Search results for " Local"
showing 10 items of 2101 documents
Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management
2013
Dermatofibrosarcoma protuberans (DFSP) is a rare superficial tumor characterized by high rates of local recurrence and low risk of metastasis. DFSP occurs most commonly on the trunk and proximal extremities, affects all races, and often develops between the second and fifth decade of life. The tumor grows slowly, typically over years. Histologically, several variants of DFSP have been described and should be well characterized to avoid misdiagnosis with other tumors. These include pigmented (Bednar tumor), myxoid, myoid, granular cell, sclerotic, atrophic DFSP, giant cell fibroblastoma, and DFSP with fibrosarcomatous areas. Of all these variants, only the DFSP with fibrosarcomatous areas is…
Cytokeratin and Vimentin Expression in Primary and Recurrent Carcinoma of the Vulva
1996
Radical vulvectomy for the treatment of a vulvar carcinoma inevitably entails severe psychosexual consequences for the patients. Thus, for such tumors, reliable histological prognostic parameters are needed to allow; when appropriate, the use of less radical operative measures. One possible approach to this problem might be to examine tumors immunohistochemically for the presence of cytoskeletal components. To assess the utility of this method, we applied a panel of antibodies directed against cytokeratins (CKs) and vimentin to a groups of vulvar carcinomas (62 primary and 35 recurrent tumors) and examined the results for possible correlations with the course of disease and various clinical…
Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap : a case report with immunohistochemical findings
2010
Odontogenic ghost cell carcinoma (OGCC), a malignant counterpart of the odontogenic ghost cell tumor (OGCT), with aggressive growth characteristics, is exceedingly rare. A painful swelling in the jaw with local paresthesia is the most common symptom. We described a case of 47-year Korean woman who had a rare central epithelial odontogenic ghost cell carcinoma which recurred at reconstructed fibular flap. Immunohistochemical differences between OGCT and OGCC analyzed using primary and recurred surgical specimen. On the basis of this case, the tumor started as an OGCT and transformed into OGCC with highly aggressive, rapidly growing, infiltrative tumors. Our findings suggest that some of the …
Culture et patrimoine dans les municipalités : une communication politique en quête de consensus ? : enjeux démocratiques des questions culturelles e…
2017
This research falls mainly into the field of political communication. It tries to comprehend cultural and patrimonial questions as essentiel political communication issue in the municipalities in France. Having chosen two fields (Nice and Dijon), established a theoretical tool and a methodology, we started to hypothesize as follows : the political communication, relating to matters of culture and heritage in the local democratic life, builds up as two differing communication systems in each city. Our work draws on a corpus composed of semi-structured interviews with elected representatives, their speeches and other additional sources (speeches in the media, public and private archives of th…
La valorizzazione del patrimonio immobiliare quale leva strategica dei programmi Smart City
2014
Il lavoro propone un modello d’analisi a supporto dei processi di gestione strategica del portafoglio immobiliare degli enti locali. Esso assume il vincolo della carenza di risorse finanziarie e inquadra queste scelte nell’ambito delle iniziative “Smart City”, che consentono di coniugare la valorizzazione di questi asset immobiliari con gli obiettivi di promozione dell’innovazione e della competitività del territorio. This paper provides a theoretical model aimed at supporting the decision-making process for public real estate portfolio management. In a context of enduring financial constraints, Local Governments could manage the aforementioned process under the framework of the “Smart City…
Una nova planta per als valencians. Possibilitats i límits per a l'organització política i administrativa del País Valencià dins la Constitució de 19…
2013
Aquest estudi vol fer reflexionar el lector sobre la importància de la planta administrativa de les nostres institucions. Més de trenta anys després d’haver recuperat una Generalitat i un règim local que en gran part en depén, és hora d’avaluar críticament com hem desplegat aquestes estructures. L’actual context de crisi, econòmica però també social i política, a més, obliga a plantejar propostes de reforma per a bastir un model més eficaç, funcional, pròxim i democràtic. Ací s’ofereix un ampli ventall d’idees orientades a una radical transformació de la planta institucional valenciana. Un debat essencial perquè en la qualitat de les nostres institucions i accions públiques ens juguem, dire…
Out-of-the-box pelvic surgery including iliopsoas resection for recurrent gynecological malignancies: Does that make sense? A single-institution case…
2017
Abstract Objective To report morbidity and oncological outcomes in a consecutive series of lateral isolated recurrent gynecological cancer involving the pelvic side wall (PSW) including the iliopsoas muscle. Material and methods We retrospectively evaluated a consecutive series between 6/2013 and 12/2015 of lateral isolated recurrent gynecological malignancies treated with a lateral endopelvic resection (LEPR). LEPR was defined as an en-bloc lateral resection of a pelvic tumor with sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Post-surgical complications, quality of life (QoL) and survivals were computed. Results Seventy-four women with pelvic isolated r…
Pelvic exenteration for recurrent endometrial adenocarcinoma: a retrospective multi-institutional study about 21 patients.
2014
ObjectiveThe aim of our study was to evaluate morbidity, mortality, and long-term survival of patients who underwent pelvic exenteration (PE) with curative intent for recurrence of endometrial adenocarcinoma during a single decade.MethodsWe defined a cohort of 21 patients who met our inclusion criteria, referred to 4 cooperating gynecologic oncology settings in Germany and Italy between 2000 and 2011. Data regarding surgery, histology, and oncologic outcomes were collected and statistically evaluated. Survival was determined from the day of exenteration until the last follow-up or death.ResultsThe median age was 66 years. A total of 42.9% of the patients had major complications, and a compl…
Understanding the mechanism of non-polar diels-alder reactions. A comparative elf analysis of concerted and stepwise diradical mechanisms
2010
The electron-reorganization along the concerted and stepwise pathways associated with the non-polar Diels-Alder reaction between cyclopentadiene (Cp, 1) and ethylene (2) has been studied using the topological analysis of the electron localization function (ELF) at the B3LYP/6-31G(d) level of theory. ELF results for the concerted mechanism stresses that the electron-reorganization demanded on the diene and ethylene reagents to reach two pseudo-diradical structures is responsible for the high activation energy. A comparative ELF analysis of some relevant points of the non-polar Diels-Alder reaction between Cp and styrene (10) suggests that these concerted mechanisms do not have a pericyclic e…
Azo-hydrazo conversion via [1,5]-hydrogen shifts. A combined experimental and theoretical study
2012
Abstract Azoalkenes 6e , 6g , 6h , and 8c underwent an easy azo-hydrazo conversion via a [1,5]-hydrogen shift yielding α,β-unsaturated hydrazones. The isomerization products were characterized through spectroscopic and spectrometric techniques. In order to understand the nature of the mechanism of these [1,5]-hydrogen shifts, the transition state structures of the reactions were theoretically studied at the B3LYP/6-31G(d,p) level. Substitution effects in the propenylazo system on the kinetic and thermodynamic parameters were analyzed. An electron localization function (ELF) analysis of the electronic structure of the transition state structure associated with the azo-hydrazo conversion of t…