Search results for " Insulin resistance"

showing 10 items of 83 documents

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Consensus On Women'S Health Aspects Of Polycystic Ovary Syndrome (Pcos)

2012

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females with a high prevalence. The etiology of this heterogeneous condition remains obscure and its phenotype expression varies. Two, widely cited, previous ESHRE/ASRM-sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008). The present third PCOS consensus paper summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, preg…

Settore MED/09 - Medicina InternaConsensus Development Conferences as TopicmenopauseType 2 diabetesSettore MED/13 - EndocrinologiaQuality of lifecancer; cardiovascular disease; contraception; hirsutism; insulin resistance; menopause; PCOS; pregnancy; quality of life; type 2 diabetescardiovascular diseaseNeoplasmsinsulin resistancePCOShirsutismhirsutismReproductive BiologyPolycystic ovary syndrome (PCOS)RehabilitationObstetrics and GynecologyObstetrics & GynecologyMiddle AgedMenopausePhenotypecontraceptionCardiovascular DiseasesPCOS Cardiovascular risk adolescence cancer obesityFemalepregnancytype 2 diabetesPolycystic Ovary SyndromeAdultmedicine.medical_specialtyConsensusAdolescentDiabetes ComplicationsInsulin resistanceSDG 3 - Good Health and Well-beingmedicineHumanscancerMenstrual CycleAgedGynecologyPregnancybusiness.industryCancermedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaReproductive MedicineDiabetes Mellitus Type 2quality of lifeWomen's Healthbusiness
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MAGNESIUM METABOLISM IN TYPE 2 DIABETES MELLITUS

2011

Settore MED/09 - Medicina InternaMagnesium Type 2 diabetes mellitus Hypertension Ionized magnesium Insulin resistance
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Obesity: A main factor of metabolic syndrome?

2006

The metabolic syndrome (MS) is a common metabolic disorder that has been recently related to the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology has been largely attributed, in the past years, to insulin-resistance, even if several epidemiological and pathophysiological data are attractive to indicate visceral obesity as a main factor in the occurrence of the MS, promoting new definitions and re-valuation of the pathogenesis of this syndrome. In this review, we have analyzed the role of visceral obesity in the new definition of the MS such as the pathophysiological role of…

Settore MED/09 - Medicina InternaObesity Insulin resistance Metabolic syndrome Cardiovascular diseases.
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Exercise in obesity management

2011

Obesity is considered a global epidemic by the World Health Organization in both developed and developing countries. It is associated with a higher risk of cardiovascular disease, diabetes mellitus, cancer and other clinical conditions. Visceral fat is the major responsible for metabolic complications, such as insulin-resistance, and it acts as an endocrine organ producing adipokines involved in lipidic and glycaemic metabolism. TNF-α and IL-6, produced by adipose tissue, increase NADPH oxidase activity activating protein kinase C and NFκB leading to an higher oxidative stress. The obesity management includes physical activity: aerobic training improves lipid profile and insulin sensitivity…

Settore MED/09 - Medicina Internaobesity physical exercise insulin resistance
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HEPATIC STEATOSIS IS ASSOCIATED WITH SEVERE FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B

2010

Background and aim: Steatosis and insulin resistance (IR) are the major disease modifying in patients with chronic hepatitis C (CHC). Only few studies evaluated these features in patients with chronic hepatitis B (CHB). We aimed to assess the prevalence and the characteristics of steatosis and IR in CHB patients, compared to CHC subjects, and to evaluate the potential association between these features and fibrosis severity. Material and methods: 170 consecutive patients with CHB (28 HBeAg positive, 128 HBeAg negative, and 14 HBeAg negative/anti-HDV positive), and 170 sex, age and BMI matched genotype 1 CHC patients were evaluated by liver biopsy and metabolic measurements, including IR, by…

Settore MED/12 - GastroenterologiaHBV Insulin resistanceSettore MED/13 - Endocrinologia
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Hemorheology in the metabolic syndrome.

2011

blood viscosity plasma viscosity insulin resistance
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Renal function is impaired in normotensive chronic HCV patients: role of insulin resistance.

2015

Renal dysfunction is an independent predictor for cardiovascular morbidity and mortality. We investigated whether chronic hepatitis C virus (HCV) infection and the related insulin resistance/hyperinsulinemia influence renal function in comparison with a group of healthy subjects and with another group with metabolic syndrome. We enrolled 130 newly diagnosed HCV outpatients matched for age and gender with 130 patients with metabolic syndrome and 130 healthy subjects. Renal function was evaluated by calculation of glomerular filtration rate (e-GFR, mL/min/1.73 m2) using the CKD-EPI equation. The following laboratory parameters were measured: fasting plasma glucose and insulin, total, LDL- and…

cardiovascular riskMalemedicine.medical_specialtySettore MED/09 - Medicina Internamedicine.medical_treatmentRenal function030204 cardiovascular system & hematologyurologic and male genital diseasesKidney Function Testschronic C hepatitis03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInsulin resistanceChronic C hepatitis Renal function Insulin resistance Cardiovascular risk Metabolic syndromeInternal medicineInternal MedicinemedicineHyperinsulinemiaHumansMetabolic SyndromeCreatinineTriglyceridebusiness.industryInsulinrenal functionCase-control studyHepatitis C ChronicMiddle Agedmedicine.diseaseEndocrinologychemistryCase-Control Studieschronic C hepatitis; renal function; insulin resistance; cardiovascular risk; metabolic syndromeEmergency Medicine030211 gastroenterology & hepatologyFemaleMetabolic syndromeInsulin ResistancebusinessBiomarkersGlomerular Filtration RateInternal and emergency medicine
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Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes

2022

The current management of Type 2 Diabetes Mellitus (T2DM) includes incretin-based treatments able to enhance insulin secretion and peripheral insulin sensitivity as well as improve body mass, inflammation, plasma lipids, blood pressure, and cardiovascular outcomes. Dietary Free Fatty Acids (FFA) regulate metabolic and anti-inflammatory processes through their action on incretins. Selective synthetic ligands for FFA1-4 receptors have been developed as potential treatments for T2DM. To comprehensively review the available evidence for the potential role of FFA receptor agonists in the treatment of T2DM, we performed an electronic database search assessing the association between FFAs, T2DM, i…

cardiovascular riskMedicine (General)Cardiovascular risk Free fatty acidsGLP-1 Incretins Metabolism Type 2 diabetes Fatty Acids Nonesterified Humans Diabetes Mellitus Type 2 Insulin Resistanceendocrine system diseasesfree fatty acidsType 2 diabetesReviewGeneral MedicineFatty Acids NonesterifiedR5-920Diabetes Mellitus Type 2HumansInsulin ResistanceGLP-1metabolismincretinsMedicina
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Glycated albumin is correlated to insulin resistance and β-cell secretory function in subjects at risk for developing diabetes

2018

Insulin resistance and β-cell secretory function represent two main issues in the pathogenesis of type 2 diabetes mellitus (T2DM). Conflicting results have been obtained about the association between glycated albumin (GA) and body mass index (BMI), insulin resistance and β-cell function in diabetic patients. Actually, the relationship (if any) between GA and the markers of glucose homeostasis and insulin resistance in subjects at risk of developing diabetes, has not been completely elucidated yet. Two hundred and one patients undergoing to oral glucose tolerance test (OGTT) were enrolled in the study. Routine laboratory tests, including fasting insulin, were performed at enrollment. GA was …

glycated albumin insulin resistance diabetes β-cellSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicaSettore MED/13 - Endocrinologia
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