Search results for " Major"
showing 10 items of 361 documents
Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase.
2018
BackgroundThere is uncertainty as to whether alterations in glutamatergic function in affective disorders differ between unipolar and bipolar disorders and between depressive and euthymic states. Additionally, there are currently no available blood-based markers of central glutamatergic function to support clinical diagnosis and aid brain based investigations. MethodsIn this study, we measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance Spectroscopy in medication free unipolar and bipolar patients (n=29, 20 unipolar and 9 bipolar) experiencing a major depressive episode, in comparison with a group of matched healthy controls (n=20). We als…
A monoamine oxidase B gene variant and short-term antidepressant treatment response.
2007
Genetic differences among patients suffering from Major Depression are likely to contribute to interindividual differences in medication treatment response. Thus, the identification of gene variants affecting drug response is needed in order to be able to predict response to psychopharmacological drugs. This study analyzed a possible association of the common A644G single nucleotide polymorphism (SNP) within intron 13 of the monoamine oxidase B (MAOB) gene with antidepressant treatment response. The study population consisted of n = 102 patients with major depression (criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; DSM-IV) participating in a randomized do…
Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depressio…
2011
Abstract In Major Depressive Disorder, a growing data base suggests that the onset of antidepressants’ action can be detected by improvement of depressive symptoms in the first 10–14 days of treatment. Previous studies showed that the mean concentration of the brain-derived neurotrophic factor (BDNF) in blood increases during antidepressant treatment and positively correlates with amelioration of MDD symptoms. We previously showed an association between very early changes of the serum BDNF concentration and treatment outcome ( Tadic et al., 2011 . Prog Neuropsychopharmacol Biol Psychiatry 35, 415–420). However, no study has yet investigated whether BDNF concentration in plasma increases in …
Chemical composition of essential oils from Pantelleria Island autochthonous and naturalized spices and evaluation of their individual and combined a…
2019
In this study, the antimicrobial activity of the essential oils (EOs) from Origanum majorana L. and Rosmarinus officinalis L. growing in Pantelleria (Sicily, Italy) were tested alone and in combination against some prokaryotic and eukaryotic food-borne pathogens. The chemical composition of the EOs as well as the minimum inhibitory concentrations (MIC) against the most sensitive strains were also determined. Both EOs showed interesting antimicrobial effects against all bacteria and yeasts tested. MIC was in the range 1.25–2.50 µl/ml. Interestingly, O. majorana was particularly rich in thymol acetate, while carvacrol was present at very low percentages. Also R. officinalis EOs composition wa…
Zvaigžņotā Debess: 2017, Rudens (237)
2017
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: U.Dzērvītis. Dispute on Hubble’s Constant Value (abridged) ; E.Mūkins. Ten «Venera»’s: Devices, Journeys and Results (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Orion Molecular Cloud Complex ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Salty Emanations of Enceladus ; R.Misa. Voyager: the Longest and Farthest ; OBSERVATORIES and INSTRUMENTS: J.Kuzmanis. Dragon Looks at the Sky ; K.Salmiņš. On ILRS Technical Workshop 2017 in Riga ; CONFERENCES and MEETINGS: M.Sudārs. Trends of Space Infrastructure Development in Europe ; M.Gills. Congress of European Planetary Science 2017 in Riga ; FLASHBACK: N.Cimahoviča. On Whirl…
Über die Hautzeichnungen des grossen Buntspechtes (Dendrocopus major L.): eine evolutionstheoretische Untersuchung [Par dižraibā dzeņa (Dendrocopus m…
1935
Teksts vācu valodā, kopsavilkums latviešu valodā.
Common variants conferring risk of schizophrenia
2009
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative ris…
Effective Majorana mass matrix from tau and pseudoscalar meson lepton number violating decays
2018
An observation of any lepton number violating process will undoubtedly point towards the existence of new physics and indirectly to the clear Majorana nature of the exchanged fermion. In this work, we explore the potential of a minimal extension of the Standard Model via heavy sterile fermions with masses in the $[ 0.1 - 10]$ GeV range concerning an extensive array of "neutrinoless" meson and tau decay processes. We assume that the Majorana neutrinos are produced on-shell, and focus on three-body decays. We conduct an update on the bounds on the active-sterile mixing elements, $|U_{\ell_\alpha 4} U_{\ell_\beta 4}|$, taking into account the most recent experimental bounds (and constraints) a…
Adaptive plasticity of blue tits(Parus caeruleus)and great tits(Parus major)breeding in natural and semi‐natural insular habitats
2004
The breeding performance and foraging of blue and great tits, and the abundance of arthropods living on the trees of an oak-wood and of a coniferous reafforestation were studied in Sicily, in order to: 1) compare breeding parameters in natural and semi-natural habitats within the same area; 2) estimate the degree of overlap in peak resource and peak demand of young tits, and the overlap of nestling diet of the two species in the two habitats. Both species had earlier laying dates, laid more eggs and raised more fledglings in the oakwood than in the reafforestation; they achieved the same fledging success within the same habitat type. These differences are probably due to the earlier and hig…
Rapid quantitative method for measuring phagocytosis of Leishmania promastigotes using a double radiolabelling method.
1990
A double radiolabelling method is described for the measurement of phagocytosis of Leishmania major promastigotes in cultures of murine resident peritoneal macrophages. L. major promastigotes were radiolabelled during exponential growth in RPMI supplemented with [125I]5-iodo-2-deoxyuridine. They were used to infect sodium [51Cr]chromate-labelled macrophages. Phagocytosis was evaluated by measuring the radioactivity of the 125IUdR-labelled parasites detectable inside 51Cr-labelled macrophages by a Beckmann gamma 5500 counting system. This was able to count simultaneously, in two different windows the radioactivity of (a) the parasites and (b) the cells. The technique compares favorably with …