Search results for " Linoleic acid"

showing 3 items of 33 documents

CLA, “new nutrients”?

2005

International audience; Conjugated linoleic acid (CLA) refers to a class of positional and geometric dienoic isomers of linoleic acid. Chronic dietary supplementation with commercial isomeric mixtures sold as dietary supplements leads to a drop in fat mass in various species. The t10,c12-CLA isomer is responsible for this antiobesity effect.The reduction of fat mass is especially dramatic in the mouse, in which it is associated with a severe hyperinsulinemia, an insulin resistance and a massive liver steatosis. The origin of these adverse side effects and the putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review. In Human, the…

lipoatrophyConjugated linoleic acid[SDV]Life Sciences [q-bio]insulino-résistanceMedicine (miscellaneous)food and beveragesNutritional statusInsulin resistanceCLABiochemistryMolecular biologyFat masschemistry.chemical_compoundchemistryFood supplementlipoatrophieInsulino resistancelipids (amino acids peptides and proteins)Conjugated linoleic acid[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFood Science
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Effects of dietary conjugated linoleic acids in the control of adiposity and obesity‐related disorders

2007

The body fat-lowering effect of conjugated linoleic acids (CLA) in experimental animals has attracted much interest because of the potential use of CLA as weight loss agents in humans. The objective of this review was to give an overview of the results from human intervention trials. The review also addresses experimental studies in animal models and in cultured cells. CLA appear to provoke fat mass loss and an increase of fat-free mass in rodents, but the results in humans are inconsistent and much less clear than in rodents. Thus, the results of studies in humans do not support a body fat-lowering effect of CLA. There are indications from animal studies that the trans-10, cis-12 CLA isome…

medicine.medical_specialtymedicine.medical_treatmentLinoleic acidConjugated linoleic acidBiologyIndustrial and Manufacturing Engineeringchemistry.chemical_compoundInsulin resistanceLiver steatosisInternal medicinemedicinechemistry.chemical_classificationintegumentary systemInsulinfood and beveragesGeneral Chemistrymedicine.diseaseObesityEndocrinologyBiochemistrychemistrylipids (amino acids peptides and proteins)Animal studiesFood ScienceBiotechnologyPolyunsaturated fatty acidEuropean Journal of Lipid Science and Technology
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Effet anti-obésité des CLA : mythe ou réalité ?

2005

Conjugated linoleic acids (CLA) are positional and geometric isomers of linoleic acid. Inclusion of CLA in the diet provokes a rapid and marked decrease in body weight gain and adiposity in mice leading to a lipoatrophic syndrome. However, CLA supplementation raised fasting blood glucose and insulin concentrations and was associated with severe insulin resistance and liversteatosis. Conflicting results have been reported with regard to reduction of fat mass in humans. We have reviewed the publish literature regarding the effect of CLA on body composition in humans and animal models. These studies indicate that t10-c12 was the isomer that reduced adipose fat storage, however it also increase…

obesitymedicine.medical_specialtymedicine.medical_treatmentConjugated linoleic acidAdipose tissuelcsh:TP670-699BiologyadipocyteBiochemistryliver steatosischemistry.chemical_compoundlipoatrophic diabetesInsulin resistanceInternal medicineAdipocytemedicinelipogenesisUnsaturated fatty acidLipoatrophic diabetesintegumentary systemInsulinFatty liverfood and beveragesmedicine.diseaseEndocrinologychemistrylipids (amino acids peptides and proteins)lcsh:Oils fats and waxesFood ScienceOléagineux, Corps gras, Lipides
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