Search results for " MS"

The Interconnecting Hairpin Extension "Arm": An Essential Allosteric Element of Phytochrome Activity

2023

In red-light sensing phytochromes, isomerization of the bilin chromophore triggers structural and dynamic changes across multiple domains, ultimately leading to control of the output module (OPM) activity. In between, a hairpin structure, "arm", extends from an interconnecting domain to the chromophore region. Here, by removing this protein segment in a bacteriophytochrome from Deinococcus radiodurans (DrBphP), we show that the arm is crucial for signal transduction. Crystallographic, spectroscopic, and biochemical data indicate that this variant maintains the properties of DrBphP in the resting state. Spectroscopic data also reveal that the armless systems maintain the ability to respond t…

Does reviewing experience reduce disagreement in proposals evaluation? Insights from Marie Skłodowska-Curie and COST Actions

2021

Abstract We have limited understanding of why reviewers tend to strongly disagree when scoring the same research proposal. Thus far, research that explored disagreement has focused on the characteristics of the proposal or the applicants, while ignoring the characteristics of the reviewers themselves. This article aims to address this gap by exploring which reviewer characteristics most affect disagreement among reviewers. We present hypotheses regarding the effect of a reviewer’s level of experience in evaluating research proposals for a specific granting scheme, that is, scheme reviewing experience. We test our hypotheses by studying two of the most important research funding programmes i…

Quantitative EEG differentiates multiple sclerosis with and without cognitive impairment from healthy controls at the beginning of the disease: preli…

2018

Background and aims: The present study aims to assess possible qEEG differences between newly diagnosed multiple sclerosis (MS) patients with or without cognitive impairment (CI). Methods: We enrolled 22 patients (18-55-years-old) treated with first-line drugs for <6 months, and 11 healthy controls. All subjects underwent neuropsychological assessment including BICAMS and BDI. EEG recordings were performed during a cognitive task (computerised “SDMT” subtest of BICAMS) and at rest. Based on neuropsychological assessment, patients were considered as affected (MSCI group) or not (MS group) by cognitive impairment. We analysed data comparing MSCI patients matched by sex, age (±5years) and e…

Les plate-formes technologiques du réseau des MSH

2018

National audience

Influence of a Thiolate Chemical Layer on GaAs (100) Biofunctionalization: An Original Approach Coupling Atomic Force Microscopy and Mass Spectrometr…

2013

International audience; Widely used in microelectronics and optoelectronics; Gallium Arsenide (GaAs) is a III-V crystal with several interesting properties for microsystem and biosensor applications. Among these; its piezoelectric properties and the ability to directly biofunctionalize the bare surface, offer an opportunity to combine a highly sensitive transducer with a specific bio-interface; which are the two essential parts of a biosensor. To optimize the biorecognition part; it is necessary to control protein coverage and the binding affinity of the protein layer on the GaAs surface. In this paper; we investigate the potential of a specific chemical interface composed of thiolate molec…

Archivio per l’Antropologia e la Etnologia

2017

This paper describes the study of human fibrocartilaginous entheses in a multiple indigenous sicanian Sicilian burial dated between VI and V century BC. The tomb, a cave burial, was altered by grave robbers. From the collected osteologic material it was possible to perform the sorting method and to extrapolate the NMI. The research was focused on the scoring and on the analysis of the Entheseal Changes (EC) of the long bones of upper limb and calcaneus; to extrapolate likely patterns of muscle activity according to the approach of the MSM applied in literature we have utilized the Coimbra Method. This method is a new record method who intends to replace Hawkey and Merbs already-established …

Laser fluence, repetition rate and pulse duration effects on paint ablation

2006

Abstract The efficiency (mm3/(J pulse)) of laser ablation of paint was investigated with nanosecond pulsed Nd:YAG lasers (λ = 532 nm) as a function of the following laser beam parameters: pulse repetition rate (1–10,000 Hz), laser fluence (0.1–5 J/cm2) and pulse duration (5 ns and 100 ns). In our study, the best ablation efficiency (η ≅ 0.3 mm3/J) was obtained with the highest repetition rate (10 kHz) at the fluence F = 1.5 J/cm2. This ablation efficiency can be associated with heat accumulation at high repetition rate, which leads to the ablation threshold decrease. Despite the low thermal diffusivity and the low optical absorption of the paint (thermal confinement regime), the ablation th…

Transient behaviour of a MSF desalination unit: modelling and experiments

2008

Legionella pneumophila izplatība un sekvenču tipu daudzveidība Latvijas viesnīcu ūdensapgādes sistēmās

2018

Legionella pneumophila ir nosacīti patogēna, dabiskās un mākslīgi radītās saldūdens ūdenskrātuvēs sastopama baktērija, kas spēj izraisīt infekcijas slimību – legionelozi. Lai noskaidrotu L. pneumophila izplatību Latvijā, no 40 viesnīcu ūdensapgādes sistēmām noņemti 240 karstā ūdens paraugi un testēti uz L. pneumophila klātbūtni. No pētījumā iesaistītajām viesnīcām 25 (65 %) viesnīcās konstatēts vismaz viens Legionella pozitīvs paraugs. Maksimālais L. pneumophila koloniju veidojošo vienību skaits vienā paraugā bija 1,1 x 104 kvv/l. Ar MALDI-TOF MS apstiprināti 99 L. pneumophila un 9 L. rubrilucens izolāti. Pārstāvētākā no serogrupām bija L. pneumophila serogrupa 3 (68 izolāti). Izmantojot SB…