Search results for " Local"

showing 10 items of 2101 documents

Is There a Role for Tertiary (TCR) and Quaternary (QCR) Cytoreduction in Recurrent Ovarian Cancer?

2015

BACKGROUND: The aim of the present study was to evaluate the efficacy of tertiary and quaternary cytoreduction in recurrent ovarian cancer patients. PATIENTS AND METHODS:Between January 1997 and December 2014, 53 patients were submitted to cytoreductive surgery for second and third ovarian cancer recurrence at our Unit. RESULTS:Median age at first diagnosis was 48 years (range=20-69). Forty-six patients (86.8%) underwent tertiary cytoreduction. At the time of surgery, isolated and diffuse disease was observed in 48 (90.6%) and 5 (9.4%) patients, respectively. Complete and optimal cytoreduction was obtained in 41 (77.5%) and in 1 (1.9%) patients, respectively. We did not observe any statisti…

Ovarian NeoplasmsAdultReoperationCytoreduction Surgical ProcedureMedicine (all)Ovarian NeoplasmTCR QCR cytoreductionRecurrent ovarian cancer; quaternary cytoreduction; tertiary cytoreduction; Adult; Aged; Cytoreduction Surgical Procedures; Female; Humans; Middle Aged; Neoplasm Recurrence; Local; Ovarian Neoplasms; Reoperation; Survival Analysis; Young Adultquaternary cytoreductionCytoreduction Surgical ProceduresMiddle AgedSurvival AnalysisYoung Adultovarian cancerSettore MED/40 - GINECOLOGIA E OSTETRICIAtertiary cytoreductionHumansFemaleSurvival AnalysiRecurrent ovarian cancerNeoplasm Recurrence Localquaternary cytoreduction; Recurrent ovarian cancer; tertiary cytoreduction; Medicine (all)AgedHuman
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miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance

2015

AbstractThe ErbB tyrosine kinase receptor family has been shown to have an important role in tumorigenesis, and the expression of its receptor members is frequently deregulated in many types of solid tumors. Various drugs targeting these receptors have been approved for cancer treatment. Particularly, in breast cancer, anti-Her2/EGFR molecules represent the standard therapy for Her2-positive malignancies. However, in a number of cases, the tumor relapses or progresses thus suggesting that not all cancer cells have been targeted. One possibility is that a subset of cells capable of regenerating the tumor, such as cancer stem cells (CSCs), may not respond to these therapeutic agents. Accumula…

P63cancer stem cellsCancer ResearchReceptor ErbB-2oncogenesmedicine.medical_treatmentmedicine.disease_causeTargeted therapyERBB3Molecular Targeted TherapyDEATHErbB ReceptorsGene Expression Regulation NeoplasticNeoplastic Stem CellsFemaleOriginal Articlemedicine.drugCARCINOMAMIGRATIONCancer Stem Cells; Breast CancerImmunologyBreast NeoplasmsCancer Stem CellMIR-205miR-205-5pBiologyLapatinibcancer treatmentNOCellular and Molecular Neurosciencebreast cancerBreast cancerErbBCancer stem cellCell Line TumormedicineHumansSUPPRESSIONCell ProliferationMESENCHYMAL TRANSITIONtumorigenesis cancer treatment cancer stem cells miR-205-5p oncogenes breast cancerMICRORNA EXPRESSIONTumor Suppressor ProteinsLapatinibCell BiologyTrastuzumabmedicine.diseaseGENEMicroRNAstumorigenesisDrug Resistance NeoplasmCancer cellQuinazolinesCancer researchNeoplasm Recurrence LocalCarcinogenesisTranscription FactorsCell Death & Disease
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Evaluer un dispositif d'accompagnement périscolaire : quelle mobilisation des acteurs pour quels résultats ?

2005

Actes édités sur support cédérom; En 1993, le Conseil Général des Hauts-de-Seine a mis en place un Plan pour la Réussite à l'Ecole et une Meilleure Insertion Sociale (PREMIS). Ce dispositif d'accompagnement péri-scolaire prend place hors du temps scolaire et se destine prioritairement aux collégiens en échec scolaire et/ou manifestant des comportements difficiles sur la base du volontariat. Cette action ne vise pas la remédiation cognitive mais cherche davantage à replacer l'élève sur une trajectoire propice à la réussite scolaire en modifiant ses attitudes à l'école et face aux savoirs. Dix ans après la mise en place de ce projet, la recherche-action engagée avec une équipe de chercheurs c…

PREMISPlan pour la Réussite à l'Ecole et une Meilleur Insertion Sociale[SHS.SOCIO]Humanities and Social Sciences/Sociology[SHS.SOCIO] Humanities and Social Sciences/Sociology[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationAccompagnement péri-scolaireEstime de soi[ SHS.EDU ] Humanities and Social Sciences/Education[ SHS.SOCIO ] Humanities and Social Sciences/SociologyDépartement des Hauts-de-SeineRecherche-actionEnseignement secondaireAction publique localeFranceEvaluationRapport au savoirRéussite scolaireDispositif éducatif
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Paesaggi locali

2009

Paesaggi localipiano paesaggistico AgrigentoSettore ICAR/21 - Urbanistica
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Agrigento: il sistema insediativo, le risorse territoriali e le vicende urbanistiche

2007

Panoramica del sistema urbano e paesaggistico della città di Agrigento attraverso una lettura del territorio, della storia antica e recente, degli elementi paesaggistici e monumentali, tanto nel sistema costruito quanto nel sistema naturale.

Paesaggio urbano territorio storicoSettore ICAR/15 - Architettura Del PaesaggioAgrigento sviluppo risorse territorio locale urbanisticaSettore ICAR/21 - Urbanistica
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Pérdida del último paisaje rural de la ciudad de Palma

2011

El conflicto socio ecológico, la ubicación del hospita l Son Espases en una zona rural de la ciudad de Palma, remite a tres aspectos fundamenta les: Uno, la desaparición del últim o paisaje nat ura l con re ferencias ar queológicas e históricas antiguas. Dos, una revita lización de la voz de la ciudadanía, en la defensa del Paisaje y del Patrim onio Cultural. Refleja la incorporación de expert os y del pa - pel de la ciencia en el conflicto, aunque siempre ha esta do presente en la historia de los conflictos ecológicos de Mallorca. Tres, el rol de los gobiernos. El conflicto surge con un gobierno del PP (2003-07) orienta do a los negocios del territorio. Hay un cambio al centro izquierda (2…

Paisaje:SOCIOLOGÍA::Sociología de los asentamientos humanos::Sociología rural [UNESCO]Patrimonio históricoPaisaje; Patrimonio históricoUNESCO::SOCIOLOGÍA::Sociología de los asentamientos humanos::Sociología rural:SOCIOLOGÍA::Sociología de los asentamientos humanos::Sociología local [UNESCO]UNESCO::SOCIOLOGÍA::Sociología de los asentamientos humanos::Sociología local
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Comparison of minimally invasive parathyroidectomy under local anaesthesia and minimally invasive video-assisted parathyroidectomy for primary hyperp…

2016

Background: Primary hyperparathyroidism (PHPT) origins from a solitary adenoma in 70-95% of cases. Moreover, the advances in methods for localizing an abnormal parathyroid gland made minimally invasive techniques more prominent. This study presents a micro-cost analysis of two parathyroidectomy techniques. Patients and methods: 72 consecutive patients who underwent minimally invasive parathyroidectomy, video-assisted (MIVAP, group A, 52 patients) or "open" under local anaesthesia (OMIP, group B, 20 patients) for PHPT were reviewed. Operating room, consumable, anaesthesia, maintenance costs, equipment depreciation and surgeons/anaesthesiologists fees were evaluated. The patient's satisfactio…

Parathyroidectomymedicine.medical_specialtyCostPrimary hyperparathyroidismmedicine.medical_treatmentVideo-Assisted Surgery03 medical and health sciences0302 clinical medicinePatient satisfactionmedicineHumansMinimally Invasive Surgical ProceduresGeneral anaesthesiaSicilyParathyroidectomyHyperparathyroidismbusiness.industryMinimally invasive parathyroidectomyOdds ratioHyperparathyroidism Primarymedicine.diseaseCosts; Minimally invasive parathyroidectomy; Primary hyperparathyroidism; SurgeryConfidence intervalSurgeryTreatment Outcomemedicine.anatomical_structurePatient Satisfaction030220 oncology & carcinogenesisCosts and Cost AnalysisOriginal ArticleSurgery030211 gastroenterology & hepatologyParathyroid glandbusinessPrimary hyperparathyroidismAnesthesia LocalGiornale di Chirurgia - Journal of Surgery
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Inscrire les contrats en alternance dans une logique de parcours sécurisé

2011

Ce rapport intermédiaire présente les premiers résultats du dispositif de tutorat assuré par les trois Missions locales de Côte-d'Or pour sécuriser le parcours des apprentis de l'hôtellerie-restauration, dans le cadre des expérimentations en faveur de la jeunesse mis en œuvre par le Haut Commissaire à la Jeunesse. Après avoir identifié les traits singuliers de l'industrie hôtelière en Bourgogne et présenté le cadre méthodologique innovant du dispositif, les particularités des apprentis de l'hôtellerie-restauration constituent le cœur du document. L'effet positif de la médiation menée par les Missions locales pour limiter les abandons de l'apprentissage et les départs du secteur est mis en l…

Parcours professionnelHôtellerie RestaurationCôte d'OrSécurisationApprentiPersonnel de l'hôtellerie et de la restauration[SHS.EDU] Humanities and Social Sciences/EducationIndustrie hôtelièreFranceTutoratMission locale
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Sécuriser les parcours des apprentis

2012

En ligne sur le site du Céreq : http://www.cereq.fr/index.php/content/download/6378/55371/file/b301.pdf; National audience; Les ruptures de contrat d'apprentissage sont fréquentes et réduisent les chances d'insertion sur le marché du travail. Pour sécuriser les parcours des apprentis, les accompagner dès leur entrée en formation, dans une logique préventive, est une solution efficace. C'est ce que montre l'évaluation d'une expérimentation réalisée auprès des jeunes et des employeurs par trois missions locales en Côte-d'Or.

Parcours professionnelHôtellerie RestaurationCôte d'OrSécurisationApprenti[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationPersonnel de l'hôtellerie et de la restaurationCommerce[ SHS.EDU ] Humanities and Social Sciences/EducationIndustrie hôtelièreTutoratMission locale
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Capitale territoriale e partenariato pubblico-privato: un'analisi dei fattori locali di successo

2013

Al centro di una possibile tassonomia del capitale territoriale si collocano le reti di cooperazione ed, in particolare, i servizi in partenariato pubblico-privato (PPP) che rappresentano beni e servizi ad un intermedio livello di materialità e rivalità. Questa categoria di beni consente di sfruttare le complementarietà tra pubblico e privato e, attraverso un complesso meccanismo di distribuzione del rischio e dei profitti tra i soggetti coinvolti, di accrescere l’efficienza complessiva dei progetti di investimento. Nel presente lavoro sono state analizzate le possibili determinanti territoriali degli esiti dei bandi di PPP promossi in Italia. Tali determinanti riguardano aspetti relativi a…

Partenariato pubblico-privatofattori localiCapitale territoriale
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