Search results for " Infiltration"

Impairment of TGF-β signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice

2002

In autoimmune hepatitis, strong TGF-beta1 expression is found in the inflamed liver. TGF-beta overexpression may be part of a regulatory immune response attempting to suppress autoreactive T cells. To test this hypothesis, we determined whether impairment of TGF-beta signaling in T cells leads to increased susceptibility to experimental autoimmune hepatitis (EAH). Transgenic mice of strain FVB/N were generated expressing a dominant-negative TGF-beta type II receptor in T cells under the control of the human CD2 promoter/locus control region. On induction of EAH, transgenic mice showed markedly increased portal and periportal leukocytic infiltrations with hepatocellular necroses compared wit…

Hydrodynamic response of a loam soil after wetting with different methods

2023

Different points in a field can be wetted with different natural or artificial rainfall amounts and intensities. Therefore, a non-uniform soil wetting could occur during short-term monitoring of soil hydrodynamic parameters and its global effect on soil characterization is not easily predictable. For an initially dry loam soil, a sequence of three beerkan infiltration runs was performed at fixed sampling points in a period of two weeks. Immediately after the first beerkan run, the soil was perturbed by adding an additional water volume differing with the sampling point by the amount of water (0, 100 or 227 mm) and the application methodology (rainfall simulation, another beerkan run). As co…

Testing infiltration run effects on the estimated water transmission properties of a sandy-loam soil

2016

Abstract Testing factors influencing determination of soil water transmission properties by an infiltrometer method helps better interpretation of the collected data and allows the development of appropriate sampling strategies for the intended use of the data. These factors include the soil water content at the start of the experiment, the height from which water is poured onto the soil surface, and the duration of the infiltration run. A sandy-loam soil was sampled with the BEST (Beerkan Estimation of Soil Transfer parameters) procedure of soil hydraulic characterization and two heights of pouring of water (0.03 and 1.5 m) under three different initial soil water content, θ i (0.12 ≤ θ i …

One-Dimensional Transient Analysis of Rainfall Infiltration in Unsaturated Volcanic Ash

2015

The paper presents a one-dimensional hydro-mechanical analysis of rainfall infiltration in a loose volcanic ash and the utilisation of a factor of safety for the implementation of an early-warning system. Three different rainy seasons with different rainfall patterns were analysed . The analysis aims to understand the influence of the antecedent rainfall on the wetting front, the pore-water pressures and the factor of safety. The analysis was carried out in the context of a Master project of the first author at the Laboratory for Soil Mechanics of EPFL.

Variable power-law scaling of hillslope Hortonian rainfall–runoff processes

2019

Hydrological studies focused on Hortonian rainfall–run-off scaling have found that the run-off depth generally declines with the plot length in power-law scaling. Both the power-law proportional coefficient and the scaling exponent show great variability for specific conditions, but why and how they vary remain unclear. In the present study, the scaling of hillslope Hortonian rainfall–run-off processes is investigated for different rainfall, soil infiltration, and hillslope surface characteristics using the physically based cell-based rainfall-infiltration-run-off model. The results show that both temporally intermittent and steady rainfalls can result in prominent power-law scaling at the …

INVESTIGATIONS ON INFILTRATION METHODS FOR AN IMPROVED SOIL HYDRAULIC CHARACTERIZATION

2020

Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

2015

Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infar…

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

2015

International audience; Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC domain containing 13) gene (also called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse. This mutation (Zdhhc13luc) was identified as a nonsense base substitution, which results in a premature stop codon that generates a truncated form of the ZDHHC13 protein, representing a potential loss-of-function allele. Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness. Increased keratinocyte proliferation and accel…

Mast Cell Deficiency Protects Susceptible BALB/c Mice from Progressive Murine Cutaneous Leishmaniasis.

2020

Leukemia Cutis: A Report of 17 Cases and a Review of the Literature

2016

Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Leukemia cutis refers to the infiltration of the skin with neoplastic leukocytes and its early diagnosis has important prognostic implications. We report on 17 cases of leukemia cutis seen in our department between 1994 and 2014 and describe the characteristics of the patients (age, sex, medical history), the morphology of the lesions, and associations with systemic disease. Most of the patients were male and the most common associated malignancy was acute myeloid leukemia. The most frequent dermatologic manifestations were nodules or erythem…