Search results for " MARS"

showing 10 items of 163 documents

Situación de las poblaciones valencianas del género Marsilea: medidas para su conservación

2001

elena.estrelles@uv.es ana.ibars@uv.es Juan.J.Herrero@uv.es Se analiza la situación de las poblaciones valencianas de Marsilea batardae, M. quadrifolia y M. strigosa, así como las amenazas que actualmente pesan sobre ellas. Asimismo se comentan las medidas que se han puesto en marcha para asegurar su conservación, entre las que destacan las introducciones experimentales. The situation of Valencian populations of Marsilea batardae, M. quadrifolia and M. strigosa, as well as the threats that they suffer at present are analysed here. Likewise the measures applied to ensure their conservation, with emphasis on the experimental introductions, are commented.

:CIENCIAS DE LA VIDA::Biología vegetal (Botánica) [UNESCO]Conservation ; Marsilea batardae ; M. quadrifolia ; M. strigosaM. quadrifoliaConservaciónConservación ; Marsilea batardae ; M. quadrifolia ; M. strigosaMarsilea batardaeConservationM. strigosaUNESCO::CIENCIAS DE LA VIDA::Biología vegetal (Botánica)
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Zvaigžņotā Debess: 2009, Rudens (205)

2009

Contents: I.Daube. Jānis Ikaunieks ; A.Balklavs. Mountains on the Venus ; TASS and “Pravda” materials. Soviet Automatic Stations “Venera-5” and “Venera-6” Reach Venus ; A.Alksnis. Gathering of Astronomers at the University ; A.Alksnis, M.Ābele, I.Eglītis, B.Rjabovs, K.Salmiņš, I.Pundure. Directions of Scientific Research of the UL Institute of Astronomy Assessed ; D.Docenko. Meteorite Fallen in Sudan Recovered ; A.Alksnis. How Asteroids Will Disturb Observation with Extremely Large Telescopes ; M.Gills. Daily in Network with Astronomy ; I.Pundure. Arturs Balklavs and Astronomy of Latvia (continued) ; M.Sudārs. IXV – Step towards Reusable Space Vehicles ; V.Kalniņš. Hyperdrive and Heim’s Qua…

Asteroīdi un novērošana ar lielajiem teleskopiemAlfrēds Štrauss – dzīvesstāsta meklējumiAndromedas galaktika M31Vienošanās starp Latvijas valdību un Eiropas Kosmosa aģentūruMeteorīts Almahatta SittaArturs Balklavs “Latvijas astronomija pēc Trešās atmodas”IXV – Eiropas daudzkārt izmantojams kosmosa kuģisLatvijas atklātā matemātikas olimpiādeRainis – kosmosa dzejnieksJānis IkaunieksAstronomu salidojums UniversitātēSiltumnīcas uz MarsaAstronomiskās parādības - 2009Latvijas astronomija - vēstureStarptautiskais Astronomijas gads 2009 – plakātsAstronomijas institūts - zinātniskā pētniecībaJaunākie žurnāli “Zvaigžņotās Debess” bibliotēkāEduards Riekstiņš – 90LU fizikas docents Ludvigs Jansons – 100Hiperdzinējs – Heima kvantu teorijaAgreement between the Government of the Republic of Latvia and the European Space AgencyAstronomija - tīmeklīRīgas Politehnikuma Astronomijas kabinets – 130Latvijas atklātā skolēnu astronomijas olimpiāde
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Report of the COSPAR Mars special regions colloquium

2010

International audience; In this paper we present the findings of a COSPAR Mars Special Regions Colloquium held in Rome in 2007. We review and discuss the definition of Mars Special Regions, the physical parameters used to define Mars Special Regions, and physical features on Mars that can be interpreted as Mars Special Regions. We conclude that any region experiencing temperatures > -25 degrees C for a few hours a year and a water activity > 0.5 can potentially allow the replication of terrestrial microorganisms. Physical features on Mars that can be interpreted as meeting these conditions constitute a Mars Special Region. Based on current knowledge of the martian environment and the conser…

Atmospheric Science010504 meteorology & atmospheric sciencesPlanetary protectionLiquid waterAerospace EngineeringTerrainBACTERIAL-ACTIVITY01 natural sciencesSPACECRAFT SURFACESAstrobiologyWater-vaporSouth-pole snow0103 physical sciencesBacterial activitySpace research010303 astronomy & astrophysicsBacterial activity0105 earth and related environmental sciencesMartianCommittee on Space ResearchCOSPAR mars special regions colloquiumNear-surfaceAstronomy and AstrophysicsMars Exploration Program15. Life on landGround ice[PHYS.PHYS.PHYS-SPACE-PH]Physics [physics]/Physics [physics]/Space Physics [physics.space-ph]GeophysicsLiquid water13. Climate actionSpace and Planetary ScienceGeneral Earth and Planetary SciencesHigh obliquitySea-iceUpper martian surfaceSpace-craft surfacesGeology
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FIDO science payload simulating the Athena Payload

2002

[1] The Jet Propulsion Laboratory's Field Integrated Development and Operations rover (FIDO) emulates and tests operational rover capabilities for advanced Mars rover missions, such as those originally planned for the Mars Surveyor 2001 Rover and currently planned for the Athena Payload on the Mars Exploration Rovers scheduled for launch in 2003. This paper describes FIDO's science instrument payload, which is fully integrated with rover hardware and software. Remote science teams visualize instrument suite data and generate FIDO commands using the Web Interface for Telescience. FIDO's instrument suite has been used in terrestrial laboratory and field tests to simulate Mars operations, to t…

Atmospheric ScienceComputer scienceSoil ScienceAquatic ScienceOceanographyExploration of Marslaw.inventionSoftwareGeochemistry and PetrologylawEarth and Planetary Sciences (miscellaneous)Earth-Surface ProcessesWater Science and TechnologyRemote sensingEcologySpectrometerbusiness.industryPaleontologyForestryMars Exploration ProgramRobot end effectorMars roverGeophysicsStereo imagingSpace and Planetary ScienceRadiancebusinessJournal of Geophysical Research: Planets
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Spirit Mars Rover Mission: Overview and selected results from the northern Home Plate Winter Haven to the side of Scamander crater

2010

Spirit Mars Rover Mission : Overview and selected results from the northern Home Plate Winter Haven to the side of Scamander crater

Atmospheric ScienceEcologyEarth sciencePaleontologySoil ScienceMars exploration roverForestryMars Exploration ProgramAquatic ScienceOceanographyExploration of MarsHavenAstrobiologyMars roverGeophysicsImpact craterSpace and Planetary ScienceGeochemistry and PetrologyEarth and Planetary Sciences (miscellaneous)GeologyEarth-Surface ProcessesWater Science and TechnologyJournal of Geophysical Research
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Geochemical and mineralogical indicators for aqueous processes in the Columbia Hills of Gusev crater, Mars

2006

[1] Water played a major role in the formation and alteration of rocks and soils in the Columbia Hills. The extent of alteration ranges from moderate to extensive. Five distinct rock compositional classes were identified; the order for degree of alteration is Watchtower ≅ Clovis > Wishstone ≅ Peace > Backstay. The rover's wheels uncovered one unusual soil (Paso Robles) that is the most S-rich material encountered. Clovis class rocks have compositions similar to Gusev plains soil but with higher Mg, Cl, and Br and lower Ca and Zn; Watchtower and Wishstone classes have high Al, Ti, and P and low Cr and Ni; Peace has high Mg and S and low Al, Na, and K; Backstay basalts have high Na and K comp…

Atmospheric ScienceGeochemistrySoil ScienceMineralogyPyroxeneAquatic Scienceengineering.materialOceanographyFeldsparGeochemistry and PetrologyEarth and Planetary Sciences (miscellaneous)Composition of MarsAllophaneEarth-Surface ProcessesWater Science and TechnologyBasaltgeographygeography.geographical_feature_categoryOlivineEcologyPaleontologyForestryVolcanic rockGeophysicsSpace and Planetary Sciencevisual_artengineeringvisual_art.visual_art_mediumIlmeniteGeologyJournal of Geophysical Research: Planets
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In situ and experimental evidence for acidic weathering of rocks and soils on Mars

2006

Experimental data for alteration of synthetic Martian basalts at pH=0-1 indicate that chemical fractionations at low pH are vastly different from those observed during terrestrial weathering. Rock analyses from Gusev crater are well described by the relationships apparent from low pH experimental alteration data. A model for rock surface alteration is developed which indicates that a leached alteration zone is present on rock surfaces at Gusev. This zone is not chemically fractionated to a large degree from the underlying rock interior, indicating that the rock surface alteration process has occurred at low fluid-to-rock ratio. The geochemistry of natural rock surfaces analyzed by APXS is c…

Atmospheric ScienceGeochemistrySoil ScienceMineralogyWeatheringAquatic Scienceengineering.materialOceanographychemistry.chemical_compoundGeochemistry and PetrologyEarth and Planetary Sciences (miscellaneous)Composition of MarsEarth-Surface ProcessesWater Science and TechnologyBasaltgeographyOlivinegeography.geographical_feature_categoryEcologyPaleontologySoil chemistryForestrySilicateVolcanic rockIgneous rockGeophysicschemistrySpace and Planetary ScienceengineeringGeologyJournal of Geophysical Research: Planets
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Mössbauer mineralogy of rock, soil, and dust at Gusev crater, Mars: Spirit's journey through weakly altered olivine basalt on the plains and pervasiv…

2006

The Moessbauer spectrometer on Spirit measured the oxidation state of Fe, identified Fe-bearing phases, and measured relative abundances of Fe among those phases for surface materials on the plains and in the Columbia Hills of Gusev crater. Eight Fe-bearing phases were identified: olivine, pyroxene, ilmenite, magnetite, nanophase ferric oxide (npOx), hematite, goethite, and a Fe(3+)-sulfate. Adirondack basaltic rocks on the plains are nearly unaltered (Fe(3+)/Fe(sub T) Px), and minor npOx and magnetite. Columbia Hills basaltic rocks are nearly unaltered (Peace and Backstay), moderately altered (WoolyPatch, Wishstone, and Keystone), and pervasively altered (e.g., Clovis, Uchben, Watchtower, …

Atmospheric ScienceGoethiteGeochemistrySoil ScienceMineralogyPyroxeneAquatic Scienceengineering.materialOceanographychemistry.chemical_compoundGeochemistry and PetrologyEarth and Planetary Sciences (miscellaneous)Composition of MarsEarth-Surface ProcessesWater Science and TechnologyMagnetiteBasaltOlivineEcologyPaleontologyForestryHematiteGeophysicschemistrySpace and Planetary Sciencevisual_artvisual_art.visual_art_mediumengineeringGeologyIlmeniteJournal of Geophysical Research: Planets
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Spirit Mars Rover Mission to the Columbia Hills, Gusev Crater: Mission overview and selected results from the Cumberland Ridge to Home Plate

2008

This paper summarizes the Spirit rover operations in the Columbia Hills of Gusev Crater from sols 513 to 1476 and provides an overview of selected findings that focus on synergistic use of the Athena Payload and comparisons to orbital data. Results include discovery of outcrops (Voltaire) on Husband Hill that are interpreted to be altered impact melt deposits that incorporated local materials during emplacement. Evidence for extensive volcanic activity and aqueous alteration in the Inner Basin is also detailed, including discovery and characterization of accretionary lapilli and formation of sulfate, silica, and hematite-rich deposits. Use of Spirit's data to understand the range of spectra…

Atmospheric Sciencegeographygeography.geographical_feature_categoryEcologyWater on MarsPaleontologySoil ScienceForestryMars Exploration ProgramAquatic ScienceOceanographyExploration of MarsCRISMAstrobiologyMars roverGeophysicsVolcanoImpact craterSpace and Planetary ScienceGeochemistry and PetrologyRidgeEarth and Planetary Sciences (miscellaneous)GeologyEarth-Surface ProcessesWater Science and TechnologyJournal of Geophysical Research
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