Search results for " MIR"

d-Alanyl-d-Alanine Carboxypeptidase in the Bacterial Form and L-Form of Proteus mirabilis

1975

Membranes of the bacterial form and the stable and unstable L-forms of Proteus mirabilis contain LD and DD-carboxypeptidase. The DD-carboxypeptidase is inhibited non-competitively by penicillin G. The enzyme of the bacterial form is highly penicillin-sensitive (Ki - 4 X 10(-9) M penicillin G). Inhibition is only partly reversible by treatment with penicillinase or by dialysis against buffer. In contrast, the DD-carboxypeptidase of the unstable L-form, grown in the presence of penicillin, is 175-fold less penicillin-sensitive (Ki = 7 X 10(7) M penicillin G). Inhibition is completely reversed by penicillinase or dialysis. After inhibition by penicillin and subsequent reactivation the penicill…

A loop involving NRF2, miR‐29b‐1‐5p and AKT, regulates cell fate of MDA‐MB‐231 triple‐negative breast cancer cells

2019

The present study shows that nuclear factor erythroid 2-related factor 2 (NRF2) and miR-29b-1-5p are two opposite forces which could regulate the fate of MDA-MB-231 cells, the most studied triple-negative breast cancer (TNBC) cell line. We show that NRF2 activation stimulates cell growth and markedly reduces reactive oxygen species (ROS) generation, whereas miR-29b-1-5p overexpression increases ROS generation and reduces cell proliferation. Moreover, NRF2 downregulates miR-29b-1-5p expression, whereas miR-29b-1-5p overexpression decreases p-AKT and p-NRF2. Furthermore, miR-29b-1-5p overexpression induces both inhibition of DNA N-methyltransferases (DNMT1, DNMT3A, and DNMT3B) expression and …

Two new Salmonella genomic islands 1 from Proteus mirabilis and description of blaCTX-M-15 on a variant (SGI1-K7)

2018

Objectives To characterize the structure of Salmonella genomic islands 1 (SGI1s) from two clinical Proteus mirabilis isolates: one producing an ESBL and the other a penicillinase. Methods WGS completed by PCR and Sanger sequencing was performed to determine sequences of SGI1s from Pm2CHAMA and Pm37THOMI strains. Results Two new variants of SGI1 named SGI1-Pm2CHAMA (53.6 kb) and SGI1-K7 (55.1 kb) were identified. The backbone of SGI1-Pm2CHAMA shared 99.9% identity with that of SGI1. Its MDR region (26.3 kb) harboured two class 1 integrons (an In2-type integron and an In4-type integron) containing in particular a qacH cassette (encoding a quaternary ammonium compound efflux pump). These two i…

Coordinated Interpersonal Behaviour in Collective Dance Improvisation: The Aesthetics of Kinaesthetic Togetherness

2018

International audience; Collective dance improvisation (e.g., traditional and social dancing, contact improvisation) is a participatory, relational and embodied art form which eschews standard concepts in aesthetics. We present our ongoing research into the mechanisms underlying the lived experience of "togetherness" associated with such practices. Togetherness in collective dance improvisation is kinaesthetic (based on movement and its perception), and so can be simultaneously addressed from the perspective of the performers and the spectators, and be measured. We utilise these multiple levels of description: the first-person, phenomenological level of personal experiences, the third-perso…

Mašīnmācīšanās pielietojums elektrības mirkļa cenas paredzēšanai

2016

Darba mērķis ir izpētīt mašīnmācīšanās pielietojumu konkrētas problēmas risināšanai. Izvēlētā pētāmā problēma ir elektrības cenas paredzēšana, izmantojot dažādus pieejamos faktorus par noteiktu laika periodu. Darbs tika izstrādāts sadarbojoties ar Viktoriju Bobinaiti, kura izstrādāja savu pētījumu „Modelling Electricity Price Expectations in a Day-Ahead Electricity Market”, no šī pētījuma tika iegūti atbilstošie dati. Darbā tika izveidota datorprogramma, kas pielieto specifisku mašīnmācīšanās veidu – neironu tīklus. Izveidota datorprogramma spēj parametrizēti izveidot neironu tīklus, ļaujot pielāgot gan apmācīšanas procesu, gan mainīt neironu tīkla struktūras parametrus, gan filtrēt pieejam…

Le funzioni delle reti mirabili encefaliche

2009

I numerosi spiaggiamenti di delfini e balenottere potrebbero collegarsi a fenomeni d’ipossia cerebrale causata dalla vasodilatazione in vaste aree delle reti mirabili encefaliche. Questa vasodilatazione riduce il controllo su di CBF e MAP e non è compensata da un apporto aggiuntivo diretto di sangue come avviene per il Gatto, ruminanti, Giraffa ed altri mammiferi provvisti di reti mirabili encefaliche. La pressione intracranica sarebbe l’effettiva pressione di flusso della circolazione cerebrale. Studi su altri organi hanno invece trovato che l’effettiva pressione di flusso è data dalla pressione critica di chiusura (storno), localizzata nelle arteriole. Weyland A. et all.(2000), affermano …

Carta de José Vidal-Beneyto a Fernando Álvarez de Miranda

2000

Gozos a la devotissima imagen de nuestra Señora del Milagro : Venerada en el ... Convento de Religiosas Franciscas, de la Primitiva Regla de Santa Cl…

El full orlat Grav. xil. enmarcat de la imatge, flanquejat per gerros amb flors Text del goig a tres col. separades per filets

Virgen con gran propiedad del Milagro Intitulada; sed nuestra fiel Abogada en qualquier necessidad.

Com a tít. la primera estrofa. El full orlat. Grav. xil. enmarcat de la "Imn. de Nª. Sª. del Milº.", flanquejat per gerros amb flors. Text del goig a dues col. separades per banda.

Gozos a la [imagen?] de nuestra Señora del Milagro, venerada en el Convento de Religiosas de la Madre Santa Clara de la Villa de Cocentaina, y en las…

El full orlat. Grav. xil. enmarcat de "Nª. Sª. del Milagro", flanquejat per gerros amb flors. Text del goig a tres col. separades per filets.