Search results for " Insulin resistance"

showing 10 items of 83 documents

Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin.

2005

Objective: Metabolic syndrome (MBS) is a significant health care problem in postmenopausal women and is driven largely by obesity. We wished to assess the prevalence of insulin resistance (IR), diagnosed using practical methods, and whether several adipocyte factors (adiponectin, leptin, resistin) or the gastric peptide ghrelin, associated with cardiovascular risk, might be abnormal and may relate to IR. Study design: We evaluated 37 obese postmenopausal women with MBS and 34 matched obese premenopausal controls, as well as 14 non-obese premenopausal controls. We measured fasting glucose and insulin, performed 75g 2 hr oral glucose tolerance and intravenous insulin tolerance tests to assess…

AdultLeptinmedicine.medical_specialtymedicine.medical_treatmentPeptide HormonesBody Mass Indexchemistry.chemical_compoundInsulin resistanceInternal medicineAdipocytemedicinePostmenopausal Insulin resistance Metabolic syndrome Adiponectin Leptin Resistin GhrelinHumansResistinObesityMetabolic SyndromeAdiponectinbusiness.industryLeptinInsulinnutritional and metabolic diseasesObstetrics and GynecologyMiddle Agedmedicine.diseaseGhrelinPostmenopauseEndocrinologychemistryPremenopauseCase-Control StudiesResistinGhrelinFemaleAdiponectinMetabolic syndromeInsulin Resistancebusinesshormones hormone substitutes and hormone antagonistsAmerican journal of obstetrics and gynecology
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Oxidative status in nondiabetic middle-aged subjects with metabolic syndrome: preliminary data.

2013

AdultMaleEndocrinology Diabetes and MetabolismMedicine (miscellaneous)PhysiologyEnzyme-Linked Immunosorbent AssayOxidative phosphorylationNitric OxideAntioxidantsProtein CarbonylationText miningMedicineHumansTriglyceridesMetabolic SyndromeNutrition and Dieteticsbusiness.industryCholesterol HDLMiddle Agedmedicine.diseaseOxidative StressLinear ModelsFemaleLipid PeroxidationMetabolic syndromeCardiology and Cardiovascular MedicinebusinessLipid peroxidation total antioxidant status insulin resistanceNutrition, metabolism, and cardiovascular diseases : NMCD
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Diabetes mellitus prevalence and control in sleep-disordered breathing: The European Sleep Apnea Cohort (ESADA) study

2014

BACKGROUND: OSA is associated with an increased risk of cardiovascular morbidity. A driver of this is metabolic dysfunction and in particular type 2 diabetes mellitus (T2DM). Prior studies identifying a link between OSA and T2DM have excluded subjects with undiagnosed T2DM, and there is a lack of population-level data on the interaction between OSA and glycemic control among patients with diabetes. We assessed the relationship between OSA severity and T2DM prevalence and control in a large multinational population.METHODS: We performed a cross-sectional analysis of 6,616 participants in the European Sleep Apnea Cohort (ESADA) study, using multivariate regression analysis to assess T2DM prev…

AdultMalePulmonary and Respiratory MedicineAdolescentPolysomnographySettore MED/10 - Malattie Dell'Apparato RespiratorioCritical Care and Intensive Care MedicineSeverity of Illness IndexRegression AnalysiCohort Studiesintermittent hypoxia insulin resistance HbA1CYoung AdultSleep Apnea SyndromesSleep Apnea SyndromeRisk FactorsPrevalenceHumansProspective StudiesIsraelAgedGlycated HemoglobinAged 80 and overCross-Sectional StudieHemoglobin A GlycosylatedRisk FactorMiddle AgedEuropeProspective StudieCross-Sectional StudiesDiabetes Mellitus Type 2Regression AnalysisFemaleCohort StudieCardiology and Cardiovascular MedicineHuman
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Is diabetes in Cushing's syndrome only a consequence of hypercortisolism?

2014

ObjectiveDiabetes mellitus (DM) is one of the most frequent complications of Cushing's syndrome (CS). The aim of this study was to define the changes in insulin sensitivity and/or secretion in relation to glucose tolerance categories in newly diagnosed CS patients.DesignCross-sectional study on 140 patients with CS.MethodsA total of 113 women (80 with pituitary disease and 33 with adrenal disease, aged 41.7±15.7 years) and 27 men (19 with pituitary disease and eight with adrenal disease, aged 38.1±20.01 years) at diagnosis were divided according to glucose tolerance into normal glucose tolerance (CS/NGT), impaired fasting glucose and/or impaired glucose tolerance (CS/prediabetes), and diabe…

AdultMalemedicine.medical_specialtyHydrocortisoneEndocrinology Diabetes and Metabolismmedicine.medical_treatmentCushing's syndromeSettore MED/13 - EndocrinologiaPrediabetic StateImpaired glucose toleranceEndocrinologyInsulin resistanceInternal medicineDiabetes mellitusInsulin SecretionGlucose IntoleranceDiabetes MellitusmedicineHumansInsulinPrediabetesCushing SyndromeRetrospective StudiesCushing DiabetesGlucose tolerance testhypercortisolismmedicine.diagnostic_testbusiness.industryInsulinGeneral MedicineGlucose Tolerance TestMiddle Agedmedicine.diseaseImpaired fasting glucoseDiabetes and MetabolismCross-Sectional StudiesPhenotypeEndocrinologyDiabetes Mellitus Type 2diabeteFemaleInsulin ResistanceMetabolic syndromebusinessAdult; Cross-Sectional Studies; Cushing Syndrome; Diabetes Mellitus Type 2; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Insulin Resistance; Male; Middle Aged; Phenotype; Prediabetic State; Retrospective Studies; Endocrinology Diabetes and Metabolism; EndocrinologyType 2European Journal of Endocrinology
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Insulin-resistance HCV infection-related affects vascular stiffness in normotensives

2015

BACKGROUND AND AIMS. Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. METHODS. We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV(+)), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insu…

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina Internamedicine.medical_treatmentArterial stiffness; Chronic hepatitis C virus infection; Insulin resistanceInsulin resistance; chronic hepatitis C virus infection; arterial stiffnessBlood PressurePulse Wave AnalysisBody Mass Indexchemistry.chemical_compoundVascular StiffnessInsulin resistanceRisk FactorsHyperinsulinismInternal medicinemedicineHyperinsulinemiaHumansInsulinPulse wave velocityCreatinineTriglyceridebusiness.industryInsulinInsulin resistanceHepatitis CHepatitis C ChronicMiddle Agedmedicine.diseaseArterial stiffnearterial stiffnessEndocrinologychemistryCase-Control StudiesHypertensionLinear ModelsArterial stiffnessFemaleCardiology and Cardiovascular MedicinebusinessChronic hepatitis C virus infection
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Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes

2009

Abstract OBJECTIVE: To evaluate the clinical and endocrine differences between main polycystic ovary syndrome (PCOS) phenotypes. DESIGN: To evaluate clinical and hormone parameters in a large group of consecutive women with PCOS diagnosed according Rotterdam criteria and divided according their phenotype. SETTING: University department of medicine. PATIENT(S): Three hundred eighty-two consecutive women with PCOS and 85 ovulatory controls. INTERVENTION(S): Evaluation of clinical and hormone parameters. MAIN OUTCOME MEASURE(S): Blood levels of gonadotropins, testosterone, sex-hormone-binding globulin, dehydroepiandrosterone sulfate, 17α-hydroxyprogesterone, progesterone, glucose, and insulin,…

AdultPCOS Lipids Insulin resistance Fertility Androgens Obesitymedicine.medical_specialtySettore MED/09 - Medicina Internaendocrine system diseasesEndocrine SystemSettore MED/13 - EndocrinologiaAnovulationYoung Adultchemistry.chemical_compoundDehydroepiandrosterone sulfateSex Hormone-Binding GlobulinInternal medicinePrevalencemedicineHumansTestosteroneRetrospective StudiesDehydroepiandrosterone SulfateFree androgen indexbusiness.industryHyperandrogenismObstetrics and GynecologyLuteinizing Hormonemedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaPolycystic ovaryfemale genital diseases and pregnancy complicationsPhenotypeEndocrinologyReproductive MedicinechemistryCase-Control StudiesAndrogensFemaleFollicle Stimulating HormoneHyperandrogenismLuteinizing hormonebusinessPolycystic Ovary SyndromeHormoneFertility and Sterility
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PCOS: metabolic impact and long-term management.

2012

Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women, affecting up to 10% of those in reproductive age. Furthermore, PCOS presents a lifetime risk of type II diabetes, cardiovascular diseases and endometrial cancer. Women with PCOS have increased cardiovascular risk; however, the risk is not the same in all patients and it is necessary to assess an individual risk profile. There is a discrepancy between increased cardiovascular risk at young age and postmenopausal number of cardiovascular events, probablu depending on changes in androgen ovarian function after the forties. However, changes with age of metabolic profile in women with PCOS have not been studied yet an…

AdultSettore MED/09 - Medicina InternaAdolescentComorbiditySettore MED/11 - Malattie Dell'Apparato CardiovascolareMetforminSettore MED/13 - EndocrinologiaDiabetes Mellitus Type 2Cardiovascular DiseasesRisk FactorsObesity AbdominalPCOS Metabolic Syndrome Cardiovascular risk aging insulin resistance hyperandrogenismHypertensionHumansFemaleHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceChildAntihypertensive AgentsDyslipidemiasPolycystic Ovary SyndromeMinerva ginecologica
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A 20-year follow-up of young women with polycystic ovary syndrome.

2012

OBJECTIVE: To determine whether hormonal, metabolic, and anthropomorphic parameters change over 20 years in women with polycystic ovary syndrome (PCOS). METHODS: One hundred ninety-three women with PCOS, aged 20–25 years, were diagnosed according to Rotterdam criteria, divided into four phenotypes (A–D), and followed at 5-year intervals for 20 years. Androgens, gonadotropins, insulin, glucose, body mass index, waist circumference, and ovarian volume were measured. RESULTS: At diagnosis, 57% had classic features (phenotype A), 9% had classic features without ovarian findings (phenotype B), 26% had the ovulatory phenotype (C), and 7% were nonhyperandrogenic (D). After 10 years, androgens decr…

Adultendocrine system diseasesPhysiologySettore MED/13 - EndocrinologiaBody Mass IndexYoung AdultInsulin resistanceOvarian functionmedicineHumansInsulinTestosteroneYoung adultInsulin bloodbusiness.industryOvaryFollow up studiesObstetrics and GynecologyDehydroepiandrosteroneOrgan SizeLuteinizing HormoneMiddle Agedmedicine.diseasePolycystic ovaryfemale genital diseases and pregnancy complicationsPolycystic Ovary Syndrome Ovarian function Ovarian aging Androgens Insulin resistance waist circumferencePhenotypeFemaleFollicle Stimulating HormoneInsulin ResistanceWaist CircumferencebusinessBody mass indexHormoneAnovulationFollow-Up StudiesPolycystic Ovary SyndromeObstetrics and gynecology
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Lower insulin sensitivity differentiates hirsute from non-hirsute Sicilian women with polycystic ovary syndrome

2006

Objective: It is well known that hyperandrogenism and insulin-resistance with or without compensatory hyperinsulinism are closely associated, but the Rotterdam Consensus has concluded that principally obese women with polycystic ovary syndrome (PCOS) should be evaluated for the metabolic syndrome. Our aim was to study insulin sensitivity in PCOS women with hirsutism regardless of obesity. Methods: Clinical characteristics, sex hormones and fasting- and after OGTT-glycemia and insulinemia, homeostatic model of insulin resistance (HOMA IR), and Matsuda index of insulin sensitivity were analyzed in 130 women with PCOS. Hirsutism has been evaluated through the Ferriman–Gallwey (FG) map scoring …

Adultmedicine.medical_specialtyHirsutismAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSettore MED/13 - EndocrinologiaDiagnosis DifferentialEndocrinologyInsulin resistanceInternal medicineHyperinsulinismmedicineHumansTestosteroneObesitySicilyhirsutismMetabolic Syndromebusiness.industryDehydroepiandrosterone SulfateInsulinHyperandrogenismAndrostenedioneGeneral Medicinemedicine.diseasePolycystic ovaryEndocrinologyPCOS INSULIN RESISTANCE HIRSUTISMFemaleMetabolic syndromeInsulin ResistancebusinessHyperandrogenismHyperinsulinismBody mass indexPolycystic Ovary Syndrome
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Association of Inflammation Markers with Impaired Insulin Sensitivity and Coagulative Activation in Obese Healthy Women

2003

Abstract Insulin resistance is associated with a low chronic inflammatory state. In this study we investigated the relationship between impaired insulin sensitivity and selected markers of inflammation and thrombin generation in obese healthy women. We examined 32 healthy obese women (body mass index ≥ 28), with normal insulin sensitivity (NIS, n = 14) or impaired insulin sensitivity (n = 18), and 10 nonobese women (body mass index < 25). Impaired insulin sensitivity patients had significantly higher levels of C-reactive protein (CRP), TGF-β1, plasminogen activator inhibitor-1 (PAI-1), activated factor VII (VIIa), and prothrombin fragment 1 + 2 (F1 + 2) compared with either control s…

Adultmedicine.medical_specialtyobesityEndocrinology Diabetes and Metabolismmedicine.medical_treatmentClinical BiochemistryPopulationInflammationFactor VIIaBiologyBiochemistryEndocrinologyInsulin resistanceTransforming Growth Factor betaInternal medicineinsulin resistancePlasminogen Activator Inhibitor 1medicineHumansProtein PrecursorseducationBlood CoagulationPancreatic hormoneeducation.field_of_studyInsulinBiochemistry (medical)ThrombinMiddle Agedmedicine.diseaseObesityPeptide FragmentsC-Reactive ProteinEndocrinologyhemostasis; inflammation; insulin resistance; obesityinflammationhemostasisFemaleProthrombinmedicine.symptomBody mass indexPlasminogen activatorBiomarkers
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