Search results for " Local"

Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG: not as bad as pr…

2018

PURPOSE: The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis to adequately stage and treat the patient. Persistent disease after TUR is not uncommon and is why re-TUR is recommended in T1G3 patients. When there is T1 tumor in the re-TUR specimen, very high risks of progression (82%) have been reported. We analyze the risks of recurrence, progression to muscle-invasive disease and cancer-specific mortality (CSM) according to tumor stage at re-TUR in T1G3 patients treated with BCG. METHODS: In our retrospective cohort of 2451 T1G3 patients, 934 patients (38.1%) underwent re-TUR. 667 patients had residual disease (7…

Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-al…

1993

A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24 h after epirubic…

p75NTRin the spleen: Age-dependent changes, effect of NGF and 4-methylcatechol treatment, and structural changes in p75NTR-deficient mice

2003

In addition to their well-known actions within the nervous system, neurotrophins and their receptors are involved in immune system functioning, as demonstrated by their wide distribution in lymphoid tissues and their in vitro actions on immunocompetent cells. Nevertheless, the in vivo roles of neurotrophin-receptor systems in lymphoid tissues, as well as the scope of their influence throughout development and adulthood, are yet to be clarified. In the present study, we used combined morphological and immunohistochemical techniques to investigate the presence and cellular localization of p75NTR, the pan-neurotrophin receptor protein, in rat spleen from newborns to aging individuals, and the …

Il paradigma della Smart Land nell’arcipelago Sicano

2017

Le Aree Interne, caratterizzate da poli rurali-urbani disconnessi tra loro, possono essere interpretate come arcipelaghi territoriali che, a differenza dei consolidati sistemi metropolitani, rappresentano ‘isole di eccellenza’, territori fertili non-gravitazionali su cui sperimentare nuove centralità, con specializzazioni funzionali che valorizzino le identità locali (uniche e non riproducibili) in forme innovative e attivare azioni di networking per produrre attrattività e competere nel contesto sovralocale. La ricerca presentata, che si inserisce nell’ambito dell’interesse ministeriale sulle Aree Interne, è finalizzata alla individuazione di sistemi rurali/urbani locali per ri-attivare il…

Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?

2021

RNA-binding proteins (RBPs) are critical players in RNA expression and metabolism, thus, the proper regulation of this class of proteins is critical for cellular health. Regulation of RBPs often occurs through post-translational modifications (PTMs), which allow the cell to quickly and efficiently respond to cellular and environmental stimuli. PTMs have recently emerged as important regulators of RBPs implicated in neurodegenerative disorders, in particular amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we summarize how disease-associated PTMs influence the biophysical properties, molecular interactions, subcellular localization, and function of ALS/FTD-linked …

Survival of patients treated with sorafenib for hepatocellular carcinoma recurrence after liver transplantation: A systematic review and meta-analysis

2014

Background: Data on survival and safety of sorafenib for hepatocellular carcinoma recurrence after liver transplant are still equivocal. Aim: We performed a meta-analysis of published studies, with the aim of estimating the 1-year rates of survival, analysing the variability in survival rates and, finally, identifying the factors associated with a longer survival. Methods: Data from 8 of the 17 selected studies were pooled, while the other 9 were excluded because survival rates were missing. All included studies were retrospective. Results: Overall, the 1-year survival ranged from 18% to 90%. Tumour progression was the main cause of death. The second cause was bleeding, reported only in pat…

HSP90 and eNOS partially co-localize and change cellular localization in relation to different ECM components in 2D and 3D cultures of adult rat card…

2007

Background information. Cultivation techniques promoting three-dimensional organization of mammalian cells are of increasing interest, since they confer key functionalities of the native ECM (extracellular matrix) with a power for regenerative medicine applications. Since ECM compliance influences a number of cell functions, Matrigel-based gels have become attractive tools, because of the ease with which their mechanical properties can be controlled. In the present study, we took advantage of the chemical and mechanical tunability of commonly used cell culture substrates, and co-cultures to evaluate, on both two- and three-dimensional cultivated adult rat cardiomyocytes, the impact of ECM c…

Genealogía y poder: invención de la memoria y ascenso social en la España Moderna

2004

Scelta varietale nei distretti tradizionali e nuovi areali

2019

Tonda di Giffoni, Tonda Gentile Romana e Tonda Gentile Trilobata: il panorama varietale italiano è piuttosto ristretto e anche le nuove aree in cui il nocciolo è in espansione puntano sulle cultivar tradizionali più apprezzate dall’industria. Ma dopo l’esperienza positiva della Tonda Francescana® alcune isolate iniziative di miglioramento genetico puntano ad ampliare la piattaforma varietale e clonale

Fractional differential calculus for 3D mechanically based non-local elasticity

2011

This paper aims to formulate the three-dimensional (3D) problem of non-local elasticity in terms of fractional differential operators. The non-local continuum is framed in the context of the mechanically based non-local elasticity established by the authors in a previous study; Non-local interactions are expressed in terms of central body forces depending on the relative displacement between non-adjacent volume elements as well as on the product of interacting volumes. The non-local, long-range interactions are assumed to be proportional to a power-law decaying function of the interaction distance. It is shown that, as far as an unbounded domain is considered, the elastic equilibrium proble…