Search results for " Maintenance."
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VERNACULAR ARCHITECTURE IN INSULAR ITALY: HERITAGE TO PRESERVE AND VALUE
2021
The Mediterranean civilisation, in its millenary history, has also expressed itself through particular artefacts that have strongly characterised the territory. Knowledge of the artefacts that "qualify" a territory, both in historical and material terms, is a necessary prerequisite for tackling the planning and management problems relating to their protection and conservation. The architecture of the "vernacular" is linked to domestic life, customs, the "dialects" of places and the essence of the Genius Loci. The building heritage of the islands surrounding Sicily features special building techniques and systems that exploit natural resources to generate original artefacts and extremely fun…
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…