Search results for " Invasion"
showing 10 items of 162 documents
VEGFR-2, HSP90 and GRP78/BiP expression and HCC recurrence after Liver Transplantation
2018
Introduction Liver transplantation (LT) for hepatocellular carcinoma (HCC) is a satisfactory therapeutic choice in patients with “early HCC” selected according to Milan criteria. However, the risk of HCC recurrence after LT is about 7-20% at five years and molecular markers which can predict recurrence are still lacking. We investigated in HCC samples and LC surrounding tissues the significance of VEGFR-2, HSP90, and GRP78/BiP expression in patients with HCC who underwent LT in a western transplantation center and their possible role as molecular markers of recurrence. Methods 42 patients (35 M, 7 F) with early HCC who underwent LT between 2012 and 2013 were enrolled. The tumor recurrence r…
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. Compared with wild-type (WT) or C3- or C5-deficient mice, C1q-deficient (C1qa−/−) mice bearing a syngeneic B16 melanoma exhibit a slower tumour growth and prolonged survival. This effect is not attributable to differences in the tumour-infiltrating immune cells. Tumours developing in WT mice display early deposition of C1q, higher vascular density and an increase in the number of lung metastases compared with C1qa−/− mi…
Two distinct amplification events of the c-myc locus in a colorectal tumour.
2008
Southern hybridisation of genomic DNA extracted from a human primary colorectal carcinoma revealed amplification of a fragment containing the wild-type c-myc locus. Two additional rearranged DNA fragments, lying upstream of c-myc, fused to distant non-contiguous sequences from the same chromosome, with an opposite configuration (head to head vs. head to tail), were also found to be amplified. Sequences analysis suggested that these rearrangements resulted from illegitimate recombination at two distinct points within the DNA sequence just upstream of the c-myc ORF and further that these events triggered two different amplification mechanisms, only one of which, involving a strand invasion ev…
Invasions of the non-indigenous red alga Lophocladia lallemandii (Montagne) F. Schmitz off the Island of Ischia (Tyrrhenian Sea, Italy)
2021
This paper describes the distribution and spread of the non-indigenous red alga Lophocladia lallemandii (Montagne) F. Schmitz along the coast of the Island of Ischia (Tyrrhenian Sea, Italy). Lophocladia lallemandii was monitored through surveys from July 2019 to January 2020 at the Capo Sant’Angelo (Ischia), where L. lallemandii was observed, but not reported, in the years preceding the invasion of the upper rocky infralittoral shore reported here. It is noteworthy that a large portion of the study area is included within one of the two “B no-take” zones of the Marine Protected Area of the “Regno di Nettuno” (“Neptune’s Realm”). During the surveys, the alga was first observed in the middle …
Landscape in transition in the shadow of 2022 Russia’s invasion in Ukraine – notes from Hungary
2022
This research note focuses on two phenomena: the transformations in the landscape in Hungary as an effect of Russia’s invasion in Ukraine and the welcome/help centers that were established to channel mobility and provide a temporary safe space. I suggest that liminality (which serves as a main explanatory category) is characteristic of both. It is stated that in this context that the bodies of refugees are reminders of the existence of the (state) border, which gets reaffirmed by the process of welcoming and hosting and is also reflected in the visual reminders in the landscape. I also divide the management of the refugee crisis into three phases: spontaneous action, institutionalization, a…
Unpublished Mediterranean records of marine alien and cryptogenic species
2020
Este artículo contiene 18 páginas, 4 figuras.
The spreading of the invasive italian wall lizard on Vulcano, the last island inhabited by the critically endangered aeolian wall lizard
2018
[EN] The Aeolian Wall Lizard (Podarcis raffoneae) is an endemic species of the Aeolian Archipelago of Italy (Mediterranean Sea). Its distribution is limited to three islets and two relict populations on a relatively large island: Vulcano (a population on the summit of Gran Cratere volcano and another on Capo Grosso promontory). The critically endangered Aeolian Wall Lizard is threatened by the introduction of the Italian Wall Lizard (Podarcis siculus), which successfully competes and hybridizes with the endemic lizard. The invasive lizard is widespread on Vulcano, although the literature does not provide the exact distribution. Our first aim was updating the distribution of the Italian Wall…
Island incidence and mainland population density: Mammals from Mediterranean islands
2002
. The reasons why some species are resistant to extinction or are better invaders of islands than others remain unexplained. In this study, we test the hypothesis that mammals living on the mainland at higher density than predicted by the density/body mass relationship have a much greater chance to colonize a small island successfully, and/or that they are less likely to become extinct when living on small islands. For this, we used data compiled on mammals from a number of Mediterranean islands. We show a nested pattern for mammals on western Mediterranean islands, which suggests that the distribution of mammals on these islands is not the result of a random process. Using two comparative …
The importance of the concept and histological criteria of "intraepithelial squamous cell carcinoma" of the esophagus: in comparison between Western …
2017
Background There are differences in the histological diagnostic criteria for early stage gastrointestinal carcinoma between Western and Japanese pathologists. Western histological criteria of carcinoma are “presence of stromal invasion of neoplastic cells”, while Japanese criteria are “the degree of cytological and structural abnormality of neoplastic cells, regardless of stromal invasion”. The aim of the present study is to clarify and review the present status of the Western and Japanese histological criteria of early stage esophageal squamous cell carcinoma (SCC) and also to clarify their significance and accuracy. Methods Twenty-nine Polish, German, and Japanese pathologists participate…