Search results for " LAB"
showing 10 items of 2393 documents
Post-elution processing of 44Ti/44Sc generator-derived 44Sc for clinical application
2009
The (44)Ti/(44)Sc (T(1/2)(44)Ti=60a) generator provides cyclotron-independent access to positron-emitting (44)Sc (T(1/2)=3.97d) for PET imaging. This work aims to post-elution processing of initial (44)Sc generator eluates in order to reduce its volume, HCl concentration and remove the oxalate anions. The on-line adsorption of (44)Sc on cationic resin AG 50W-X8 (200-400 mesh, H(+)-form) is achieved with >98% efficacy. Subsequently, the purified (44)Sc is desorbed by using 3ml of 0.25M ammonium acetate (pH=4.0). The post-processing takes 10min. The overall yield of the post-processing reached 90%, which is referred to the (44)Sc obtained from the (44)Ti/(44)Sc generator. In addition to the c…
Radon and material radiopurity assessment for the NEXT double beta decay experiment
2015
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
ESR study of the liposome membrane physical parameters in the heating-cooling cycles.
1998
Abstract Changes of dynamic and structural parameters of egg yolk lecithin (EYL) liposome membranes in the heating-cooling cycles have been studied using the E S R spin probe method. The investigations were conducted in the range of temperatures from -18 °C to +60 °C. It has been found that in the range of temperatures -15 °C to +45 °C in both the heating and the cooling run the spectroscopic parameters changed practically along the same curve (reversible changes). However, after exceeding this range of temperatures one of the parameters (partition coefficient of the spin probe 2,2,6,6 -tetramethylpiperidine -1-oxyl; TEMPO) changed along a closed curve, showing the phenomenon of thermal h…
The N-terminal Amino Group of [Tyr8]Bradykinin Is Bound Adjacent to Analogous Amino Acids of the Human and Rat B2 Receptor
1996
To obtain data of the bradykinin B2 receptor's agonist binding site, we used a combined approach of affinity labeling and "immunoidentification" of receptor fragments generated by cyanogen bromide cleavage. Domain-specific antibodies to the various extracellular receptor domains were applied to detect receptor fragments with covalently attached [125I-Tyr8]bradykinin. As a cross-linker we used the homobifunctional reagent disuccinimidyl tartarate (DST), which reacts preferentially with primary amines. With this technique a [125I-Tyr8]bradykinin-labeled receptor fragment derived from the third extracellular domain was identified. The epsilon-amino group of lysine (Lys172) of the human B2 rece…
Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer
2021
The combination of trastuzumab plus pertuzumab plus docetaxel as a first-line therapy in patients with HER2-positive metastatic breast cancer has provided significant clinical benefits compared to trastuzumab plus docetaxel alone. However, despite the therapeutic success of existing therapies targeting HER2, tumours invariably relapse. Therefore, there is an urgent need to improve our understanding of the mechanisms governing resistance, so that specific therapeutic strategies can be developed to provide improved efficacy. It is well known that the tumour microenvironment (TME) has a significant impact on cancer behaviour. Cancer-associated fibroblasts (CAFs) are essential components of the…
Gestión de mano de obra en la empresa pública: el caso de RENFE
2008
Los cambios en las prácticas de gestión de mano de obra que se están aplicando en Renfe en las últimas décadas han conllevado una reducción drástica de la plantilla (flexibilidad en la salida), y una mayor disponibilidad laboral de los que han quedado (flexibilidad funcional). Dichos cambios guardan relación con la orientación privatizadora de la economía que impone un cuestionamiento del modelo de transporte ferroviario existente hasta fechas recientes. Asimismo, están condicionados por el hecho de ser una empresa pública (financiación presupuestaria, politización,...). El objetivo básico de las prácticas de gestión de mano de obra aplicadas en Renfe es la reducción de los costes laborales…
(Table 1) Sea surface temperature reconstruction for eastern equatorial Pacific surface sediment samples
2012
Significant uncertainties persist in the reconstruction of past sea surface temperatures in the eastern equatorial Pacific, especially regarding the amplitude of the glacial cooling and the details of the post-glacial warming. Here we present the first regional calibration of alkenone unsaturation in surface sediments versus mean annual sea surface temperatures (maSST). Based on 81 new and 48 previously published data points, it is shown that open ocean samples conform to established global regressions of Uk'37 versus maSST and that there is no systematic bias from seasonality in the production or export of alkenones, or from surface ocean nutrient concentrations or salinity. The flattening…
The Regional Effects of Public Spending on Active Labor Market Policies: Evidence from Advanced Economies
2022
This paper examines the regional effects of public spending on Active Labor Market polices (ALMPs). Using an unbalanced sample of 308 regions belonging to 29 OECD Economies for the period 1995-2011, we show that discretionary increases in public spending on active labor market policies at the national level have statistically significant short- and medium-term effect in reducing regional unemployment rate, while raising regional output. These effects tend to be larger during periods of low GDP growth, and when complemented by a larger share of cohesion fund expenditures.
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells
2015
The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3β. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in mice revealed that USP8 was essential for thymocyte maturation and upregulation of the gene encoding the cytokine receptor IL-7Rα mediated by the transcription factor Foxo1. Mice with T cell-specifi…
Dzīvnieku tiesiskās aizsardzības dažādie aspekti starptautisko un nacionālo tiesību regulējums
2016
Dzīvnieku tiesiskā aizsardzība mūsdienās ir aktuāla tēma, jo šis ir pēdējais brīdis, kad cilvēki var mainīt kaut ko lietas labā un domāt arī par apkārtējiem, tai skaitā dzīvniekiem, nevis tikai katrs par sevi. Autore šajā darbā mēģinās parādīt to, kā mūsdienās cilvēki izmanto dzīvniekus savām vajadzībām, uztverot to kā pašsaprotamu lietu un nedomājot par dzīvnieku spējām just. Uzsvars tiks likts uz tiesību aktiem, kas radušies laika gaitā, lai aizsargātu dzīvniekus un nodrošinātu viņu tiesisko aizsardzību, gan nacionālajā, gan starptautiskā līmenī.