Search results for " MIR"
showing 10 items of 304 documents
Transconductance Converters Based on Current Mirrors Applied to pH Measurement Using ISFET Sensors
2009
New transconductance circuits (V/I converters) are designed based on current mirrors and operational amplifiers. Their input/output characteristics and the influence of DC parameters are obtained. Experimental results were performed, comparing them with the simulated results. An electronic instrumentation circuit is designed based on one of the transconductance converters analyzed. The purpose of this circuit was to condition the response of an ion-sensitive field-effect transistor (ISFET) to measure pH. In the proposed application, the V/I converter presented provides the stability and accuracy of the ISFET operating point, making an easy characterization procedure and the design of multic…
Electrical connections and driving electronics for piezo-actuated x-ray thin glass optics
2016
Use of thin glass modular optics is a technology currently under study to build light, low cost, large area X-ray telescopes for high energy astrophysics space missions. The angular resolution of such telescopes is limited by local deviations from the ideal shape of the mirrors. One possible strategy to improve it consists in actively correcting the mirror profile by gluing thin ceramic piezo-electric actuators on the back of the glasses. A large number of actuators, however, requires several electrical connections to drive them with the different needed voltages. We have developed a process for depositing conductive paths directly on the back of non-planar thin foil mirrors by means of a p…
Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network
2021
Climate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of response of melon to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or triple …
Analysis of MSCs' secretome and EVs cargo: Evaluation of functions and applications
2022
Mesenchymal stem cells (MSCs) can exert different functions and can be used in several medical fields. In the last years, MSC properties have been attributed to their secreted factors such as soluble proteins, cytokines and growth factors. Moreover, a key role is played by the extracellular vesicles (EVs) which lead a heterogeneous cargo of proteins, lipids and small and long non-coding RNAs that interfere with the pathways of the recipient cells. Due to the safeness and easiness in obtaining the secretome, its use is becoming a turning point for the application in physiological and pathological fields. This review summarizes the most recent studies on the use of MSCs secretome, focusing on…
MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells
2022
Abstract Chronic lymphocytic leukemia (CLL) cells express the interleukin-23 receptor (IL-23R) chain, but the expression of the complementary IL-12Rβ1 chain requires cell stimulation via surface CD40 molecules (and not via the B-cell receptor [BCR]). This stimulation induces the expression of a heterodimeric functional IL-23R complex and the secretion of IL-23, initiating an autocrine loop that drives leukemic cell expansion. Based on the observation in 224 untreated Binet stage A patients that the cases with the lowest miR-146b-5p concentrations had the shortest time to first treatment (TTFT), we hypothesized that miR-146b-5p could negatively regulate IL-12Rβ1 side chain expression and clo…
Mobilisation of plasmid-mediated blaVEB-1 gene cassette into distinct genomic islands of Proteus mirabilis after ceftazidime exposure
2021
ABSTRACT Objectives We sought to integrate a VEB-1-encoding gene cassette into the integron of the MDR region of genomic islands (GIs) harboured by Proteus mirabilis strains after antibiotic exposure. Methods An IncP1 plasmid from Achromobacter xylosoxidans carrying the cassette array dfrA14–blaVEB-1–aadB was introduced by conjugation into five strains of P. mirabilis: PmBRI, PmABB, PmSCO and Pm2CHAMA harbouring Salmonella GI 1 and PmESC harbouring Proteus GI 1. Circular intermediates of the cassettes were amplified by PCR. blaVEB-harbouring P. mirabilis were exposed to increasing concentrations of ceftazidime each day. Presence of blaVEB-1 in the GI was assessed by PCR. The complete MDR re…
An updated checklist of chondrichthyans of Calabria (Central Mediterranean, southern Italy), with emphasis on rare species
2020
In this contribution the checklist of chondrichthyans of Calabria (Central Mediterranean, southern Italy) is reported. Data presented is derived from twenty years of opportunistic and active surveys from 2000 to 2020. A total of 55 species of chondrichthyans is present in Calabrian seas: 33 sharks, 20 rays, and 2 chimaeras. These species represent approximately 62% of the total reported for the Mediterranean. Approximately 71% of Calabrian species have been reported in the Tyrrhenian Sea, 49% in the Ionian Sea, and 33% in the Strait of Messina. According to IUCN criteria, new records of Endangered and Critically Endangered species (i.e., Carcahrodon carcharias [Linnaeus, 1758], Lamna nasus …
New European Discovery of Splachnum pensylvanicum (Bryophyta, Splachnaceae) in Lithuania, with Taxonomic Notes and a Review of Its World Distribution
2021
Splachnum pensylvanicum (Brid.) Grout ex H.A.Crum is recorded for the first time in Lithuania and it is its fourth discovery at a third locality in Europe. It was found for the first time in 2000 in Kamanos mire, the largest peatland complex in the northern part of this East Baltic country. Targeted investigations at this site in 2017 resulted in the discovery of 14 populations and it is apparently the largest and most abundant locality of the species in Europe. Splachnum pensylvanicum is briefly described and illustrated along with some taxonomic notes and a detailed description of its habitat requirements. The global geographical distribution of S. pensylvanicum is reviewed and mapped. It…
Gozos al glorioso San Nicolas el Magno, Arzobispo de Mira
1761
El full orlat Grav. xil. enmarcat del sant, flanquejat per gerros amb flors El text del goig a tres col. separades per bandes
Gozos al glorioso San Nicolas el Magno, Arzobispo de Mira
1750
El full orlat Grav. xil. enmarcat del sant, flanquejat per gerros amb flors El text del goig a tres col. separades per bandes