Search results for " Low"
showing 10 items of 972 documents
Lower and Middle Cambrian brachiopods from the Iberian Chains and Sierra Morena (Spain)
2021
Brachiopods from the Lower and Middle Cambrian of the Iberian Chains and Sierra Morena are described. The following taxa occur in the Iberian Chains: "Lingulella" sp., Redlichella cf. bohemica (Barrande), Dictyonina radioplicata sp. n., Micromitra sp., Trematobolus simplex (Vogel), Trematobolus borobiensis sp. n. and Jamesella sp. The taxa "Lingulella" sp. and Sibiria? sp. are reported from the Lower Cambrian of Sierra Morena. Brachiopods constitute several distinct associations: the relatively shallow water Trematobolus assemblage near the Lower-Middle Cambrian boundary interval is followed by the deeper DictyoninaRedlichella assemblage. The alternation of these assemblages permit us to i…
Anti-PCSK9 treatment: Is ultra-low LDL always good?
2018
Anti-pcsk9 (proprotein convertase subtilisin kexin 9) monoclonal antibodies (Mab) are novel, potent lipid-lowering drugs. They demonstrated to improve the lipid profile in high cardiovascular risk patients. Anti-pcsk9 Mab inhibit the targeted LDL-receptor degradation induced by pcsk9 protein and are able to reduce LDL cholesterol (LDL-C) levels on top of conventional lipid-lowering therapy.Though these drugs proved to be very safe in the short term, little is known about the possible long term effects, due to the short period of their marketing. The genetic low-cholesterol syndromes (LCS) represent the natural models of the lipid-lowering anti-PCSK9 therapy, and a valuable opportunity to pr…
Rat Plasma VLDL Composition and Concentration and Hepatic Lipase and Lipoprotein Lipase Activities Are Impaired during Two Types of Protein Malnutrit…
1995
The relationships between VLDL concentrations and composition and changes in hepatic lipase and lipoprotein lipase activities were determined in rats, during the consumption of two low protein diets (2% casein or 5% gluten) (protein malnutrition) for 28 d, followed by the refeeding of a balanced diet for 14 d (15% casein) (refeeding). A control group was fed 15% casein for 42 d. In the control group, total lipolytic activity increased with age (r = 0.83, P < 0.001), whereas in both depleted groups, this activity remained low and stable throughout the period of protein malnutrition. At d 28 of protein malnutrition, plasma total lipolytic activities were significantly reduced in both depleted…
Smoking and small, dense low-density lipoproteins.
2013
LIPOPROTEIN SUBCLASS DISTRIBUTION IN DIFFERENT CLINICAL PATTERNS AND THEIR VARIATION AFTER THERAPY
Multi-Connectivity in 5G and Beyond Non-Terrestrial Networks
2022
The Fifth Generation (5G) communications systems aim to serve such service classes as Ultra-Reliable Low Latency Communications (URLLC), enhanced Mobile Broadband (eMBB), and massive Machine-Type Communications (mMTC). To meet the growing requirements posed to mobile networks, satellites can be used to complement the Terrestrial Networks (TNs). To increase the efficiency of the satellite communications involved, bandwidth-efficient techniques should be used. Multi- Connectivity (MC) is one such technique. In MC, a User Equipment (UE), for example, a smartphone, can be connected to multiple Next Generation Node Bs (gNBs) simultaneously. In this paper, an adaptive MC activation scheme for thr…
Effect of chest physiotherapy on cystic fibrosis sputum nanostructure: an experimental and theoretical approach.
2022
AbstractCystic fibrosis (CF) is a disease characterized by the production of viscous mucoid secretions in multiple organs, particularly the airways. The pathological increase of proteins, mucin and biological polymers determines their arrangement into a three-dimensional polymeric network, affecting the whole mucus and impairing the muco-ciliary clearance which promotes inflammation and bacterial infection. Thus, to improve the efficacy of the drugs usually applied in CF therapy (e.g., mucolytics, anti-inflammatory and antibiotics), an in-depth understanding of the mucus nanostructure is of utmost importance. Drug diffusivity inside a gel-like system depends on the ratio between the diffusi…
Guar gum/borax hydrogel: Rheological, low field NMR and release characterizations
2013
Guar gum (GG) and Guar gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) and model drug release tests. These three approaches are used to estimate the mesh size (ζ) of the polymeric network. A comparison with similar Scleroglucan systems is carried out. In the case of GGb, the rheological and Low Field NMR estimations of ζ lead to comparable results, while the drug release approach seems to underestimate ζ. Such discrepancy is attributed to the viscous effect of some polymeric chains that, although bound to the network to one end, can freely fluctuate among meshes. The viscous drag exerted by these chains slows down drug…
Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing
2012
We identified syntaxin 5 (Stx5), a protein involved in intracellular vesicle trafficking, as a novel interaction partner of the very low density lipoprotein (VLDL)-receptor (VLDL-R), a member of the LDL-receptor family. In addition, we investigated the effect of Stx5 on VLDL-R maturation, trafficking and processing. Here, we demonstrated mutual association of both proteins using several in vitro approaches. Furthermore, we detected a special maturation phenotype of VLDL-R resulting from Stx5 overexpression. We found that Stx5 prevented advanced Golgi-maturation of VLDL-R, but did not cause accumulation of the immature protein in ER, ER to Golgi compartments, or cis-Golgi ribbon, the main ex…
Paving the way for the Paris Agreement:Contributions of SDEWES science
2023
Today, coal is responsible for 40% of annual CO2 emissions. At the same time, global warming causes climate changes accompanied with catastrophic meteorological phenomena all over the world. After the 2015 Paris Agriment many countries set ambitious energy policy to reduce the annual greenhouse gas emission. The 2021 UN Climate Change Conference, COP26 - Glasgow, ended with the adoption of a less stringent resolution than some anticipated: countries only agreed to “phase down” rather than “phase out” coal. Is possible the realization of the Paris Agreement after COP-26? For achieving this ambitious targets in such conditions, the support of the multi-disciplinary scientific knowledge is nee…