Search results for " MMP"

Gli aneurismi dell'aorta addominale

2009

Not available

Expression and localization of matrix metalloproteinases MMPs in human umbilical cord

2009

Expression of remodelling enzymes (MMP-2, MMP-8, MMP-9) in mixed tumors of salivary gland

2009

Role of Matrix Metalloproteinases 2,9 (MMP-2,-9), Orphanin FQ and Others Peptides in Vascular Tone of Human Umbilical Cord at Term

2008

Umbilical cord is the structure that connects the fetus to the placenta. Umbilical cord at term is made of three vessels surrounded by the Wharton's Jelly, a mocous connective tissue rich in glycosaminoglycans, proteoglycans and different types of collagens and other microfibrils, which are responsible for its elasticity and its mechanical properties. Umbilical cord seems to lack any capillaries or lymphatics and umbilical vessels are unique in lacking any innervation of the vascular tone, and the expression of some enzymes responsible for the remodelling of the extracellular matrix. Trough immunihistochemistry we investigated the expression of matrix metallo-peptidase 2 and 9 (MMP-2, MMP-9…

Expression of Remodelling Enzymes (MMP-2, MMP-9) in Normal and Pathological Oral Mucosa Samples

2008

Introduction. The oral cavity contains many structures compressed in a small area. It is exposed to chronic or recurrent, physical and chemical trauma leading to mucosal reactions (e.g. hyperplasia, dysplasia and tumors). For a long time, our group has been studying the expression of some metalloproteinases (MMP-2, MMP-9) in healthy and pathological human oral mucosa through immunohistochemistry and RT-PCR to investigate the entity of the remodelling process in the different cases. Matherials and Methods. In this paper we investigate a sample of normal oral mucosa and four pathological samples (mucocele, fibroma, dysplasia and carcinoma). We identified the localization of MMP-2 and MMP-9 th…

Matrix metalloproteinase-2 matrix metalloproteinase-9 and inducible nitric oxide synthase in oral leukoplakia: Immunohistochemistry and RT-PCR analys…

2008

Oral leukoplakia is the most common and potentially malignant disorder of the oral mucosa. The definition of leukoplakia given by the World Health Organization is "a white plaque that cannot be characterized either from a clinical or from a histopathological point of view", thus the diagnosis of leukoplakia is based on the exclusion of other lesions of the oral mucosa. We believe it is necessary to identify molecular and immunohistochemical parameters that can contribute to discriminating between the different leukoplakia clinical subtypes coded by the epidemiology. In the present work we show the preliminary results of this research project. We investigated the expression of matrix metallo…

Immunohistochemical expression of iNOS and matrix metalloproteinases MMP-2 and MMP-9 in aortic aneurysms

2007

Aortic aneurysms (AA) is a degenerative vascular disease characterized by localized dilatation of the aortic wall as a result of altered matrix composition (elastin and collagen degradation). Howewer the pathogenesis of the changes is elusive and unclear. Some experimental evidences suggest that iNOS (who synthesize a large amount of NO in inflammatory processes) and the metalloproteinases (MMP) are implicated in the pathogenesis of AA but the relationship between NO and MMP to aneurismal disease is currently unknown. The aim of this study is to investigate the immunohistochemical expression of iNOS and MMP2 and MMP9 in human aneurysmal tissues.

Robust and Model Predictive Control applied to DC/DC converters and Shunt Active Filters

Al giorno d'oggi, la domanda di energia elettrica incrementa giorno per giorno. La gente spesso la usa con superficialità sottovalutando quanto essa sia preziosa. Fino a qualche decennio fa, la generazione di energia elettrica era centralizzata e dipendeva dallo sfruttamento delle risorse fossili. La limitatezza delle fonti fossili, insieme agli effetti ambientali del loro sfruttamento, hanno portato la ricerca a trovare vettori energetici alternativi poco inquinanti e facilmente reperibili. Lo sviluppo e la diffusione delle fonti energetiche rinnovabili hanno sancito la fine di una rete elettrica centralizzata a favore di una nuova idea di rete elettrica di tipo distribuita che permette di…

Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers.

2015

Venous leg ulcers are common in subjects with chronic venous insufficiency. The increased intraluminal pressure causes alteration of the skin microcirculation, leukocyte activation and release of proteolytic enzymes leading to ulceration. An impaired expression and activity of matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) might influence extracellular matrix degradation and deposition in chronic venous ulcers with the failure of the healing process. Our aim was to evaluate plasma concentration of gelatinases (MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in subjects with venous leg ulcers before and after the compression therapy. We enrolled 36 subjects (12 …

Vanadium perturbs the fertilization outcome and the metalloproteinase activity in sea urchin embryos

2021

Metal toxicology represents a current major topic due to the disper- sion of these elements in the environment. Metals are released from both natural sources and industrial activities. Some of them have also a clinical interest due to their application as metallodrugs (i.e., Pt, Cu, Au, Ru, and Y) or in medical diagnosis (Gd).1,2 Recently, V derivatives are considered as potential therapeutic factors in some diseases (e.g., obesity, diabetes, cancer, neurodegenerative and heart disorders). As a consequence, pharmaceutical residues could repre- sent emerging pollutants of aquatic environments, as wastewater treatment plants do not sufficiently remove these compounds3. Embryonic models repres…