Search results for " MMP"

showing 10 items of 46 documents

Immunohistochemical expression of apoptotic factors, cytokeratins, and metalloproteinase-9 in periapical and epithelialized gingival lesions

2012

Bellmann K, 2010, CELL STRESS CHAPERON, V15, P101, DOI 10.1007-s12192-009-0126-9; Cappello Francesco, 2011, Front Biosci (Schol Ed), V3, P341, DOI 10.2741-s155; Cappello F, 2006, CANCER, V107, P2417, DOI 10.1002-cncr.22265; Cappello F, 2002, EUR J HISTOCHEM, V46, P199; Carneiro E, 2009, ORAL SURG ORAL MED O, V107, P127, DOI 10.1016-j.tripleo.2008.07.030; Chandra D, 2007, J BIOL CHEM, V282, P31289, DOI 10.1074-jbc.M702777200; Fujita Y, 2011, ODONTOLOGY, V100, P215; Garcia Celia Carrillo, 2007, Med Oral Patol Oral Cir Bucal, V12, pE585; Garcia CC, 2009, ORAL SURG ORAL MED O, V107, pE43, DOI 10.1016-j.tripleo.2008.12.002; Gregory CD, 2011, J PATHOL, V223, P177, DOI 10.1002-path.2792; Gupta S, …

Histologybusiness.industryCaspase 3GingivaApoptosisGeneral MedicineMolecular biologyImmunohistochemistryCaspase 9EpitheliumPathology and Forensic MedicineCell stressMatrix Metalloproteinase 9cytokeratins MMP-9 caspase-3 caspase-9 perapical lesions epithelial gingival lesions apoptosisIHC PCNA TUNELProliferating Cell Nuclear AntigenMedicineHumansKeratinsbusinessApoptosis Regulatory ProteinsPeriapical Granuloma
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Another function of Hsp70 in mesoangioblast stem cells

2010

In recent years, it has been demonstrated that Hsp70 is released in the extracellular space under normal cell culture conditions, and this release is mediated through exosomes. We have demonstrated that A6 cells, a clone of mouse mesoangioblasts, produce and release in the extracellular space membrane vesicles, independently of culture growth conditions. These vesicles contains both structural proteins and biological active molecules, such as FGF-2 and the metalloproteinases MMP 2 and 9. We have also demonstrated that A6 vesicles contain HspP70 and its release is highly regulated. Some of the intracellular Hsp70 is localized on lipid rafts and its concentration in insoluble fraction increas…

Hsp70 MMP2/9
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Hsp70 level regulates MMP2 expression in mesoangioblast stemj cells

2013

Hsp70 mesoangioblasts stem cells MMP2
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Role of matrix metalloproteases 2, 9 (MMP-2, -9), orphanin FQ and others peptides in vascular tone of human umbilical cord at term

2008

Umbilical cord is the structure that connects the fetus to the placenta. Umbilical cord at term is made of three vessels surrounded by the Wharton’s jelly, a mucous connective tissue rich in glycosaminoglycans, proteoglycans and different types of collagens and other microfibrils, which are responsible for its elasticity and its mechanical properties.Umbilical cord seems to lack any capillaries or lymphatics and umbilical vessels are unique in lacking any innervation; thus endothelial cells may play the major role in the local control of the blood flow. Objectives. In this paper we investigated in human umbilical cord at term the expression of some peptides involved in the regulation of the…

Human umbilical cord MMP-2 MMP-9 Orphanin Oxytocin ANF eNOS iNOS.
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Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals

2012

Abstract: The aim of the study was to assess the involvement of apoptotic factors, cytokeratins and metalloproteinase- 9 in the histogenesis of both Epithelialized Gingival Lesions (EGL) and Periapical Lesions (PAL). 55 consecutive patients, 30 with PAL and 25 with EGL, were selected for the study after clinical and radiological examinations. The PAL patients had severe periapical lesions and tooth decay with exposure of the pulp chamber. All PAL and EGL biopsies were surgically extracted, fixed in 10% buffered formalin, and processed for routine light microscopy. Ten biopsies of each category were processed for immunohistochemistry (IHC). Serial paraffin sections were stained by IHC with a…

LeptinKey words: cytokeratins MMP-9 caspase-3 caspase-9 perapical lesions epithelial gingival lesions apoptosis IHC PCNA TUNELSettore BIO/17 - Istologiamedicine.medical_specialtyHistologySubmandibular Glandcytokeratins MMP-9 caspase-3 caspase-9 perapical lesions epithelial gingival lesions apoptosis IHC PCNA TUNEL [Key words]major salivary glands orphanin FQ nociception orexin leptin IHC rat sheep cowBiologySalivary GlandsPathology and Forensic MedicineOrexin-ASublingual Glandstomatognathic systemInternal medicineMajor Salivary GlandOrexigenicmedicineEndocrine systemAnimalsParotid GlandMammalsOrexinsSheepSalivary glandNeuropeptidesConnective tissue stromaIntracellular Signaling Peptides and ProteinsGeneral MedicineImmunohistochemistryEpitheliumOrexinRatsmedicine.anatomical_structureEndocrinologyOpioid PeptidesCattlemedicine.drug
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Manganese overload affects p38 MAPK phosphorylation and metalloproteinase activity during sea urchin embryonic development.

2014

Abstract In the marine environment, manganese represents a potential emerging contaminant, resulting from an increased production of manganese-containing compounds. In earlier reports we found that the exposure of Paracentrotus lividus sea urchin embryos to manganese produced phenotypes with no skeleton. In addition, manganese interfered with calcium uptake, perturbed extracellular signal-regulated kinase (ERK) signaling, affected the expression of skeletogenic genes, and caused an increase of the hsc70 and hsc60 protein levels. Here, we extended our studies focusing on the temporal activation of the p38 mitogen-activated protein kinase (p38 MAPK) and the proteolytic activity of metalloprot…

MAPK/ERK pathwayEmbryo NonmammalianAquatic ScienceBiologyMatrix metalloproteinaseOceanographyp38 Mitogen-Activated Protein KinasesParacentrotus lividusbiology.animalECM ERK Embryo-toxicity Immunoblotting MAPK MMPs Marine organisms' calcification Mn SDS-PAGE Zymography extracellular matrix extracellular signal-regulated kinase manganese metalloproteinases mitogen-activated protein kinase p38 MAPK sodium dodecyl sulfate-polyacrylamide gel electrophoresisAnimalsSettore BIO/06 - Anatomia Comparata E CitologiaPhosphorylationProtein kinase ASea urchinManganeseKinaseGeneral Medicinebiology.organism_classificationPollutionMatrix MetalloproteinasesBiochemistryMitogen-activated protein kinasebiology.proteinParacentrotusPhosphorylationWater Pollutants ChemicalMarine environmental research
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MMP-2, MMP-9 and MMP-14 in breast cancer: clinicopathological correlations.

2009

MMP2 MMP9 MMP14 MMPs Breast cancerSettore BIO/06 - Anatomia Comparata E Citologia
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Nandrolone decanoate interferes with testosterone biosynthesis altering blood-testis barrier components

2017

Abstract The aim of this study was to investigate whether nandrolone decanoate (ND) use affects testosterone production and testicular morphology in a model of trained and sedentary mice. A group of mice underwent endurance training while another set led a sedentary lifestyle and were freely mobile within cages. All experimental groups were treated with either ND or peanut oil at different doses for 6 weeks. Testosterone serum levels were measured via liquid chromatography–mass spectrometry. Western blot analysis and quantitative real‐time PCR were utilized to determine gene and protein expression levels of the primary enzymes implicated in testosterone biosynthesis and gene expression leve…

Male0301 basic medicinemedicine.medical_specialtyNandrolone decanoateStimulationEndogenyMUC1BiologyMale infertilityMice03 medical and health sciencesAnabolic AgentsWestern blotPhysical Conditioning AnimalInternal medicineTestisGene expressionmedicineAnimalsNandroloneBlood-testis barrier; MMP-2; MMP-9; MUC1; Nandrolone decanoate; Testosterone; TJP1; Molecular Medicine; Cell Biologyblood–testis barrierInducerTestosteroneTJP1TestosteroneBlood-testis barrierBlood–testis barrierMMP‐9medicine.diagnostic_testMMP-2Mucin-1Tissue Inhibitor of MetalloproteinasesOriginal ArticlesCell Biologymedicine.diseaseProtein Transport030104 developmental biologyEndocrinologyGene Expression RegulationMatrix Metalloproteinase 9Zonula Occludens-1 ProteinMatrix Metalloproteinase 2Molecular MedicineOriginal ArticleMMP‐2Sedentary BehaviorMMP-9Signal Transduction
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Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative…

2016

Abstract Background Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications. Materials and methods For this purpose, 90 patients and two control groups were genotyped for rs3918242, rs243865, and r…

MalePathologyHeart Valve DiseasesDisease030204 cardiovascular system & hematologyMatrix metalloproteinasers3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Aged; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Mitral Valve; Prospective Studies; Risk Factors; Polymorphism Single Nucleotide0403 veterinary scienceCohort Studies0302 clinical mediciners2285053 MMP-2 and MMP-9 gene SNPsRisk FactorsGenotypeManagement and outcomeNatriuretic peptideProspective StudiesProspective cohort studyMVDSMetalloproteinaseDegenerative forms of mitral valve diseases04 agricultural and veterinary sciencesGeneral MedicineSingle NucleotideMiddle AgedMetalloproteinasesPathophysiologyMatrix Metalloproteinase 9Matrix Metalloproteinase 2Mitral ValveFemalers3918242Cardiology and Cardiovascular MedicineDegenerative forms of mitral valve diseasemedicine.medical_specialtyGenotype040301 veterinary sciencesmedicine.drug_class2734Single-nucleotide polymorphismDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Cardiology and Cardiovascular Medicine; 2734Polymorphism Single NucleotidePathology and Forensic Medicine03 medical and health sciencesInternal medicinemedicineHumansGenetic Predisposition to Diseasers243865PolymorphismAgedbusiness.industrySettore MED/23 - Chirurgia Cardiacabusiness
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Expression of MMP-2 and MMP-9 in odontogenic myxoma in a child: report of a clinical case

2011

Odontogenic myxoma (OM) is a benign, locally invasive, non-metastasizing neoplasm of the jaw bones. Despite the benign nature of these lesions, there is a high rate of recurrence and the current recommended therapy, depending on the size and behaviour of the lesion, can vary from curettage with peripheral ostectomy, segmental resection up to radical resections for more aggressive lesions. OM is a rare tumour which occurs predominantly in the third decade of life and it is rare in children. Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases responsible for the degradation and remodelling of extracellular matrix, they are known to be involved in the progression and …

MaleSettore BIO/17 - IstologiaPathologymedicine.medical_specialtymedicine.medical_treatmentOdontogenic TumorsBiologyInferior alveolar nerveMatrix metalloproteinaseOdontogenic myxomaLesionExtracellular matrixSettore MED/28 - Malattie OdontostomatologichemedicineHumansChildGeneral DentistryDNA PrimersBase SequenceReverse Transcriptase Polymerase Chain Reactionmedicine.diseaseCurettageMatrix Metalloproteinase 9ImmunohistochemistryMatrix Metalloproteinase 2medicine.symptomSegmental resectionMyxomaOdontogenic myxoma Child MMP-2 MMP-9 it
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