Search results for " LAB"

showing 10 items of 2393 documents

Dietary restriction: could it be considered as speed bump on tumor progression road?

2016

Dietary restrictions, including fasting (or long-term starvation), calorie restriction (CR), and short-term starvation (STS), are considered a strong rationale that may protect against various diseases, including age-related diseases and cancer. Among dietary approaches, STS, in which food is not consumed during designed fasting periods but is typically not restricted during designated feeding periods, seems to be more suitable, because other dietary regimens involving prolonged fasting periods could worsen the health conditions of cancer patients, being they already naturally prone to weight loss. Until now, the limited amount of available data does not point to a single gene, pathway, or …

0301 basic medicinemedicine.medical_specialtySettore MED/06 - Oncologia MedicaCalorie restrictionCancer cellBiologyBioinformaticsCellular stress response03 medical and health sciencesWeight lossNeoplasmsCellular stress responseInternal medicinemedicineAnimalsHumansChemotherapyShort-term starvationSettore MED/49 - Scienze Tecniche Dietetiche ApplicateCaloric RestrictionStarvationCancerCancer cells; Cellular stress response; Chemotherapy; Diet; Fasting; Short-term starvationFastingGeneral Medicinemedicine.diseaseDietSettore MED/18 - Chirurgia Generale030104 developmental biologyEndocrinologyTumor progressionCancer cellSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioSignal transductionmedicine.symptomTumor Biology
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Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development

2020

Extracellular vesicles (EVs) are known to transport DNA, but their implications in embryonic implantation are unknown. The aim of this study was to investigate EVs production and secretion by preimplantation embryos and assess their DNA cargo. Murine oocytes and embryos were obtained from six- to eight-week-old females, cultured until E4.5 and analyzed using transmission electron microscopy to examine EVs production. EVs were isolated from E4.5-day conditioned media and quantified by nanoparticle tracking analysis, characterized by immunogold, and their DNA cargo sequenced. Multivesicular bodies were observed in murine oocytes and preimplantation embryos together with the secretion of EVs t…

0301 basic medicinemurine blastocystslcsh:QH426-470Embryonic DevelopmentexosomesArticleEmbryo Culture Techniques03 medical and health scienceschemistry.chemical_compoundMice0302 clinical medicineGeneticsmedicineAnimalsSecretionBlastocystParticle Sizeapoptotic bodiesGenetics (clinical)030219 obstetrics & reproductive medicineChemistryADP-Ribosylation FactorsTetraspanin 30BlastocoelHigh-Throughput Nucleotide SequencingEmbryoImmunogold labellingSequence Analysis DNADNAEmbryonic stem cellMicrovesiclesCell biologylcsh:Genetics030104 developmental biologymedicine.anatomical_structureBlastocystADP-Ribosylation Factor 6Culture Media Conditionedembryonic structuresOocytespreimplantation embryosFemaleextracellular vesiclesmicrovesiclesDNAGenes
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Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still's disease. Analysis of…

2020

ObjectiveTo assess the predictive role of ferritin and C-reactive protein (CRP) on occurrence of macrophage activation syndrome (MAS) and mortality in patients with adult onset Still's disease (AOSD), a rare and severe disease, included in the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort.MethodsThe predictive role, at the time of diagnosis, of serum levels of ferritin and CRP on occurrence of MAS and mortality, was evaluated by logistic regression analyses and receiver-operating characteristic (ROC) curves were built to identify patients at high risk of MAS and mortality, respectively.ResultsIn assessed 147 patients with AOSD, levels of ferri…

0301 basic medicinemyalgiaAdult-OnsetMalePredictive Value of TestPathology and Laboratory MedicineLogistic regressionBiochemistryGastroenterologyCohort StudiesMathematical and Statistical Techniques0302 clinical medicineMedicine and Health SciencesMultidisciplinarybiologyMacrophage Activation SyndromeStatisticsQRMiddle AgedC-Reactive ProteinsC-Reactive ProteinPredictive value of testsPhysical SciencesCohortRegression AnalysisMedicineFemalemedicine.symptomStill's Disease Adult-OnsetResearch ArticleCohort studyHumanAdultmedicine.medical_specialtyPatientsLogistic ModelInflammatory DiseasesSciencePainStill's Disease Adult-Onset.Research and Analysis Methods03 medical and health sciencesAdult; Biomarkers; C-Reactive Protein; Cohort Studies; Female; Ferritins; Humans; Logistic Models; Macrophage Activation Syndrome; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Still's Disease Adult-OnsetSigns and SymptomsDiagnostic MedicinePredictive Value of TestsInternal medicinemedicineHumansStatistical Methods030203 arthritis & rheumatologyFerritinbusiness.industryC-reactive proteinBiology and Life SciencesProteinsProtein ComplexesMyalgiaBiomarkermedicine.diseaseStill's DiseaseHealth CareFerritin030104 developmental biologyLogistic ModelsROC CurveMacrophage activation syndromeMultivariate AnalysisFerritinsbiology.proteinCohort StudiebusinessMathematicsBiomarkers
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Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment

2020

Abstract The ongoing outbreak of the novel coronavirus (SARS‐CoV‐2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where humans circulate and spread the virus such as airports, trains, boats, and any public aggregation places. The success of a reliable and sensitive asymptomatic diagnosis relies on the identification and measurement of informative biomarkers from human host and virus in a rapid, sensitive, …

0301 basic medicineportableSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralImmunologycoronavirusBiologymedicine.disease_causeSensitivity and SpecificityDisease OutbreaksWorkflowBetacoronavirus03 medical and health sciencesCOVID-19 Testing0302 clinical medicinePandemicmedicineAnimalsHumansMass ScreeninginstrumentImmunology and AllergyBiomarker discoveryAsymptomatic InfectionsPandemicsdeviceMass screeningCoronavirusInvited ReviewClinical Laboratory TechniquesSARS-CoV-2COVID-19Reproducibility of ResultsClinical Laboratory Servicescoronavirus; device; instrument; portable; SARS-CoV-2 detection; Animals; Asymptomatic Infections; Betacoronavirus; Biomarkers; Clinical Laboratory Services; Clinical Laboratory Techniques; Coronavirus Infections; Disease Outbreaks; Humans; Mass Screening; Pandemics; Pneumonia Viral; Reproducibility of Results; Sensitivity and Specificity; WorkflowIdentification (information)030104 developmental biologyWorkflowRisk analysis (engineering)SARS‐CoV‐2 detectionCoronavirus InfectionsHost (network)Biomarkers030215 immunology
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Oxidation-Induced Increase In Photoreactivity of Bovine Retinal Lipid Extract

2017

Open access original paper Source : 10th EPR Workshop on Applications of EPR in Biology and Medicine, 2016 in Krakow, POLAND.; International audience; The mammalian retina contains a high level of polyunsaturated fatty acids, including docosahexaenoic acid (22:6) (DHA), which are highly susceptible to oxidation. It has been shown that one of the products of DHA oxidation-carboxyethylpyrrole (CEP), generated in situ, causes modifications of retinal proteins and induces inflammation response in the outer retina. These contributing factors may play a role in the development of age-related macular degeneration (AMD). It is also possible that some of the lipid oxidation products are photoreactiv…

0301 basic medicineretinaépithéliumLightOrganes des sensalpha-TocopherolBiochemistrysinglet oxygenchemistry.chemical_compoundspectrométrie de masseChromatography High Pressure Liquidrod outer segmentschemistry.chemical_classificationLiposomePhotorSuperoxideSinglet oxygenvitamine ephotorGeneral MedicineLipidsvertebrate retinaBiochemistryDocosahexaenoic acidAlimentation et Nutritionoxidized phospholipidsfatty-acid compositionRetina;Lipids;Polyunsaturated fatty acids;Oxidation;Photor;ROD OUTER SEGMENTS;GLYCATION END-PRODUCTS;SINGLET OXYGEN;PIGMENT EPITHELIUM;VITAMIN-E;MACULAR DEGENERATION;OXIDIZED PHOSPHOLIPIDS;MASS-SPECTROMETRY;VERTEBRATE RETINAOxidation-Reductionpolyunsaturated fatty acidsphospholipideSpectrometry Mass Electrospray IonizationChromatography Gasmacular degenerationoxidationrétineElectrospray ionizationvitamin-eSensory OrgansBiophysicsMédecine humaine et pathologieRetinalipids03 medical and health sciencesLipid oxidationZeaxanthinsacide gras polyinsaturé[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyOxidationAnimalsFood and NutritionlipideOriginal PaperReactive oxygen speciesChromatography030102 biochemistry & molecular biologyElectron Spin Resonance SpectroscopyoxydationRetinaldégénérescence maculaireCell Biologymass-spectrometryvertébrépigment epitheliumOxygen030104 developmental biologychemistryLiposomesglycation end-productsQuantum TheoryCattleSpin LabelsHuman health and pathologyPolyunsaturated fatty acidssense organs[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Jillian Russyll (AKA Jill) Tate

2018

030213 general clinical medicinemedia_common.quotation_subjectBiochemistry (medical)Clinical BiochemistryArt historyGeneral MedicineArt030204 cardiovascular system & hematology03 medical and health sciencesLaboratory Medicine0302 clinical medicineRicordoRicordo Laboratory Medicine RememberAKARemembermedia_commonClinical Chemistry and Laboratory Medicine (CCLM)
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Influence of label and location of testing on acceptability of cream cheese varying in fat content

1995

The acceptability of low-, medium- and high-fat versions of a cream cheese to consumers was measured in different conditions by rating overall distance from ideal. The influence of label (unlabelled vs. commercial package) differed according to the cream cheese fat-level habits of the assessors and to the fat level of the product. In labelled testing, high-fat cream cheese was more highly accepted by high- and medium-fat users and low-fat cream cheese seemed to be further from ideal for high-fat users. The location of testing (home vs. laboratory) affected the rating of only the high-fat product: consumers are more severe on it at home than in the laboratory.

0303 health sciencesFood intakeNutrition and Dietetics030309 nutrition & dieteticsFat contentFood Handling04 agricultural and veterinary sciencesCream cheeseConsumer Behavior040401 food scienceDietary Fats03 medical and health sciences[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition0404 agricultural biotechnologyfoodCheeseFood LabelingFood sciencefood.cheese[SDV.AEN]Life Sciences [q-bio]/Food and NutritionGeneral PsychologyFood AnalysisComputingMilieux_MISCELLANEOUSMathematics
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Detection of Candida albicans biofilm proteins induced by glucose, lactose, soy protein, and iron

2019

Background Oral candidiasis is one of the most common fungal infections, which attack the mucosa of the oral cavity. These lesions are mostly caused by the fungal species Candida albicans. Candida albicans is included in the normal oral microorganisms that are opportunistic pathogens, and its presence is quite large, which can reach 75% of the total oral fungal population. Research on specific proteins of Candida biofilm can be an alternative to early prevention of oral infections such as Oral Candidiasis. This biofilm protein can be used as a reference in making kits to detect the presence of microbes that cause infectious diseases. The purpose of this study was to determine molecular weig…

0303 health sciencesbiologyProtein band030306 microbiologyChemistryMicroorganismBiofilmExperimental laboratoryOral cavitybiology.organism_classification:CIENCIAS MÉDICAS [UNESCO]Microbiology03 medical and health scienceschemistry.chemical_compoundUNESCO::CIENCIAS MÉDICASLactoseCandida albicansGeneral DentistrySoy protein030304 developmental biology
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Effects of Food Label Health and Nutrition Claims on Consumer Perceptions

2009

Two experiments are reported that examined consumers' perceptions of food package labels where health and nutrition claims were present and where they had been removed. Unlike previous studies examining the influence of information on perception, realistic materials were used. This was accomplished by presenting information on a computer as photo-realistic images of packages where claims had been removed by editing to give a without-claims condition. Automatic presentation of materials and data collection meant participants proceeded through the computer questionnaire without the presence of an experimenter. The experiment was conducted with both British and French consumers. No significant…

0303 health scienceseducation.field_of_studyData collection030309 nutrition & dietetics[SDV]Life Sciences [q-bio]media_common.quotation_subjectPerspective (graphical)Population04 agricultural and veterinary sciences040401 food science[SDV] Life Sciences [q-bio]03 medical and health sciences0404 agricultural biotechnologyArgumentPerceptionFood choicePosition (finance)Food labelPsychologyeducationSocial psychologyComputingMilieux_MISCELLANEOUSMETHODOLOGIEhealth care economics and organizationsmedia_common
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La inclusión laboral de las personas con discapacidad desde la administración pública responsable en la Comunidad Valenciana

2020

En la presente coyuntura socioeconómica, la posibilidad de inclusión a través del empleo de las personas con discapacidad es importante no solo por las posibilidades de autonomía económica, sino también por las oportunidades de socialización. Sobre esta base, y considerando que las empresas socialmente responsables asumen la inclusión de estas personas en sus plantillas como una posibilidad de crecimiento y de diferenciación, en el texto se analiza, de manera descriptiva, el papel que las administraciones públicas (AA. PP.) autonómicas, con competencias en la materia, pueden, deben y están haciendo para fomentar la responsabilidad social corporativa (RSC) y la gestión de la inclusión labora…

030506 rehabilitationDiscapacitatsdiscapacidadSocial PsychologyPromoción de empleoCalidad de vidalcsh:BF1-990Españaresponsabilidad social corporativaSolidaridadEducationPolítica social03 medical and health sciencesCoping with disabilitySector públicolcsh:HD7255-72560501 psychology and cognitive scienceslcsh:Social sciences (General)AdministraciónHealth and Family05 social scienceslcsh:Vocational rehabilitation. Employment of people with disabilitiesinclusiónHacer frente a la discapacidadFamilia y SaludPsychiatry and Mental healthempleoinserciónlcsh:PsychologyInclusión laboralTrabajoDiscapacidadlcsh:H1-99ValenciaPshychiatric Mental Health0305 other medical science050104 developmental & child psychologyEmpresa
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