Search results for " Ly"
showing 10 items of 2487 documents
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets
2020
Autosomal recessive mutations in genes required for cytotoxicity are causative of a life-threatening, early-onset hyperinflammatory syndrome termed familial hemophagocytic lymphohistiocytosis (FHL). Mutations in UNC13D cause FHL type 3. UNC13D encodes Munc13-4, a member of the Unc13 protein family which control SNARE complex formation and vesicle fusion. We have previously identified FHL3-associated mutations in the first intron of UNC13D which control transcription from an alternative transcriptional start site. Using isoform specific antibodies, we demonstrate that this alternative Munc13-4 isoform with a unique N-terminus is preferentially expressed in human lymphocytes and platelets, as…
B lymphocyte intestinal homing in inflammatory bowel disease.
2011
Abstract Background Inflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically natural antibodies but pathologically atypical anti-neutrophil antibodies (xANCAs) are frequently observed in patients with IBD. The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features. Methods The IPCs in small intestinal, colonic and rectal biopsy specimens of patients with IBD were analysed by means of immun…
Diagnosis of exon 12‐positive polycythemia vera rescued by NGS
2020
Abstract A JAK2V617F‐negative polycythemia associated with low serum epo needs to be tested for an exon 12 JAK2 mutation. When negative, due to potential serious complications in PV, a next generation sequencing is necessary to rule out false negative results.
Adaptations to thermal variation in two Mediterranean limpets - cardiac response and haemocyte lysosomal stability
2012
Patella rustica and Patella caerulea are two congeneric limpet species, both occurring along the rocky shores of the Mediterranean but on different tidal heights. P. rustica is dominant in the upper intertidal zone while P. caerulea is more abundant in the lower part of the same zone. Understanding variations in physiological adaptations to thermal stress is vital when investigating intertidal species' distribution. Hence, to investigate the relationship between their physiological thermal tolerance and intertidal zonation, laboratory experiments were designed to test the hypothesis that the lower zoned P. caerulea has reduced upper thermal limits when compared with higher zoned P. rustica,…
A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.
2015
Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …
Colori dell'eros nelle Grecia antica
2020
L’articolo contiene una dettagliata indagine di alcuni termini di colore (poikìlos, chloròs, erythròs, pòrphyros e loro composti), di cui si esamina l’uso e i significati nel confronto tra lirica greca arcaica e letteratura medica, con particolare attenzione per i contesti erotici. In accordo con quanto già evidenziato da altri studiosi, emerge in generale l’estensione e l’innovazione, da parte di lirici e medici, del tradizionale ambito culturale e semantico di tali termini, a discapito del mero tratto coloristico. Specificamente, il confronto tra l’uso poetico e medico, specie ippocratico, dei termini di colore considerati mostra alcune corrispondenze nella rappresentazione e nell’immagin…
Breast Cancer-Related Lymphedema: Prevalence, Risk Factors and Surgical Treatment
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Autophagy
2021
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide…