Search results for " MEGA"
showing 10 items of 64 documents
Reportage da Berlino megalopoli
2009
Editoriale
2020
Il numero 7 di AGATHÓN raccoglie saggi, studi, ricerche e progetti sul tema dal titolo ‘Dal Mega al Nano: la Complessità del Progetto Multiscalare’, tema indissolubilmente legato alla sempre maggiore richiesta di trans e multidisplinarietà del progetto. La capacità di effettuare ‘salti di scala’, di agire su scale diverse e di costruirne di nuove o di mutare il senso di quelle comunemente accettate è una pratica comune dell’approccio al progetto, e riguarda da sempre gli architetti, gli ingegneri, i designer e gli artisti, nei molteplici significati simbolici e reali della misura di un territorio, di una città, di un’architettura e di un oggetto. I concetti di scala e di misura sono indispe…
Prevention of chemotherapy-induced anemia and thrombocytopenia by constant administration of stem cell factor.
2011
Abstract Purpose: Chemotherapy-induced apoptosis of immature hematopoietic cells is a major cause of anemia and thrombocytopenia in cancer patients. Although hematopoietic growth factors such as erythropoietin and colony-stimulating factors cannot prevent the occurrence of drug-induced myelosuppression, stem cell factor (SCF) has been previously shown to protect immature erythroid and megakaryocytic cells in vitro from drug-induced apoptosis. However, the effect of SCF in vivo as a single myeloprotective agent has never been elucidated. Experimental Design: The ability of SCF to prevent the occurrence of chemotherapy-induced anemia and thrombocytopenia was tested in a mouse model of cisplat…
Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic proge…
2001
Stromal cell-derived factor-1alpha (SDF-1alpha) is a potent chemoattractant for hematopoietic progenitor cells (HPC), suggesting that it could play an important role during their migration within or to the bone marrow (BM). The integrin VLA-4 mediates HPC adhesion to BM stroma by interacting with CS-1/fibronectin and VCAM-1. It is required during hematopoiesis and homing of HPC to the BM. As HPC migration in response to SDF-1alpha might require dynamic regulation of integrin function, we investigated if SDF-1alpha could modulate VLA-4 function on BM CD34(hi) cells.CD34(hi) BM cells and hematopoietic cell lines were tested for the effect of SDF-1alpha on VLA-4-dependent adhesion to CS-1/fibr…
A Km-scale Cretaceous slope in western Sicily (Italy)
2017
Cretaceous slopes are well known from many regions of the world, since they are among the most prone depositional systems to host hydrocarbons. As far as Italy, in spite of fully described examples as the Majella and Gargano escarpments, detailed sedimentological and biostratigraphic studies from Sicily are not available, although the presence of slope carbonates of Cretaceous age in northwestern Sicily, is mentioned in several papers dealing with regional geology or geological mapping. The Cretaceous slope carbonates from this area, i.e. the San Vito Lo Capo Peninsula, belong to several thrust sheets of the Maghrebian chain. The stratigraphic setting in these tectonic units allows to recon…
Castillejo del Bonete (Terrinches, Ciudad Real): un complejo tumular prehistórico de la Cultura de las Motillas en el Alto Guadalquivir
2014
Situado en las estribaciones orientales de Sierra Morena, dentro de la cuenca hidrológica del Guadalquivir, Castillejo del Bonete es un gran complejo arquitectónico que consta de una cueva monumentalizada mediante estructuras varias, entre las que destacan varios corredores megalíticos y túmulos, todos ellos asociados a contextos funerarios y depósitos de ofrendas. El presente artículo se centra en la explicación detallada de los elementos que integran este complejo constructivo para posteriormente discutir el avance que supone para la investigación de la Prehistoria Reciente en La Mancha. Castillejo del Bonete tiene el potencial de convertirse en un yacimiento clave para la comprensión de …
Collar and root rot of olive trees caused by Phytophthora megasperma in Sicily
2019
Olive (Olea europea L.) is grown on about 154,000 ha in Sicily (southern Italy). In the summer of 1999, a few 3-year-old olive trees with decline symptoms were observed in a recently planted commercial orchard in the Enna province (Sicily). The trees were propagated on wild olive (O. europea L. var. sylvestris Brot.) rootstock. Aerial symptoms, consisting of leaf chlorosis, wilting, defoliation, and twig dieback followed in most cases by plant death, were associated with root rot and basal stem cankers. A Phytophthora sp. was consistently isolated from rotted rootlets and trunk cankers using the BNPRAH (benomyl, nystatin, pentachloronitrobenzene, rifampicin, ampicillin, and hymexazol) sele…
An automated image analysis methodology for classifying megakaryocytes in chronic myeloproliferative disorders
2008
This work describes an automatic method for discrimination in microphotographs between normal and pathological human megakaryocytes and between two kinds of disorders of these cells. A segmentation procedure has been developed, mainly based on mathematical morphology and wavelet transform, to isolate the cells. The features of each megakaryocyte (e.g. area, perimeter and tortuosity of the cell and its nucleus, and shape complexity via elliptic Fourier transform) are used by a regression tree procedure applied twice: the first time to find the set of normal megakaryocytes and the second to distinguish between the pathologies. The output of our classifier has been compared to the interpretati…
Improving the Seismic Response of Tall Buildings: From Diagrid to Megastructures and Mega-Subcontrol Systems
2022
Background: Diagrid structures, widely used for the tall buildings of the third millennium, are characterized by a very effective behaviour in the elastic field due to the grid triangulation. In particular, under horizontal actions, axial forces and deformations mainly arise in the structural members of the diagrid, thus resulting in the reduction of the shear lag effect and racking deformations. The response to incremental horizontal actions beyond the plastic threshold, however, shows a poor plastic redistribution capacity, with consequent low values of global ductility, in spite of a significant design overstrength. Objective: In this paper, it is proposed to exploit the high elastic ef…
Old World Megadroughts and Pluvials During the Common Era
2015
An atlas of megadroughts in Europe and in the Mediterranean Basin during the Common Era provides insights into climate variability.