Search results for " Large"

Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.

2008

The proper function of the Scribble tumour suppressor complex is dependent upon the correct localisation of its components. Previously we observed dynamic relocalisation of the hDlg component under conditions of osmotic stress. We now show that the other two components of the complex, hScrib and Hugl-1 display similar patterns of expression. We demonstrate, by shRNA ablation of hScrib expression, that hDlg and Hugl-1 are in part dependent upon hScrib for their correct localization. However under conditions of osmotic stress this apparent dependency no longer exists: hDlg and Hugl-1 localise to cell membranes independently of hScrib. We also demonstrate an interaction between the three compo…

Dissecting the microenvironment of Splenic Marginal Zone Lymphoma and Diffuse Large B cell Lymphoma to find new stromal and immunological predictive …

Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling

2022

Abstract Background Autoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies. The matricellular protein osteopontin (OPN) has been linked to SLE pathogenesis, as SLE patients show increased serum levels of OPN and often polymorphisms in its gene. Although widely studied for its pro-tumorigenic role in different solid tumours, the role of OPN in autoimmunity-driven lymphomagenesis has not been investigated yet. Methods To test the role of OPN in the SLE-associated lymphomagenesis, the SLE-like prone Faslpr/lpr mutation was transferred onto an OPN-deficient background. Spleen from Faslpr/lpr and OPN-/-Faslpr/lpr …

Saules aktīvo apgabalu īpatnību pētījumi, izmantojot novērojumus mikroviļņu diapazonā

2013

Elektroniskā versija nesatur pielikumus

Hydraulic kinetics of the graft union in different Olea europaea L. scion/rootstock combinations

2007

The hydraulic resistance of young olive trees grafted on rootstocks with contrasting size-controlling potential was measured 30, 90, 360 and 480 days after grafting. Olive (Olea europaea L.) clones inducing plant vigorous growth (Leccino ‘Minerva’, LM) or dwarfing (Leccino ‘Dwarf’, LD) were studied in different scion/rootstock combinations (LD/LD, LD/LM, LM/LD, LM/LM). Plants growing on LD root systems developed lower leaf surface areas (about 50% less) than plants grafted on LM rootstocks. Graft union represented the largest fraction (up to 85%) of whole-plant hydraulic resistance 30 days after grafting, and still represented an important fraction of it 2 months later (40–55%). Four-hundre…

Analysis of a parabolic cross-diffusion population model without self-diffusion

2006

Abstract The global existence of non-negative weak solutions to a strongly coupled parabolic system arising in population dynamics is shown. The cross-diffusion terms are allowed to be arbitrarily large, whereas the self-diffusion terms are assumed to disappear. The last assumption complicates the analysis since these terms usually provide H 1 estimates of the solutions. The existence proof is based on a positivity-preserving backward Euler–Galerkin approximation, discrete entropy estimates, and L 1 weak compactness arguments. Furthermore, employing the entropy–entropy production method, we show for special stationary solutions that the transient solution converges exponentially fast to its…

Measurement of the forward-backward asymmetry of e(+)e(-)-]z-]b(b)over-bar using prompt leptons and a lifetime tag

1995

The forward-backward asymmetry of the process e+e-→Z→b {Mathematical expression} has been measured using events collected by the DELPHI experiment during the 1991 and 1992 LEP runs. This data sample corresponded to 884 000 hadronic Z decays at a centre-of-mass energy {Mathematical expression}. The tagging of b-quark events was performed using two approaches; the first was based on the semileptonic decay channels b→X+μ and b→X+e, the second used a lifetime tag with jet-charge reconstruction. The results of these two methods were combined to give {Mathematical expression} With the semileptonic sample, the forward-backward asymmetry of the process e+e-→Z→ {Mathematical expression} was also mea…

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

A Cohesive interface formulation in large displacements

2017

Mechanical interfaces are theoretical and computational tools able to properly reproduce the progressive decohesion along predefined surfaces. Scientific literature is rich of interface models, developed under very different conctitutive framework, but mostly developed in small displacements, whereas a few of them assess the problem in a geometrically nonlinear setting. In the present contribution interface formulation is rigorously developed in the large displacements regime. The relevant cohesive interface constitutive relations are defined in the local reference with normal and tangential axes to the middle surface in the current configuration. The interface is defined as a zero thicknes…

Forecasting energy output of a solar power plant in curtailment condition based on LSTM using P/GHI coefficient and validation in training process, a…

2022

This study presents how to improve the short-term forecast of photovoltaic plant's output power by applying the Long Short-Term Memory, LSTM, neural networks for industrial-scale solar power plants in Vietnam under possible curtailment operation. Since the actual output power does not correspond to the available power, new techniques (Global Horizontal Irradiance - GHI interval division, P/GHI factor addition (P - Power)) have been designed and applied for processing errors and missing data. The prediction model (LSTM network, structure of hidden layers, number of nodes) has been developed by the authors in a previous work. In this new version of the model, the training technique is improve…