Search results for " Local"

showing 10 items of 2101 documents

A fully automated method for accurate measurement of geometrical distortion in magnetic resonance imaging of a 3D-lattice phantom

2019

Abstract This paper describes an automated method for extracting the apparent positions of fiducial points from 2D or 3D images of a phantom. We consider a 3D-lattice phantom for two main reasons: first, ease of manufacture and isotropy of its structure with respect to coordinate projections; second, a connected structure allowing to uniquely assess the adjacency relationship between fiducial points even if geometric distortions arising from main magnet inhomogeneity and gradient fields non-linearity is severe as observed in open-bore systems. In order to validate our proposed method and compare different choices for the parameters of our phantom (i.e. number and distance between grids and …

Offset (computer science)RegistrationImage qualityComputer scienceBiomedical EngineeringBiophysicsImage enhancement/restoration (noise and artifact reduction)Signal-To-Noise RatioImaging phantomPattern Recognition Automated030218 nuclear medicine & medical imaging03 medical and health sciencesImaging Three-Dimensional0302 clinical medicineSoftwareRobustness (computer science)HumansComputer SimulationRadiology Nuclear Medicine and imagingMagnetic resonance imaging (MRI)Fiducial point localizationElectronic Data ProcessingPhantoms ImagingSettore ING-INF/03 - Telecomunicazionibusiness.industryAirSpherical harmonicsModels TheoreticalMagnetic Resonance ImagingPhantom designPersonal computerAdjacency listbusinessAlgorithmSoftware030217 neurology & neurosurgeryMagnetic Resonance Imaging
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report From the ILTS Transplant …

2020

Although liver transplantation (LT) is the best treatment for patients with localized hepatocellular carcinoma (HCC), recurrence occurs in 6%-18% of patients. Several factors, particularly morphological criteria combined with dynamic parameters, known before LT modify this risk and combined in prediction models may be used to stratify patients at need of variable surveillance strategies. Additional variables though likely explain differences in recurrence rates in patients with the same pre-LT HCC status. One of these variables is possibly immunosuppression (IS). Once recurrence takes place, management is highly heterogenous. Within the International Liver Transplantation Society Consensus …

OncologyAblation Techniquesmedicine.medical_specialtyCarcinoma HepatocellularConsensusmedicine.medical_treatmentConsensus Development Conferences as TopicMEDLINE030230 surgeryLiver transplantationMedical OncologyRisk Assessment03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineHumansIn patientGrading (tumors)Societies MedicalPostoperative CareTransplantationbusiness.industryLiver NeoplasmsConsensus conferenceImmunosuppressionChemoradiotherapy Adjuvantmedicine.diseasePrognosisUnited StatesLiver TransplantationQuality of evidenceEuropeTreatment OutcomeHepatocellular carcinomaPractice Guidelines as Topic030211 gastroenterology & hepatologyNeoplasm Recurrence Localbusiness
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Local and Regional Therapies for Hepatocellular Carcinoma.

2020

OncologyAblation Techniquesmedicine.medical_specialtyCarcinoma HepatocellularHepatologybusiness.industryLiver NeoplasmsMEDLINEmedicine.diseaseLiver TransplantationText miningHepatocellular carcinomaInternal medicineMedicineHumansChemoembolization TherapeuticNeoplasm Recurrence LocalbusinessHepatology (Baltimore, Md.)References
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HER2 amplification in recurrent breast cancer following breast-conserving therapy correlates with distant metastasis and poor survival.

2005

The authors analyzed the HER2 status in early-stage nonrecurrent and recurrent breast cancer groups following breast-conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patients were made. HER2 status was assessed by the HercepTest and fluorescence in situ hybridization. The Kaplan-Meier proportional log-rank test was used to study the impact of the biological factors on the metastasis-free interval (MFI) and the overall survival (OS). The Cox proportional hazards model, using stepwise selection was performed to identify the independent predictors o…

OncologyAdultCancer Researchmedicine.medical_specialtymedicine.medical_treatmentBreast NeoplasmsMastectomy SegmentalMetastasisBreast cancerTrastuzumabPredictive Value of TestsInternal medicinemedicineHumansNeoplasm Metastasisskin and connective tissue diseasesSurvival analysisIn Situ Hybridization FluorescenceAgedGynecologyProportional hazards modelbusiness.industryGene AmplificationGenes erbB-2Middle Agedmedicine.diseasePrognosisSurvival AnalysisOncologyPredictive value of testsFemaleNeoplasm Recurrence LocalbusinessBreast carcinomaMastectomymedicine.drugInternational journal of cancer
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Frequent chromosomal gains in recurrent juvenile nasopharyngeal angiofibroma.

2007

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor, mostly affecting adolescent males. Some patients develop recurrences after surgery independently of completeness of removal. Only very limited data concerning underlying chromosomal changes are available. We therefore analyzed samples of 22 JNAs, including six recurrences, with comparative genomic hybridization (CGH). Additionally, quantitative image cytometry was used for measurement of DNA aneuploidy in representative samples. Of the 13 primary JNAs without later recurrence, DNA gains were identified on autosomes in only two samples. Four patients with one or two recurrences were included in the study; for one of these, no…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyAdolescentJuvenile nasopharyngeal angiofibromaBiologyBioinformaticsAngiofibromaBenign tumorInternal medicineGeneticsmedicineHumansChildMolecular BiologyGeneChromosome AberrationsAutosomeNucleic Acid HybridizationNasopharyngeal NeoplasmsGenomicsDna amplificationmedicine.diseasePrimary tumorChromosome 4Neoplasm Recurrence LocalComparative genomic hybridizationCancer genetics and cytogenetics
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Cryotherapy for liver tumors: current status, perspectives, clinical results, and review of literature.

2004

Cryotherapy has gained importance as a locally ablative treatment option for patients with non-resectable liver tumors, especially metastases from colorectal cancer. We have used this technique since 1996 for the treatment of 77 patients with malignant liver tumors. Patient data was prospectively recorded and follow-up was until September 2002 or death. Fifty-five patients had colorectal cancer liver metastases, 16 metastases from other primaries and 6 had hepatoma. Forty patients had cryotherapy only and 37 had an additional liver resection. Morbidity and mortality were 22% and 1.3%, respectively. In 68% of patients with colorectal liver metastases and an elevated serum carcinoembryonic a…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyColorectal cancermedicine.medical_treatmentCryotherapyBreast NeoplasmsGastroenterologyCryosurgeryCryosurgeryResectionElevated serum03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansProspective StudiesNormal rangeAgedbusiness.industryLiver NeoplasmsPatient dataMiddle Agedmedicine.diseaseTreatment OutcomeOncology030220 oncology & carcinogenesis030211 gastroenterology & hepatologyFemaleNeoplasm Recurrence LocalbusinessColorectal NeoplasmsMedian survivalFollow-Up StudiesTechnology in cancer researchtreatment
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Effects of p63 expression on survival in oral squamous cell carcinoma

2007

BACKGROUND: P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell cycle regulation, and involved in the tumor differentiation. Aims of the present study were to assess the frequency and pattern of p63 protein expression in oral squamous cell carcinoma (OSCC) in relation to the main tumour characteristics and to verify whether p63 can be considered a marker of prognosis in patients with OSCC. MATERIAL AND METHODS: In a retrospective study, a cohort of 64 OSCC patients was investigated for p63 protein expression and its cellular localization by immunohistochemistry (monoclonal mouse anti-human p63 protein-clone 4A4). After grouping by p63 expression, …

OncologyAdultMaleCancer Researchmedicine.medical_specialtyPathologySurvival rateBiologyOSCCInternal medicinemedicineBiomarkers TumorCox regression analysisHumansGrading (tumors)GeneSurvival rateCellular localizationAgedNeoplasm StagingCox regression analysis; OSCC; p53 family; p63; Survival rate;p63integumentary systemTumor Suppressor ProteinsRetrospective cohort studyGeneral MedicineMiddle AgedPrognosisSurvival Analysisp63 p53 family OSCC Survival rate Cox regression analysisDNA-Binding Proteinsstomatognathic diseasesOncologyCohortMonoclonalCarcinoma Squamous CellTrans-ActivatorsImmunohistochemistryFemaleMouth NeoplasmsOSCCsense organsp53 familyp53 familyCox regressionTranscription Factors
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Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer.

2013

International audience; OBJECTIVE: To explore the risk of new or recurrent cancer among patients with IBD and previous cancer, exposed or not to immunosuppressants. DESIGN: Among the 17 047 patients of the CESAME prospective observational cohort who were enrolled from May 2004 to June 2005, and followed-up until December 2007, we identified 405 patients with cancer diagnosed previous to study entry. We calculated the rates of incident cancer in patients with or without previous cancer, and we assessed by survival analysis and nested case-control study the impact of immunosuppressants on the risk of incident new or recurrent cancer in patients with previous cancer. RESULTS: The rate of incid…

OncologyAdultMalemedicine.medical_specialtyAzathioprineKaplan-Meier EstimateCrohn Disease[ CHIM.ORGA ] Chemical Sciences/Organic chemistryRisk FactorsInternal medicineNeoplasmsEpidemiology of cancermedicineHumansProspective StudiesSurvival analysisAgedProportional Hazards ModelsCrohn's diseasebusiness.industry[CHIM.ORGA]Chemical Sciences/Organic chemistryIncidence (epidemiology)IncidenceGastroenterologyCancerMiddle Agedmedicine.diseaseUlcerative colitis3. Good healthSurgeryCase-Control StudiesCohortMultivariate AnalysisColitis UlcerativeFemaleNeoplasm Recurrence LocalbusinessImmunosuppressive Agentsmedicine.drugFollow-Up Studies
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Surrogate end points for overall survival and local control in neoadjuvant rectal cancer trials: statistical evaluation based on the FFCD 9203 trial.

2009

Abstract Background In resectable rectal cancer trials, pathological parameters are early preoperative treatment efficacy measures. Their validation as surrogate end points for long-term clinical outcomes would allow to reduce trial duration. The aim was to evaluate potential surrogates for overall survival (OS) and local control (LC) in preoperative T3/T4 rectal cancer trials. Candidate variables included ypT and ypN stages, T downstaging, tumor regression grade (TRG), and circumferential resection margin (CRM) status. Patients and methods In the Federation Francophone de Cancerologie Digestive (FFCD) 9203 trial, 742 eligible patients were randomly assigned to receive preoperative radiothe…

OncologyAdultMalemedicine.medical_specialtyColorectal cancermedicine.medical_treatmentAdenocarcinomaPreoperative careInternal medicinemedicineHumansNeoadjuvant therapyAgedRandomized Controlled Trials as TopicTumor Regression GradeAged 80 and overbusiness.industrySurrogate endpointRectal NeoplasmsHematologyMiddle Agedmedicine.diseaseChemotherapy regimenCombined Modality TherapyConfidence intervalNeoadjuvant TherapySurgeryClinical trialSurvival RateTreatment OutcomeOncologyFemaleNeoplasm Recurrence LocalbusinessBiomarkersAnnals of oncology : official journal of the European Society for Medical Oncology
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