Search results for " Linear"

An approach to identify new antihypertensive agents using Thermolysin as model: In silico study based on QSARINS and docking

2019

Thermolysin is a bacterial proteolytic enzyme, considered by many authors as a pharmacological and biological model of other mammalian enzymes, with similar structural characteristics, such as angiotensin converting enzyme and neutral endopeptidase. Inhibitors of these enzymes are considered therapeutic targets for common diseases, such as hypertension and heart failure. In this report, a mathematical model of Multiple Linear Regression, for ordinary least squares, and genetic algorithm, for selection of variables, are developed and implemented in QSARINS software, with appropriate parameters for its fitting. The model is extensively validated according to OECD standards, so that its robust…

The Performance of the Gradient-Like Influence Measure in Generalized Linear Mixed Models

2015

A gradient-like statistic, recently introduced as an influence measure, has been proven to work well in large sample, thanks to its asymptotic properties. In this work, through small-scale simulation schemes, the performance of such a diagnostic measure is further investigated in terms of concordance with the main influence measures used for outlier identification. The simulation studies are performed by using generalized linear mixed models (GLMMs).

Estimating the temperature evolution of foodstuffs during freezing with a 3D meshless numerical method

2015

Abstract Freezing processes are characterised by sharp changes in specific heat capacity and thermal conductivity for temperatures close to the freezing point. This leads to strong nonlinearities in the governing PDE that may be difficult to resolve using traditional numerical methods. In this work we present a meshless numerical method, based on a local Hermite radial basis function collocation approach in finite differencing mode, to allow the solution of freezing problems. By introducing a Kirchhoff transformation and solving the governing equations in Kirchhoff space, the strength of nonlinearity is reduced while preserving the structure of the heat equation. In combination with the hig…

Bounds to internal forces for elastic-plastic solids subjected to variable loads

1979

Considering an elastic-plastic workhardening solid with piecewise linear yield surfaces and a piecewise linear workhardening law, we give a method for constructing bounds to the internal forces and to the (hardened) yield stresses produced by the action of variable loads at any point of the body and at any time. The loading history is supposed to be unknown, but the loads range within a given domain.

Image Encryption/Decryption system based on an oscillatory cellular nonlinear network

2008

International audience

Influence of the inter-particles elastic scattering on the quadratic-nonlinear Landau-Zener transition in photo- and magneto- association of ultracol…

2009

High bit rate optical pulses sources generation and microstructured chalcogenide fibers characterizations

2011

This memory of thesis s' registered voter in the context of the FUTUR project financed by l' ANR and concerning the development of optical functions for the high bit-rate transmissions in the Network heart and carries on very high rates optical fibers sources generation and the optical chalcogenide microstructured fiber characterization. For this purpose, we study the linear and non-linear characteristics of microstructured chalcogenide fibers conceived and realized in various collaborations within the framework of the ANR FUTUR project. For that a great number of characterizations methods were developed giving a comparison between a standard single mode fiber and these microstructured chal…

Delineating Aspects of Understanding Eigentheory through Assessment Development

2018

International audience; In this report, we share insights we have gained from developing an assessment for documenting students' understanding of eigentheory. We explain the literature and theory that influenced the assessment's development and share question examples. We frame our results in terms of three eigentheory settings (Ax = λx, (A - λI)x = 0, and eigenspaces) and four interpretations (numeric, algebraic, geometric, and verbal). Results from our analysis include students' reasoning being influenced by setting, insights into students' struggle with understanding eigenspaces, and the importance of making connections between and across various interpretations.

Etude des sources supercontinuum à fibres transparentes dans le moyen infrarouge

2012

The work reported in this thesis deals with the study of the supercontinuum generation in fibers transparent in the mid-infrared. To generate a supercontinuum between 3 and 5 µm we compare different glass families such as fluoride glasses, tellurite glasses and chalcogenide glasses. These fibers are pumped with fiber lasers emitting at 2 µm with nanosecond or picosecond pulse duration. This wavelength allows us to reach the zero dispersion wavelength of the chalcogenide tapered fibers. We report supercontinuum generation up to 3800 nm in a fluoride glass fiber. A connection with 75 % of transmission is made between a ZBLAN and a SiO2 fiber. We also measured absorption lines of the methane a…

High bit rate optical pulses sources generation and microstructured chalcogenide fibers characterizations

2011

This memory of thesis s' registered voter in the context of the FUTUR project financed by l'ANR and concerning the development of optical finctions fot the high bit-rate transmissions in the Network heart and carries on very high rates optical fibers sources generation and the optical chalcogenide microstructured fiber charaterization. For this purpose, we study the linear and non-linear characteristics of microstructured chalcogenide fibers conceived and realized in various collaborations within the framework of the ANR FUTUR project. For that a great number of characterizations methods were developed giving a comparison between a standard single mode fiber and there microstructured chalco…