Search results for " Macro"
showing 10 items of 522 documents
Polypeptides controlling hematopoietic blood cell development and activation
1989
Colony-stimulating factors (CSFs) have entered the clinical arena. Several investigators have explored, in first clinical phase I studies, different routes of administration to define the optimum biological dose, maximum tolerated dose, toxicity, and pharmacokinetics of these reagents. It has been demonstrated that recombinant human (rh) granulocyte-macrophage CSF (GM-CSF) and granulocyte CSF (G-CSF) can be safely administered over a broad dose range to increase number of circulating granulocytes in man. More recently, GM-CSF and G-CSF have been involved in phase Ib/II studies to assess the granulopoietic responses of patients with granulocytopenia due to various underlying disease states i…
Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
2011
Summary Background Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity. Objective To study the effects of the phosphodiesterase (PDE)-3 and 4 inhibitors and their combination vs. glucocorticoids in a model of lipopolysaccharide (LPS)-induced cytokine release in alveolar macrophages under oxidative stress conditions. Methods Differentiated U937 or human alveolar macrophages were stimulated with H2O2 (10–1000 μm) or cigarette smoke extract (CSE, 0–15%) for 4 h before LPS (0.5 μg/mL, 24 h) addition. In other experime…
Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF
1989
Abstract We assessed the capacity of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and multilineage (Multi)-CSF to induce release of granulocyte-CSF (G-CSF) by highly purified peripheral blood monocyte (Mo) preparations. Our results reveal that GM-CSF and Multi-CSF, either alone or in a synergistic concert, activate Mo to transcribe G-CSF messenger (m) RNA and release biologically active G- CSF protein into their culture supernatants. G-CSF had no regulatory effect on Mo expression of cytoplasmic G-CSF mRNA levels and G-CSF protein secretion by itself. These differential actions of CSFs provide further insight into self-regulatory mechanisms within the growth f…
Cytokine components and mucosal immunity in the oviduct of Xenopus laevis (amphibia, pipidae)
2011
Abstract Most studies on the mucosal immunity in female reproductive tissues have been performed in mammals. In all species, apart from their reproductive strategies, immunity in the genital mucosa is required to defend the host against luminal pathogens. In this study we investigated the role of the innate immunity of the oviductal mucosa of Xenopus laevis , an amphibian characterized by external fertilization. In particular we examined the expression and localization of Interleukin-1β (IL1B), Macrophage migration inhibitory factor (MIF) and Interleukin-1 receptor type 1 (IL1R1) in different oviductal portions including an upper glandular region, an intermediate and a lower aglandular regi…
Economic Globalization: From Microeconomic Foundation to National Determinants
2015
Abstract For many years, globalization was at the main source of economic growth for the world economy. During and after the 2009 crisis many questions about the positive effects of globalization have arisen. In this paper we argue there are two dimensions of economic globalization, micro and macro, and the perspectives of globalization is more related to the microeconomic determinants. Looking to the definitions and measures of globalization we conclude that for most of the countries the macro dimensions are important and many of them irreversible and not questionable in these days – barriers of trade, political integration, etc., but the microeconomic behavior of individuals and companies…
Incremental elastoplastic analysis for active macro-zones
2012
In this paper a strategy to perform incremental elastoplastic analysis using the symmetric Galerkin boundary element method for multidomain type problems is shown. The discretization of the body is performed through substructures, distinguishing the bem-elements characterizing the so-called active macro-zones, where the plastic consistency condition may be violated, and the macro-elements having elastic behaviour only. Incremental analysis uses the well-known concept of self-equilibrium stress field here shown in a discrete form through the introduction of the influence matrix (self-stress matrix). The nonlinear analysis does not use updating of the elastic response inside each plastic loop…
Un approccio innovativo per la modellazione degli edifici in muratura intelaiata. Applicazione ad un caso di studio
2013
Le strutture in muratura intelaiata rappresentano una parte rilevante delle strutture esistenti e sono ancora largamente adottate come sistema strutturale per la costruzione di edifici residenziali, soprattutto in aree del mondo a forte sismicità non fortemente industrializzate e nelle quali la muratura rappresenta ancora un materiale tradizionale e a basso costo. In questo lavoro viene presentato un approccio per macro-elementi per la valutazione della risposta sismica di strutture in muratura confinata. La complessa interazione tra il telaio e la muratura è simulata mediante un approccio originale in cui il telaio è modellato con aste a plasticità concentrata mentre il contributo della mu…
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
2020
2-Methoxyestradiol is one of the natural 17&beta
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
Wetland Restoration with Hydrophytes: A Review
2021
Restoration cases with hydrophytes (those which develop all their vital functions inside the water or very close to the water surface, e.g., flowering) are less abundant compared to those using emergent plants. Here, I synthesize the latest knowledge in wetland restoration based on revegetation with hydrophytes and stress common challenges and potential solutions. The review mainly focusses on natural wetlands but also includes information about naturalized constructed wetlands, which nowadays are being used not only to improve water quality but also to increase biodiversity. Available publications, peer-reviewed and any public domain, from the last 20 years, were reviewed. Several countrie…