Search results for " Informatica"
showing 10 items of 978 documents
Integrative bioinformatics and omics data source interoperability in the next-generation sequencing era-Editorial.
2021
With the advent of high-throughput and next-generation sequencing (NGS) technologies [1], huge amounts of ‘omics’ data (i.e. data from genomics, proteomics, pharmacogenomics, metagenomics, etc.) are continuously produced. Combining and integrating diverse omics data types is important in order to investigate the molecular machinery of complex diseases, with the hope for better disease prevention and treatment [2]. Experimental data repositories of omics data are publicly available, with the main aim of fostering the cooperation among research groups and laboratories all over the world. However, despite their openness, the effective integrated use of available public sources is hampered by t…
VAMPIRE: Vessel assessment and measurement platform for images of the REtina
2011
We present VAMPIRE, a software application for efficient, semi-automatic quantification of retinal vessel properties with large collections of fundus camera images. VAMPIRE is also an international collaborative project of four image processing groups and five clinical centres. The system provides automatic detection of retinal landmarks (optic disc, vasculature), and quantifies key parameters used frequently in investigative studies: vessel width, vessel branching coefficients, and tortuosity. The ultimate vision is to make VAMPIRE available as a public tool, to support quantification and analysis of large collections of fundus camera images.
Automated Detection of Optic Disc Location in Retinal Images
2008
This contribution presents an automated method to locate the optic disc in color fundus images. The method uses texture descriptors and a regression based method in order to determine the best circle that fits the optic disc. The best circle is chosen from a set of circles determined with an innovative method, not using the Hough transform as past approaches. An evaluation of the proposed method has been done using a database of 40 images. On this data set, our method achieved 95% success rate for the localization of the optic disc and 70% success rate for the identification of the optic disc contour (as a circle).
Clustering local tourism systems by threshold acceptance
2015
Despite the importance of tourism as a leading industry in the development of a country’s economy, there is a lack of criteria and methodologies for the detection, promotion and governance of local tourism systems. We propose a quantitative approach for the detection of local tourism systems that are optimal with respect to geographical, economic, and demographical criteria. To this end, we formulate the issue as an optimization problem, and we solve it by means of Threshold Acceptance, a meta-heuristic algorithm which does not require us to predefine the number of clusters and also does not require all geographic areas to belong to a cluster.
Experiments on Concurrent Artificial Environment
2001
We show how the simulation of concurrent system is of interest for both behavioral studies and strategies of learning applied on prey-predator problems. In our case learning studies into unknown environment have been applied to mobile units by using genetic algorithms (GA). A set of trajectories, generated by GA, are able to build a description of the external scene driving a predators to a prey. Here, an example of prey-predator strategy,based on field of forces, is proposed. The evolution of the corespondent system can be formalized as an optimization problem and, for that purpose, GA can be use to give the right solution at this problem. This approach could be applied to the autonomous r…
Agents Displacement in Arbitrary Geometrical Spaces: An Evolutionary Computation based Approach
2015
In many different social contexts, communication allows a collective intelligence to emerge. However, a correct way of exchanging information usually requires determined topological configurations of the agents involved in the process. Such a configuration should take into account several parameters, e.g. agents positioning, their proximity and time efficiency of communication. Our aim is to present an algorithm, based on evolutionary programming, which optimizes agents placement on arbitrarily shaped areas. In order to show its ability to deal with arbitrary bi-dimensional topologies, this algorithm has been tested on a set of differently shaped areas that present concavities, convexities …
Trusted dynamic storage for dunbar-based P2P online social networks
2014
Online Social Networks (OSNs) are becoming more and more popular in today's Internet. Distributed Online Social Networks (DOSNs), are OSNs which do not exploit a central server for storing users' data and enable users to have more control on their profile content, ensuring a higher level of privacy. The main challenge of DOSNs comes from guaranteeing availability of the data when the data owner is offline. In this paper we propose a new P2P dynamic approach to the problem of data persistence in DOSNs. By following Dunbar's approach, our system stores the data of a user only on a restricted number of friends which have regular contacts with him/her. Users in this set are chosen by considerin…
Epidemic diffusion of social updates in Dunbar-based DOSN
2014
Distributed Online Social Networks (DOSNs) do not rely on a central repository for storing social data so that the users can keep control of their private data and do not depend on the social network provider. The ego network, i.e. the network made up of an individual, the ego, along with all the social ties she has with other people, the alters, may be exploited to define distributed social overlays and dissemination protocols. In this paper we propose a new epidemic protocol able to spread social updates in Dunbar-based DOSN overlays where the links between nodes are defined by considering the social interactions between users. Our approach is based on the notion of Weighted Ego Betweenne…
Analyzing and organizing the sonic space of vocal imitations
2015
The sonic space that can be spanned with the voice is vast and complex and, therefore, it is difficult to organize and explore. In order to devise tools that facilitate sound design by vocal sketching we attempt at organizing a database of short excerpts of vocal imitations. By clustering the sound samples on a space whose dimensionality has been reduced to the two principal components, it is experimentally checked how meaningful the resulting clusters are for humans. Eventually, a representative of each cluster, chosen to be close to its centroid, may serve as a landmark in the exploration of the sound space, and vocal imitations may serve as proxies for synthetic sounds.
A visual framework to create photorealistic retinal vessels for diagnosis purposes
2020
The methods developed in recent years for synthesising an ocular fundus can be been divided into two main categories. The first category of methods involves the development of an anatomical model of the eye, where artificial images are generated using appropriate parameters for modelling the vascular networks and fundus. The second type of method has been made possible by the development of deep learning techniques and improvements in the performance of hardware (especially graphics cards equipped with a large number of cores). The methodology proposed here to produce high-resolution synthetic fundus images is intended to be an alternative to the increasingly widespread use of generative ad…