Search results for " Local"
showing 10 items of 2101 documents
Indigenous Research and Romantic Nationalism
2016
In recent years, “indigenous research” and “indigenous methods” have become prominent themes in the general field of qualitative methodology. These ideas and their implications raise serious questions for the wider conduct of social research. We will outline some of those ideas, subjecting them to scrutiny, and ultimately using them to question the rise of Romanticism in contemporary social methodology. We develop these ideas to question the contemporary emphasis on the personal and the experiential in current methodological commentary.
Minimum contrast for point processes' first-order intensity estimation
2023
In this paper, we exploit some theoretical results, from which we know the expected value of the K-function weighted by the true first-order intensity function of a point pattern. This theoretical result can serve as an estimation method for obtaining the parameter estimates of a specific model, assumed for the data. The only requirement is the knowledge of the first-order intensity function expression, completely avoiding writing the likelihood, which is often complex to deal with in point process models. We illustrate the method through simulation studies for spatio-temporal point processes.
Laparoscopic surgical management of localized recurrent ovarian cancer: a single-institution experience
2014
Background: Optimally, secondary cytoreduction is acknowledged as a valid option in terms of oncologic outcome for patients with platinum-sensitive recurrent ovarian cancer. In cases of localized relapse, a laparoscopic approach has been attempted at various institutions, but studies on its role for this subset of patients still are limited. This report describes the authors' experience using laparoscopic secondary cytoreduction for patients with localized recurrent ovarian cancer. The results from a retrospective analysis of a prospective case series are reported. Methods: Between October 2011 and May 2013, 29 patients with localized recurrent ovarian cancer were selected for a laparoscopi…
Unmet needs and gaps in the identification of secondary progression in multiple sclerosis: a Southern Italy healthcare professionals' perspective
2022
Abstract Objective Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. The relapsing–remitting MS presents acute onset and relapses of neurological symptoms, followed by their remission. This form can convert to secondary progressive MS (SPMS) with irreversible neurological worsening and disability. The identification of signs, symptoms, markers of progression, and strategies to manage MS patients is mandatory to allow early identification of those at higher risk of conversion to SPMS, for prompt intervention to cope with the progression of the disease. Methods A panel of Italian experts from Southern Italy have reviewed the current know…
L'estudi històric de les societats naturalistes en contexts locals: el cas valencià dins el cas espanyol
2004
Al llarg de les primeres dècades del segle XX, les activitats naturalistes al País Valencià assoliren un nivell reeixit pel que fa a llur qualitat i intensitat. Aquest fet anà acompanyat d'un desenvolupament considerable de l'associacionisme naturalista. L'article fa un resum d'aquest procés i l'insereix dins el context general d'Espanya. A més, suggereix algunes possibilitats per tal de portar llum, per mitjà d'aquest tipus d'estudis, a uns altres problemes relacionats amb la dimensió social del coneixement naturalista, com ara les relacions entre professionals i aficionats, la creació de coneixement general en un context local i la inserció del procés associatiu en les particularitats soc…
Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity.
2001
Changes occur in gene expression during aging in vivo and in replicative senescence in vitro, suggesting that aging can affect gene regulation. We have recently observed age-related changes in ubiquitously expressed, oxidative stress-responsive nuclear factor-kappa B (NF-kappa B) pathway during aging. Here we report a significant age-related increase in nuclear NF-kappa B binding activity together with increased protein levels of p52 and p65 components in rat liver. An additional, higher molecular weight protein band seen in their western blots suggests that their post-translational modification (but not phosphorylation) occurs in liver, which might affect their nuclear localization and bin…
Attenuation of NF-κB Signaling Response to UVB Light during Cellular Senescence
1999
The ability of cells to adapt to environmental stresses undergoes a progressive reduction during aging. NF-kappaB-mediated signaling is a major defensive system against various environmental challenges. The aim of this study was to find out whether replicative senescence affects the response of the NF-kappaB signaling pathway to UVB light in human WI-38 and IMR-90 fibroblasts. The exposure of early passage fibroblasts to UVB light inhibited the proliferation and induced a flat phenotype similar to that observed in replicatively senescent fibroblasts not exposed to UVB light. The UVB radiation dose used (153 mJ/cm2) did not induce apoptosis in either early or late passage WI-38 fibroblasts. …
Del acceso a la fragmentación del bienestar: Los servicios sociales de atención y desarrollo local en España
2018
Los Servicios Sociales son instrumentos al servicio de la política social para alcanzar objetivos de bienestar, calidad de vida y prosperidad de la población a que atienden. El presente documento muestra un breve repaso a la aparición de los Servicios Sociales en España, su génesis, evolución y la situación actual. Es objetivo del presente trabajo, mostrar la distinta implementación de los Servicios Sociales en el territorio español, dependiendo de la voluntad político-legislativa. Finalmente se destaca el preponderante papel de las rentas para la inserción de los usuarios de servicios sociales, la importancia de dimensionar la universalidad de los mismos como principio instaurador y la s…
The collaborative consistent vehicle routing problem with workload balance
2021
Abstract The rising competition in the logistics sector forces companies to be more economically efficient. One of the major sources of inefficiency is the incomplete usage of available resources, such as vehicles’ capacities. Mechanism that allow to better exploit such resources by enabling carrier collaborations are on the rise. Our study examines a centrally organized multi-period collaborative vehicle routing problem, where carriers can exchange customers who have to be serviced on a regular basis. Collaborations, where carriers serve frequent customers, are supposed to face the problem of (i) time consistency in terms of visiting time, and of (ii) service consistency. The latter ensure…
La racionalidad y la sostenibilidad como figuras míticas en el desmontaje del sistema público de servicios sociales
2014
Este artículo constituye un balance de los cambios que se están produciendo en el sistema de servicios sociales de la Comunidad Valenciana: 1) Una contextualización en un eje histórico que concluye con la actual búsqueda de un “consenso retrógrado” para desmontar el sistema público y los movimientos sociales de resistencia; 2) El desplazamiento de la contención social de la crisis desde el sistema de servicios sociales al de seguridad social; 3) Las transformaciones institucionales producidas por la vía presupuestaria; 4) El “efecto bumerang” sobre los Servicios Sociales que produce la implementación de la Ley de “promoción de la autonomía personal y apoyo a las situaciones de dependencia”;…