Search results for " Low"

showing 10 items of 972 documents

New Frontiers in the Treatment of Homozygous Familial Hypercholesterolemia.

2021

: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder. The most common cause is a mutation in both alleles of the gene encoding for the low-density lipoprotein (LDL) receptor, although other causative mutations have been identified. Complications of atherosclerotic cardiovascular disease are common in these patients; therefore, reducing the elevated LDL-cholesterol burden is critical in their management. Conventionally, this is achieved by patients initiating lipid-lowering therapy, but this can present challenges in clinical practice. Fortunately, novel therapeutic strategies have enabled promising innovations in HoFH treatment. This review highlights recent and ongo…

Settore MED/09 - Medicina InternaGenetic enhancementHomozygous familial hypercholesterolemiaFamilial hypercholesterolemiaInclisiranBioinformaticsmedicine.disease_causeBenzimidazolePCSK9Hyperlipoproteinemia Type IIchemistry.chemical_compoundGene therapyAnticholesteremic AgentmedicineAngiopoietin-like 3HumansLow-density lipoprotein cholesterolAlleleAngiopoietin-like 3; Gene therapy; Gene-editing; Homozygous familial hypercholesterolemia; Inclisiran; Lomitapide; Low-density lipoprotein cholesterol; PCSK9MutationGene-editingAtherosclerotic cardiovascular diseasebusiness.industryPCSK9Anticholesteremic AgentsHomozygoteGenetic disorderGeneral MedicineCholesterol LDLmedicine.diseaseLomitapideLomitapidechemistrylipids (amino acids peptides and proteins)BenzimidazolesCardiology and Cardiovascular MedicinebusinessHumanHeart failure clinics
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Endoscopic Approach for Urinary Tract Pathologies

2022

Outline the real indications for the endo scopic procedure in pediatric urology. • Describe the instrumentation suitable for the endoscopy. • Describe the most used endoscopic techniques. • Report the results of endoscopic treatment. • Share tips and tricks of how to act endoscopicall

Settore MED/20 - Chirurgia Pediatrica E Infantileendoscopy lower urinary tract minimally invasive procedures
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TIROIDITE AUTOIMMUNE IN S. DI LOWE: SEGNALAZIONE DI UNA NUOVA ASSOCIAZIONE

2009

Settore MED/38 - Pediatria Generale E SpecialisticaSindrome di Lowe Insufficienza renale tiroidite autoimmune
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Short and middle term effects of hypocaloric low carbohydrate diet vs hypocaloric Mediterranean diet on endothelial function in obese subjects

2008

Adequate nutritional treatment is required to address the problem of increasing prevalence of obesity in Western countries. The Mediterranean diet style is now acknowledged to have large scientific evidences in terms of cardiovascular prevention. However, many popular diets are diffusing also as self-prescribed treatments. Among those, the efficacy of low-carbohydrate diets (also known as Atkins’ diet in its most popular variety) has been addressed by some investigations. It is generally concluded that the low-carbohydrate diet is able to induce a greater weight loss, at least in the middle term, and a better serum lipid profile than the conventional diet. In this longitudinal, randomised, …

Settore MED/49 - Scienze Tecniche Dietetiche ApplicateMEDITERRANEAN DIET ENDOTHELIAL FUNCTION OBESITY LOW CARBOHYDRATE DIETSettore MED/13 - Endocrinologia
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Design and analysis of discrete choice experiments for models with response time

2013

Settore SECS-S/02 - Statistica Per La Ricerca Sperimentale E TecnologicaA sector of conjoint analysis (experimental design in marketing research) is made of the so called choice experiments. In choice experiments respondents undergo a questionnaire which is nowadays mostly submitted through the internet. The questionnaire proposes to the respondent a sequence of choice sets each one including two or more profiles being a profile a specific combination of attribute levels. The respondent selects the preferred profile for each choice set. Responses given by a sample of respondents are analysed through suitable methods aimed to eventually find the best combination of attribute levels. One method of analysis adopts the Multinomial Logit (MLN) model. In this article the authors show the results of the MLN analysis compared with another model of analysis which uses an additional response which can be easily recorded by electronically submitted questionnaires. In practice modern survey platforms like “Qualtrics” (the one used for this work) can record the so called “response latency” i.e. the time taken by the respondent to make the choice and select the most preferred profile in the choice set. Thanks to a response latency model further refined in this work it is possible to deduce the relative weight of importance of the profiles for each choice set and respondent. This type of response can be used in place of the dichotomous choice variable in the MLN model. The two models and methods of analysis are deeply compared and it is critically discussed when it is better to use one or the other method. As a result a more reliable estimate of the optimal profile comes up implying lower risks for new investments and marketing decisions.
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SHEAR BEHAVIOUR OF MOLTEN LINEAR LOW DENSITY POLYETHYLENE.

1984

The rheological behaviour of molten polyethylene has been widely studied especially with respect to the different structure of the high density and low density samplesI–I0. In particular it is well known that the presence in the LDPE of long chain branching alters dramatically the whole flow curve, the activation energy, the die-swell, the instability phenomena, etc.

Shear rateLinear low-density polyethyleneLow-density polyethylenechemistry.chemical_compoundMaterials scienceRheologychemistryActivation energyComposite materialPolyethyleneBranching (polymer chemistry)Instability
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Numerical approach for signal delay in general distributed networks

2003

The authors consider a general network with telegraph equations modelling distributed elements and having, additionally, nonlinear capacitors. A global asymptotic exponential stability of the solution is given. A simple computable upper bound of the delay time is given. Numerical examples illustrate the usefulness of the results. >

Signal delayNumerical analysisMathematical analysisTime-scale calculusLambdaUpper and lower boundslaw.inventionNonlinear capacitanceCapacitorTheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESIntelligent NetworkExponential stabilityControl theorySimple (abstract algebra)lawApplied mathematicsDelay timeHardware_LOGICDESIGNMathematicsNetwork analysisVoltage[1987] NASECODE V: Proceedings of the Fifth International Conference on the Numerical Analysis of Semiconductor Devices and Integrated Circuits
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Small, dense low-density lipoproteins are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome.

2008

Small dense low-density lipoproteins cardiovascular events the metabolic syndrome.aterosclerosi
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1990

The countercurrent extraction method recently developed for the continuous polymer fractionation (CPF) was applied to linear polyethylene (Mw = 55 kg/mol; Mn = 16,7 kg/mol). At temperatures higher than 130°C, moderately concentrated solution of polyethylene were extracted to remove the low-molecular-weight components. Discontinuous fractionation experiments served to detect the best suited solvents. Diphenyl ether was chosen to demonstrate that the present extraction can be performed even with the same single solvent used to prepare the feed. For very high-molecular-weight polymers, mixed solvents are, however, normally better than single ones, since they allow an easier tailoring of thermo…

Solventchemistry.chemical_classificationLinear low-density polyethylenechemistry.chemical_compoundchemistryExtraction (chemistry)Polymer chemistryFractionationPolymerPolymer fractionationPolyethyleneTriethylene glycolDie Makromolekulare Chemie
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Gamma-induced background in the KATRIN main spectrometer

2019

The KATRIN experiment aims to measure the effective electron antineutrino mass $$m_{\overline{\nu }_e}$$ mν¯e with a sensitivity of $${0.2}\,{\hbox {eV}/\hbox {c}^2}$$ 0.2eV/c2 using a gaseous tritium source combined with the MAC-E filter technique. A low background rate is crucial to achieving the proposed sensitivity, and dedicated measurements have been performed to study possible sources of background electrons. In this work, we test the hypothesis that gamma radiation from external radioactive sources significantly increases the rate of background events created in the main spectrometer (MS) and observed in the focal-plane detector. Using detailed simulations of the gamma flux in the e…

Speichertechnik - Abteilung BlaumPhysics - Instrumentation and Detectorsgamma ray: backgroundshieldingshielding: magneticPhysicsFOS: Physical scienceslcsh:AstrophysicsInstrumentation and Detectors (physics.ins-det)electron: secondarysensitivityKATRINbackground: lowlcsh:QB460-466electron: backgroundlcsh:QC770-798lcsh:Nuclear and particle physics. Atomic energy. Radioactivityddc:530gamma ray: flux[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Electromagnetismonumerical calculationselectrostatic
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