set Membership (SM) W, identification of mixed parametric and nonparametric models is investigated, aimed to estimate a low order approximating model and an identification error, giving a measure of the unmodeled dynamics in a form well suited for H, control methodologies. In particular, the problem of estimating the parameters of the parametric part and the H, bound on the modeling error is solved using frequency domain data, supposing lbo bounded measurement errors and exponentially stable unmodeled dynamics. The effectiveness of the proposed procedure is tested on some numerical examples, showing the advantages of the proposed methods over the existing nonparametric H, identification app…

Verso la nuova olivicoltura: modelli d'impianto, cultivar e tecniche colturali

In the literature: October 2019

2019

Gastrointestinal cancers are a subset of molecularly heterogeneous diseases. In the era of personalised medicine, major efforts are being made towards stratifying patients according to molecular profiling. However, although most treatments are currently based on targeted therapy in relation to specific genomic alterations, acquired resistance emerges during anticancer therapies and subsequently treatment failure occurs. Intratumour heterogeneity plays a significant role in the acquisition of resistance by clonal evolution of tumour cell populations under therapeutic pressure. Despite a single tumour biopsy represents the standard for cancer research and drives our therapeutic decisions, lim…

Two independent epigenetic biomarkers predict survival in neuroblastoma.

2015

Background Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical need for additional biomarkers to improve risk stratification, treatment management, and survival rates in children with aggressive NB. Results Using gene promoter methylation analysis in 48 neuroblastoma tumors with microarray technology, we found a strong association between survival and gene promoter hypermethylation (P = 0.036). Hypermethylation of 70 genes significantly …

Assessment of Clonal Evolution in 42 AML with NPM1 Mutations by Molecular Characterization of Paired Diagnosis and Relapse Samples

2011

Abstract Abstract 237 Mutations in the nucleophosmin 1 (NPM1) gene represent one of the most frequent gene mutations in acute myeloid leukemia (AML), in particular in cytogenetically normal (CN)-AML. NPM1 mutations (NPM1mut) are considered as an early genetic event in the pathogenesis of AML. To address the role of clonal evolution from diagnosis to relapse in NPM1mut AML, we applied high-resolution genome-wide single nucleotide polymorphism (SNP) array analysis using the Affymetrix 6.0 platform to detect copy number alterations (CNAs) and uniparental disomies (UPDs) in paired samples from 42 patients. In addition, we determined NPM1 and FLT3 [internal tandem duplication (ITD) and tyrosine …

A Survey on Ontology Evaluation Methods

2015

International audience; Ontologies nowadays have become widely used for knowledge representation, and are considered as foundation for Semantic Web. However with their wide spread usage, a question of their evaluation increased even more. This paper addresses the issue of finding an efficient ontology evaluation method by presenting the existing ontology evaluation techniques, while discussing their advantages and drawbacks. The presented ontology evaluation techniques can be grouped into four categories: gold standard-based, corpus-based, task-based and criteria based approaches.

Modeling Changes for SHOIN(D) Ontologies: An Exhaustive Structural Model

2013

Ontology development starts with a rigorous ontological analysis that provides a conceptualization of the domain to model agreed by the community. An ontology, specified in a formal language, approximates the intended models of this conceptualization. It needs then to be revised and refined until an ontological commitment is found. Also ulterior updates, responding to changes in the domain and/or the conceptualization, are expected to occur throughout the ontology life cycle. To handle a consistent application of changes, a couple of ontology evolution methodologies have been proposed. Maintaining the structural consistency is one of the ontology evolution criteria. It implies modeling chan…

PREVALENCE OF METABOLIC SYNDROME IN CHRONIC ISCHEMIC HEART DISEASE

2006

PREVALENCE OF METABOLIC SYNDROME IN CHRONIC ISCHEMIC HEART DISEASE