Search results for " MIC"
showing 10 items of 11429 documents
Nuevas faunas de micromamíferos del Terciario continental de la Depresión Intermedia (provincia de Cuenca, España centro-oriental)
1986
In this paper the fossil content of nine new micromammal bearing localities and that of 15 levels in a borehole from the Loranca Basin (eastern Tague Basin, Prov. of Cuenca) is described. The age ranges from early Arvernian (Late Oligocene) to Turolian (Late Miocene). 47 rodent and lagomorph taxons have been found which are arranged in 8 biostratigraphic units. The Loranca-2 borehole contains 15 fossiliferous levels covering the Upper Oligocene/Lower Miocene. These additional data complete the faunal sequence published by Díaz & López(1919). The stratigraphic framework of the basin needs a revision because of the new faunal data.<br><br>Se presenta una serie de 9 nuevos yaci…
Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(
2019
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparti…
Le potenzialità delle colture in vitro nella conservazione e diffusione di germoplasma di Morus spp.
2009
Apple, Ibm and Microsoft in a war of signs
2007
The aim of my paper is exploring how image contributes on building the brand identity of specific organisations and how the meaning of the image can be resignified by the action of the players in a specific market. In particular, I will focus on the competition between three brands, Ibm, Apple, Microsoft. on the information technology market. My work is looking forward to be a continuation of the essay “Le vie du Logo” published in “Identités visuelles” by Jean Marie Floch about the visual competition between Apple and Ibm. I will use the tools of sociosemiotics, plastic and figurative analysis, screening more than 20 years of competition starting from 1984, the year in which the analysis o…
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
2015
International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…
Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis
2022
There has been a recent, unprecedented interest in the role of gut microbiota in host health and disease. Technological advances have dramatically expanded our knowledge of the gut microbiome. Increasing evidence has indicated a strong link between gut microbiota and the development of cardiovascular diseases (CVD). In the present article, we discuss the contribution of gut microbiota in the development and progression of CVD. We further discuss how the gut microbiome may differ between the sexes and how it may be influenced by sex hormones. We put forward that regulation of microbial composition and function by sex might lead to sex-biased disease susceptibility, thereby offering a mechani…
Genetic variability of the blue and red shrimp Aristeus antennatus in the Western Mediterranean Sea inferred by DNA microsatellite loci
2012
Genetic variation at eight microsatellite loci was studied in nine populations of the blue and red shrimp Aristeus antennatus to investigate whether distinct stocks are present in the Western Mediterranean Sea. A high level of gene flow and no evidence of genetic partitioning were discovered. No significant variation was found (FST = 0.00673, P-value = 0.067) even when shrimps from exploited and those from deep-water unexploited grounds were compared. No evidence of reduction or expansion of population size in the recent past was found, as indicated by the bottleneck and interlocus g-tests. Our results are consistent with previous studies using mitochondrial gene methods and allozymes, indi…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
Wpływ dodatku bioaktywnych mikrocząstek srebra na właściwości użytkowe tynków mineralnych
2013
Aktywność mikroorganizmów, a przede wszystkim bakterii i grzybów w istotny sposób wpływa na swoiste cechy i wartość użytkową materiałów budowlanych. Jest to rodzaj korozji biologicznej, stanowiącej szczególny przypadek korozji chemicznej, która powoduje obniżenie lub utratę właściwości użytkowych materiału. Oprócz korozji biologicznej, grzyby mogą również stwarzać zagrożenie dla zdrowia użytkowników zasiedlonych obiektów. Ich toksyczne oddziaływanie na zdrowie ludzi i zwierząt uważa się za znacznie groźniejsze w skutkach od biokorozji materiałów. Stosowane obecnie środki biobójcze w postaci biocydów i nanocząstek srebra również mogą stanowić zagrożenie. W prezentowanej pracy przedstawiono w…