Search results for " Local"
showing 10 items of 2101 documents
Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials
2019
Abstract The Colorectal Cancer Subtyping Consortium identified four gene expression consensus molecular subtypes, CMS1 (immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal), using multiple microarray or RNA-sequencing datasets of primary tumor samples mainly from early stage colon cancer patients. Consequently, rectal tumors and stage IV tumors (possibly reflective of more aggressive disease) were underrepresented, and no chemo- and/or radiotherapy pretreated samples or metastatic lesions were included. In view of their possible effect on gene expression and consequently subtype classification, sample source and treatments received by the patients before collection must be ca…
Real-World Data Analysis of Pregnancy-Associated Breast Cancer at a Tertiary-Level Hospital in Romania
2020
Background and objectives: Breast cancer is among the most common cancer types encountered during pregnancy. Here, we aimed to describe the characteristics, management, and outcomes of women with pregnancy-associated breast cancer at a tertiary-level hospital in Romania. Material and Methods: We retrospectively and prospectively collected demographic, oncological, and obstetrical data for women diagnosed with cancer during pregnancy, and who elected to continue their pregnancy, between June 2012 and June 2020. Complete data were obtained regarding family and personal medical history and risks factors, cancer diagnosis and staging, clinical and pathological features (including histology and …
Not just BLAST nt: WGS database joins the party
2019
AbstractSince its introduction in 1990 and with over 50k citations, the NCBI BLAST family has been an essential tool of in silico molecular biology. The BLAST nt database, based on the traditional divisions of GenBank, has been the default and most comprehensive database for nucleotide BLAST searches and for taxonomic classification software in metagenomics. Here we argue that this is no longer the case. Currently, the NCBI WGS database contains one billion reads (almost five times more than GenBank), and with 4.4 trillion nucleotides, WGS has about 14 times more nucleotides than GenBank. This ratio is growing with time. We advocate a change in the database paradigm in taxonomic classificat…
Transfer of powers and reallocation of the social capital available to junior governments
1993
The article starts from the assumption that the production of junior governments in sub-central jurisdictions such as the department of the region is related both to the powers or resources that they receive from the central government and to the social capital which is available to them. A model is proposed in which both elements are considered as factors o f production. The second being able to move only slowly across levels of jurisdiction, the central government is itself unable to transfer rapidly powers or resources from one level to another without running the risk of an efficiency loss of the whole which it would find unacceptable in terms of electoral support.
Un estudio exploratorio sobre los presupuestos participativos infantiles en el ámbito local español
2022
Esta nota metodológica adelanta datos valiosos sobre una investigación en curso, cuyo objetivo fundamental es comprobar la validez de una serie de variables que sirvan para el estudio del fenómeno de presupuestos participativos infantiles en España durante un periodo comprendido entre el 2015 y el 2021. Al igual que ocurre con esta experiencia participativa en el ámbito adulto, su definición es complicada dada la adaptación de la metodología al entorno en el que se implementa. Para su conformación, se han realizado encuestas de pregunta abierta (35 respuestas válidas) que han sido estudiadas a través de un análisis de datos cualitativos y el uso del programa MAXQDA. La realización de este e…
[1,2,3]Triazolo[1,5-a]pyridines. A theoretical (DFT) study of the ring-chain isomerization
2008
The ring opening isomerization of [1,2,3]triazolo[1,5-a]pyridines to the corresponding 2-pyridyl derivatives has been studied by means of DFT calculations at the B3LYP/6-31+G(d,p) computational level. The effect of the substitution as well as those of protonation, deprotonation, and lithiation on different positions has been studied. The electronic characteristics of the optimized structures have been analyzed by means of the Atoms In Molecules (AIM), Electron Localization Function (ELF), Molecular Electrostatic Potential (MEP), and Natural Bond Orbital (NBO) methodologies. © 2008 Elsevier Ltd. All rights reserved.
La Copa del Mundo 2014 en Brasil: planificación urbana, desarrollo local y legado
2017
Desde el principio del siglo XXI, Brasil presentó importantes avances en términos económicos y sociales, además de un creciente protagonismo internacional. Así, la realización de la Copa 2014 sería la oportunidad para posicionarse estratégicamente como país capaz de emprender un evento de esta magnetud. El torneo envolvió un notable esfuerzo del gobierno entre los diferentes sectores del sector público y empresas privadas nacionales e internacionales, lo que implicó considerables inversiones en infraestructuras.Debido a la importancia de este evento, si se consideran los altos costes de emprender esta competición, si se tiene en cuenta la necesidad de justificar los gastos realizados y de p…
Design e valorizzazione della produzione locale
2011
Il testo esplora il tema del design per lo sviluppo locale, descrivendo un percorso di ricerca sul campo con l’esempio dello studio di un territorio siciliano. Lo studio, elaborato insieme con gli attori dello sviluppo territoriale (amministratori, Camera di Commercio, associazioni e imprenditori) della provincia di Ragusa, ha esplorato il rapporto tra il design e le risorse materiali e immateriali del territorio siciliano con l’obiettivo di sviluppare nuovi processi di produzione coerenti con il concetto di sostenibilità ambientale, per innovare e consentire una produzione sostenibile e costituire la base per un design “Made in Sicily”.
Chiral separation of bupivacaine enantiomers by capillary electrophoresis partial-filling technique with human serum albumin as chiral selector
2004
Abstract Capillary electrophoresis (CE) is a powerful technique for enantiomer separations due to its intrinsic high separation efficiencies, speed of analysis, low reagent consumption and small sample requirements. However, some chiral selectors present strong background UV absorption providing high detection limits. The present paper deals with the application of the partial-filling technique to the separation of bupivacaine enantiomers by capillary electrophoresis using human serum albumin (HSA) as chiral selector. In this procedure the cationic surfactant cetyltrimethylammonium bromide (CTAB) was used as a dinamic capillary coating in order to reduce the electro-osmotic flow and detect …
Electronic fluxes during diels-alder reactions involving 1,2-benzoquinones: mechanistic insights from the analysis of electron localization function …
2012
By means of the joint use of electron localization function (ELF) and Thom's catastrophe theory, a theoretical analysis of the energy profile for the hetero-Diels-Alder reaction of 4-methoxy-1,2-benzoquinone 1 and methoxyethylene 2 has been carried out. The 12 different structural stability domains obtained by the bonding evolution theory have been identified as well as the bifurcation catastrophes (fold and cusp) responsible for the changes in the topology of the system. This analysis permits finding a relationship between the ELF topology and the evolution of the bond breaking/forming processes and electron pair rearrangements through the reaction progress in terms of the different ways o…