Search results for " Local"
showing 10 items of 2101 documents
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…
On the origin and diversification of Podolian cattle breeds: testing scenarios of European colonization using genome-wide SNP data
2021
AbstractBackgroundDuring the Neolithic expansion, cattle accompanied humans and spread from their domestication centres to colonize the ancient world. In addition, European cattle occasionally intermingled with both indicine cattle and local aurochs resulting in an exclusive pattern of genetic diversity. Among the most ancient European cattle are breeds that belong to the so-called Podolian trunk, the history of which is still not well established. Here, we used genome-wide single nucleotide polymorphism (SNP) data on 806 individuals belonging to 36 breeds to reconstruct the origin and diversification of Podolian cattle and to provide a reliable scenario of the European colonization, throug…
Temporal Fairness Provisioning in Multi-Rate Contention-Based 802.11e WLANs
2005
The IEEE 802.11e extensions for QoS support in WLAN define the transmission opportunity (TXOP) concept, in order to limit the channel holding times of the contending stations in the presence of delay-sensitive traffic. We evaluate the use of TXOP for a different purpose: "temporal fairness" provisioning among stations employing different data rates. We show that the equalization of the channel access times allows each station to obtain its throughput basically (1) proportional to its transmission rate, and (2) independent of the transmitted frame length. This also improves the aggregate throughput of the overall WLAN. For a given TXOP limit, i.e., a granted channel access time, a station is…
El impacto de la crisis en el empleo público local: el caso del área metropolitana de Valencia
2014
Los ajustes derivados de actual proceso de consolidación fiscal en que se hallan las Administraciones Públicas españolas han golpeado con fuerza a un entramado institucional débil: el empleo público de los gobiernos locales de nuestro país, explicable tanto por la fragilidad sobre el terreno del sistema de mérito, como por la falta de aplicación efectiva de mecanismos de gestión. En este contexto y transcurridos ya cinco años de crisis económica se trata de dar cuenta, mediante datos agregados y de un estudio realizado en el marco del proyecto SAIS-AMV (“sostenibilidad social y ambiental en espacios metropolitanos: el caso del área metropolitana de Valencia”), de qué modo, mediante qué estr…
Design and Implementation of Acoustic Source Localization on a Low-Cost IoT Edge Platform
2020
The implementation of algorithms for acoustic source localization on edge platforms for the Internet of Things (IoT) is gaining momentum. Applications based on acoustic monitoring can greatly benefit from efficient implementations of such algorithms, enabling novel services for smart homes and buildings or ambient-assisted living. In this context, this brief proposes extreme low-cost sound source localization system composed of two microphones and the low power microcontroller module ESP32. A Direction-Of-Arrival (DOA) algorithm has been implemented taking into account the specific features of this board, showing excellent performance despite the memory constraints imposed by the platform. …
Il reporting per segmenti nei settori del trasporto pubblico locale e della cura della salute. Esperienze a confronto.
2020
This paper examines issues of cost and revenue allocation that arise when segment reporting is carried out in local public transportation and healthcare companies. It also presents reports by segment schemes that can be used by companies operating in the aforementioned sectors. The research was carried out with the qualitative methods of participant observation and document analysis. this study focuses on the-oretical principles that have been derived from experiences carried out in the design and implementation of a segment reporting system in two companies operating in the public transportation and healthcare sectors. The analysis of the issues and solu-tions adopted by the companies obse…
TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
2015
Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be elucidated. In this study, we analyzed a set of patient-derived breast cancer stem cell (BCSC) lines. We found that in vitro BCSCs exhibit a higher chemoresistance and migratory potential when compared with differentiated, nontumorigenic, breast cancer cells (dBCCs). By developing an in vivo metastatic model simulating the disease of patients with early BC, we observed that BCSCs…
La cartolarizzazione dei crediti tributari degli enti locali: alcune questioni aperte
2017
Nell’ambito delle operazioni di cartolarizzazione aventi ad oggetto crediti della pubblica amministrazione, una delle questioni interpretative più delicate e tuttora aperte concerne la disciplina applicabile ai fini dell’individuazione dei contraenti coinvolti, ed in particolare del soggetto incaricato di assumere la veste di società veicolo. Alla complessità della questione non sembrerebbe, sino ad ora, essersi accompagnata un’approfondita riflessione dottrinale e giurisprudenziale sul tema, nonostante le evidenti ricadute applicative allo stesso connesse. Le successive considerazioni, pur riferite al limitato ambito della cartolarizzazione dei crediti tributari degli enti locali, scaturis…
Atomic emission and photon localization in 1D microcavity array
L'industrie microtechnique en Franche-Comté : un système productif complexe en cours de structuration
2007
This article reviews nearly four decades of change in the microtechnical industry of Franche-Comté. The case of the reconversion of French clockmakers, industrial districts in real crisis and territorial development around microtechnical industries, sheds invaluable light on the difficulties of restructuring an industry, despite the pressure of voluntary politics.