Search results for " Levels"
showing 10 items of 483 documents
Relationships betweenin vitrodrug dissolution andin vivoresponse
2012
In recent years there has been an effort to relate manufacturing variables to the performance of the dosage form from a clinical point of view (in terms of safety and efficacy). Consequently any control strategy or the establishment of meaningful specifications should take into consideration the clinical impact on the patient. Since plasma levels are considered to be one of the most useful surrogates for clinical safety (in that bioequivalent plasma levels are considered therapeutically equivalent) and dissolution is the best surrogate for bioavailability, it is a natural consequence that dissolution be used to establish the design space in which all the formulations would have similar safe…
Efecto de la administración concomitante de indometacina o ibuprofeno en la farmacocinética de amikacina en neonatos prematuros
2006
Objective: To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug's pharmacokinetic parameters, and hence amikacin plasma levels. Method: Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearan…
Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis
2021
Background: Serum neurofilament light chain (sNfL) is a promising biomarker to complement the decision-making process in multiple sclerosis (MS) patients. However, although sNfL levels are able to detect disease activity and to predict future disability, the growing evidence has not yet been translated into practicable recommendations for an implementation into clinical routine. Methods: The observation of a patient with extensive inflammatory activity in magnetic resonance imaging (MRI) along with an extremely high sNfL level in the absence of any clinical symptoms prompted us to investigate common characteristics of our MS patients with the highest sNfL levels in a retrospective cohort st…
A Generalized Synthesis of 3-Amino-5-aryl-, 3-Amino-5-polyfluorophenyl-, and 3-Amino-5-alkyl-1,2,4-oxadiazoles through Ring-degenerate Rearrangements
2002
A generalized synthesis of 3-amino-5-aryl-, 3-amino-5-poly- fluorophenyl- and 3-amino-5-alkyl-1,2,4-oxadiazoles has been developed starting from the 3-amino-5-methyl-1,2,4-oxadiazole as a common synthon. Aroylation or alkanoylation of this aminooxadiazole, followed by thermally- induced ring-degenerate equilibration of resulting 3-acylamino compounds, and final acid hydrolysis of the 3-acetylamino-5-aryl- (or 5-polyfluorophenyl-), or 3- acetylamino-5-alkyl-1,2,4-oxadiazoles counterpart which is formed, gave the expected 3-amino-5-substituted 1,2,4-oxadiazoles. In the case of some 3- aroylamino compounds, yields of final 3-amino-5-aryloxadiazoles are higher than that expected on the basis of…
Variations of plas14a benin activity and aldostehone levels in the rat after administration of saline, chrystalloid and colloid solutions
1976
Abstract The data reported in the present paper refer to quantitative variations of plasma renin activity (PRA.) and of plasma aldosterone levels in rats after adiministration of saline, chrystalloid and colloid solutions. In our experimental conditions PRA and plasma aldosterone levels were shown to increase significantly after administration of distilled water and glucose solution. Variations of PRA and plasma aldosterone levels were only slight when plasma volume was made to increase due to administration of polyvinylpirrolidone solution. PRA, instead, was significantly lower in rats having received saline salution.
Existence of zero-energy impurity states in different classes of topological insulators and superconductors and their relation to topological phase t…
2015
We consider the effects of impurities on topological insulators and superconductors. We start by identifying the general conditions under which the eigenenergies of an arbitrary Hamiltonian H belonging to one of the Altland-Zirnbauer symmetry classes undergo a robust zero energy crossing as a function of an external parameter which can be, for example, the impurity strength. We define a generalized root of \det H, and use it to predict or rule out robust zero-energy crossings in all symmetry classes. We complement this result with an analysis based on almost degenerate perturbation theory, which allows a derivation of the asymptotic low-energy behavior of the ensemble averaged density of st…
Paleolimnological evidence of environmental changes in seven subtropical reservoirs based on metals, nutrients, and sedimentation rates
2021
Made available in DSpace on 2022-04-28T19:40:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01 Paleolimnological research can shed light on a broad range of environmental concerns; however, such studies are scarce in reservoirs. To address this lack of knowledge, a paleolimnological investigation was conducted to determine historical changes in sedimentation rates (SR), using 210Pb geochronology, and concentrations of nutrients and metals (Cr, Cu, Ni, Pb, Zn, Al, Mn, Fe) in seven subtropical reservoirs (São Paulo, Brazil). Sediment cores were collected in the dam areas. Increasing SR was observed in all reservoirs and was mainly attributed to eutrophication and changes in land…
On the photoelectron spectrum ofp-benzoquinone
2001
A high-resolution photoelectron spectrum of p-benzoquinone in the low energy (9.5–11.5 eV) region is reported and analyzed with the aid of simulations based on high-level ab initio calculations. The results generally support the notion that the two prominent spectral features in this region are each due to a pair of final ion states. The lower energy feature beginning near 10 eV is due to oxygen lone-pair ionizations, while that beginning near 11 eV comes from π electron removal. Contrary to previous interpretations of the spectrum, however, the results of this study indicate that the two π states are nearly degenerate, with the strongest peak in the photoelectron spectrum representing a co…
Jet-cooled FTIR spectroscopy and analysis of the C–O stretch fundamental of Ni(CO)4
2008
Rovibrational spectra of the C–O stretch band (ν5) of Ni(CO)4 have been recorded at 0.006 cm− 1 resolution by coupling a low pressure continuous supersonic jet with a high resolution interferometer. The spectrum has been analysed thanks to the STDS software (see http://icb.u-bourgogne.fr/OMR/SMA/SHTDS/) that implements the tensorial formalism developed in the Dijon group for tetrahedral molecules. We obtain a very satisfying simulation thanks to an effective Hamiltonian expanded up to order 3. The asymmetry of the high-J lines is due to a small tetrahedral splitting and is well reproduced. The root mean square deviation is 0.96 × 10− 3 cm− 1. The Coriolis constant is somewhat larger than fo…
Tensorial Development of the Rovibronic Hamiltonian and Dipole Moment Operators for XY3Z Molecules with a Degenerate Electronic State. Preliminary Ap…
2009
Abstract We present a development of the Hamiltonian and transition moment operators of XY3Z ( C 3 v ) symmetric tops molecules in a degenerate electronic state with the aid of a tensorial formalism developed in a recent paper [A. El Hilali, V. Boudon, M. Loete, J. Mol. Spectrosc. 239 (2006) 41–50]. Electronic operators are defined from group theory properties. They provide a new approach to build an effective rovibronic Hamiltonian as well as an effective dipole moment operator for rovibronic transition of XY3Z molecules. This model is studied qualitatively thanks to the tensorial algebra properties. Expressions of the matrix elements are derived for these operators. A first simple applica…