Search results for " Literature."

showing 10 items of 2377 documents

A Simple Method to Predict Blood-Brain Barrier Permeability of Drug- Like Compounds Using Classification Trees

2017

Background: To know the ability of a compound to penetrate the blood-brain barrier (BBB) is a challenging task; despite the numerous efforts realized to predict/measure BBB passage, they still have several drawbacks. Methods: The prediction of the permeability through the BBB is carried out using classification trees. A large data set of 497 compounds (recently published) is selected to develop the tree model. Results: The best model shows an accuracy higher than 87.6% for training set; the model was also validated using 10-fold cross-validation procedure and through a test set achieving accuracy values of 86.1% and 87.9%, correspondingly. We give a brief explanation, in structural terms, o…

0301 basic medicineQuantitative structure–activity relationshipComputer scienceDatasets as TopicQuantitative Structure-Activity Relationshipcomputer.software_genre01 natural sciencesPermeability03 medical and health sciencesMolecular descriptorDrug DiscoveryInternational literatureComputer SimulationTraining setDecision tree learningDecision Trees0104 chemical sciences010404 medicinal & biomolecular chemistry030104 developmental biologyPharmaceutical PreparationsBlood-Brain BarrierTest setData miningBlood brain barrier permeabilitycomputerAlgorithmsDecision tree modelMedicinal Chemistry
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Systematic analysis of the scientific literature on population surveillance

2020

Abstract Introduction Population surveillance provides data on the health status of the population through continuous scrutiny of different indicators. Identifying risk factors is essential for the quickly detecting and controlling of epidemic outbreaks and reducing the incidence of cross-infections and non-communicable diseases. The objective of the present study is to analyze research on population surveillance, identifying the main topics of interest for investigators in the area. Methodology We included documents indexed in the Web of Science Core Collection in the period from 2000 to 2019 and assigned with the generic Medical Subject Heading (MeSH) “population surveillance” or its rela…

0301 basic medicinemedicine.medical_specialtyPopulationScientific literatureDiseaseBibliometricsOccupational safety and health03 medical and health sciences0302 clinical medicineResearch gapsPublic health surveillanceEnvironmental healthPandemicmedicinePublic health surveillancelcsh:Social sciences (General)lcsh:Science (General)educationDisease outbreaksPublic healtheducation.field_of_studyMultidisciplinarySubject areasPublic health030104 developmental biologyGeographyBibliometricslcsh:H1-99030217 neurology & neurosurgerylcsh:Q1-390Heliyon
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Validating the Spanish version of the aggression scale in adolescents

2021

The Scale of Physical and Verbal Aggressiveness has been an instrument widely used in the scientific literature to measure physical and verbal aggressiveness, both in children and adolescents as we...

05 social sciencesAggression Scale050109 social psychologySpanish versionScientific literaturebehavioral disciplines and activitiesConfirmatory factor analysisEducationVerbal aggressivenessScale (social sciences)Developmental and Educational Psychology0501 psychology and cognitive sciencesPsychology050104 developmental & child psychologyClinical psychologyInternational Journal of School & Educational Psychology
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Example Markers at the Intersection of Grammaticalization and Lexicalization

2020

Givon’s words “today’s morphology is yesterday’s syntax” have been widely used to describe grammaticalization, a process of linguistic change which implies an increase in the grammatical status of ...

050101 languages & linguisticsLinguistics and LanguageLiterature and Literary TheoryComputer scienceLexicalization05 social sciences06 humanities and the artsLinguistic change060202 literary studiesGrammaticalizationYesterdaySyntaxLinguisticsIntersection0602 languages and literature0501 psychology and cognitive sciencesEnglish Studies
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Towards a Science of the Self: Autism, Autobiography, and Animal Behavior in Temple Grandin’sAnimals in Translation

2019

AbstractThis paper argues that Temple Grandin’s work serves as an intervention into the very framework of ‘disability.’Animals in Translationsuggests that the minds of people living with autism are ‘wired differently’; yet, this difference, Grandin makes clear, is by no means always a disadvantage. As a scientist in animal studies and a consultant for animal behavior, Grandin claims that persons on the autism spectrum may be ideally suited for understanding the animal mind. Describing both autism and animal behavior through the discourse of neuroscience, she takes the analogy between persons with autism and animals one step further. Both animals, especially birds, and people on the autism s…

050101 languages & linguisticsLinguistics and LanguagePsychoanalysisLiterature and Literary TheorySelf05 social sciencesBiography06 humanities and the arts060202 literary studiesmedicine.diseaseLanguage and Linguistics0602 languages and literaturemedicineAutism0501 psychology and cognitive sciencesAnimal behaviorPsychologyZeitschrift für Anglistik und Amerikanistik
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Edición crítica, problemas textuales y de autoría: métrica y ortología en Lope de Vega

2021

Through examples taken from comedies recently attributed to Lope de Vega, this article deals with certain problems that should be considered when studying or editing plays of doubtful authorship. The analysis focuses on methods traditionally used to resolve problematic attributions, such as the study of versification, orthoepy and syllable counting. The conclusion argues that all of these tools —as well as the landmark works by Morley and Bruerton or W. Poesse — still offer great surprises and challenges for researchers. Thus, the development of new methods, such as stylometry, should not impel us to dismiss the classic approaches. Quite the opposite: old and new methods inform one another.

050101 languages & linguisticsOrthoepyPhilosophy0602 languages and literature05 social sciencesStylometryVega0501 psychology and cognitive sciences06 humanities and the artsSyllable060202 literary studiesCritical editionLinguistics
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Effectiveness of child protection practice models : a systematic review

2020

Background Attempts to improve child protection outcomes by implementing social work practice models embedded in a particular theory and practice approach, have increased internationally over the past decade. Objective To assess the evidence of the effectiveness of child protection practice models in improving outcomes for children and families. Participants and setting Children < 18 years and their families involved in child protection services. Methods A systematic review was conducted to synthesize evidence regarding the effectiveness of child protection practice models. Systematic searches across 10 electronic databases and grey literature were conducted to identify quasi-experimental s…

050103 clinical psychologymedia_common.quotation_subjectPoison controlchild protectiontoimintamallitOccupational safety and healthsystematic reviewInjury preventionDevelopmental and Educational PsychologyHumans0501 psychology and cognitive sciencesFamily10. No inequalityChildsystemaattiset kirjallisuuskatsauksetmedia_commonSelection biasMedical educationSocial worksocial workChild Protective Services05 social sciencesHuman factors and ergonomicsSocial SupportGrey literaturekäytäntöpractice modelssosiaalityöPsychiatry and Mental healthlastensuojeluChild protectionPediatrics Perinatology and Child HealthPsychology050104 developmental & child psychology
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An analysis of recent research on venture capital networks

2019

Purpose – this paper examines recent trends in venture capital network research. Network analysis is a useful approach for analyzing inter-organizational networks, especially for venture capitalists, which are characterized by plenty of connections. Although important steps ahead have been made, several research questions are still unanswered. Research methodology – this brief review analyses deeply three papers which are representative of the novel scientific literature in this field. Scrutinizing these works, I identify their points of strength and weaknesses, in order to understand how to pave the way for further research. Findings – this paper shows that the study of network weak ties a…

050208 financeKnowledge managementSettore SECS-P/11 - Economia Degli Intermediari Finanziaribusiness.industrymedia_common.quotation_subject05 social sciencesScientific literatureVenture capitalViewpointsInterpersonal tiesPrivate equityOriginalityOrder (exchange)Political science0502 economics and businessventure capital private equity network analysis venture capital investments risk management interorganizational networks venture capitalists’ reputation venture capital performance network weak ties.business050203 business & managementRisk managementmedia_commonProceedings of 6th International Scientific Conference Contemporary Issues in Business, Management and Economics Engineering ‘2019
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Los inventarios &lt;em&gt;post mortem&lt;/em&gt; de la Valencia medieval. Una fuente para el estudio del consumo doméstico y los niveles de vida

2017

Los inventarios post mortem de la Valencia bajomedieval apenas han sido sometidos a algunas cuestiones básicas sobre su naturaleza ¿Qué los distinguía de otras listas de bienes y cuál era su fundamentación legal? ¿Por qué se realizaban? ¿Qué bienes recogían y cuáles omitían? ¿Cuántos inventarios se conservan en la actualidad? ¿Qué sectores de la sociedad medieval los solicitaban? Las respuestas que proporciona este artículo hacen evidente la potencialidad de un uso seriado y cuantitativo del inventario valenciano para el estudio del consumo doméstico, una vía de análisis que permitiría medir con precisión cambios en los niveles de vida de la sociedad bajomedieval a un nivel muy difícil de l…

060104 history060201 languages & linguisticsConsumption (economics)HistoryGeographyWelfare economics0602 languages and literaturelanguage0601 history and archaeology06 humanities and the artsStandard of livingValencianlanguage.human_languageAnuario de Estudios Medievales
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Les rencontres improbables dans "les années 68"

2009

Resume Dans cette vaste periode de contestation que constituent les annees 68, des rencontres improbables se produisent. Celles-ci s’inscrivent dans la longue histoire des intellectuels desireux d’aller au peuple et notamment vers les ouvriers. Mais elles s’accelerent dans un certain nombre de mobilisations du debut des annees 1960. En mai-juin 1968, a la faveur de la desectorisation de l’espace social, ces rencontres improbables connaissent trois formes exemplaires : autour des ouvriers s’agregent ainsi des etudiants, des techniciens et des cadres, des paysans enfin. Celles-ci se prolongent dans les annees suivantes, notamment lors de grands conflits, tels Lip ou le Larzac. Toutefois, ces …

060104 historyHistory[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/Law0602 languages and literature0601 history and archaeology06 humanities and the arts060202 literary studiesComputingMilieux_MISCELLANEOUSannées 68[ SHS.DROIT ] Humanities and Social Sciences/Lawrencontres improbables
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