Search results for " Major"

Sleep disorders in the elderly with and without chronic airflow obstruction: the SARA study

2003

Objectives: Our objectives were to test the hypothesis that, in the geriatric population, chronic airway obstruction is associated with a higher prevalence of sleep disturbances; to identify the main correlates of sleep disturbances, and to verify whether asthma and COPD patients have different patterns of sleep disturbances. Methods: The EPESE questionnaire was administered to 734 patients aged 65 years and over with asthma or chronic obstructive pulmonary disease (cases) and 1237 individuals of comparable age who were free of respiratory disease but not of other chronic conditions (controls). Four sleep disturbances were quantified: difficulty in falling asleep, nocturnal awakening, morni…

EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Ps…

2018

AbstractPhysical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder. We searched major electronic databases until January 2018 for systematic reviews with/without meta-analysis that investigated PA for any SMI. We rated the quality of studies with the AMSTAR tool, grading the quality of evidence, and identifying gaps, future research needs and clinical practice recommendations.…

Deconstructing incubation behaviour in response to ambient temperature over different timescales

2021

Avian embryos need a stable thermal environment to develop optimally, while incubat-ing females need to allocate time to self-maintenance off the nest. In species with female-only incubation, eggs are exposed to ambient temperatures that usually cool them down during female absences. The lower the ambient temperature the sooner females should return to re-warm the eggs. When incubation constraints ease at increasing ambient temperatures, females respond by increasing either incubation effort or self-maintenance time. These responses are population-dependent even within the same species; but it is uncertain whether they are caused by local environmental conditions or they are an artefact fro…

Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity

2006

Uptake of Leishmania major by dendritic cells (DCs) results in activation and interleukin (IL)-12 release. Infected DCs efficiently stimulate CD4- and CD8- T cells and vaccinate against leishmaniasis. In contrast, complement receptor 3-dependent phagocytosis of L. major by macrophages (MPhi) leads exclusively to MHC class II-restricted antigen presentation to primed, but not naive, T cells, and no IL-12 production. Herein, we demonstrate that uptake of L. major by DCs required parasite-reactive immunoglobulin (Ig)G and involved FcgammaRI and FcgammaRIII. In vivo, DC infiltration of L. major-infected skin lesions coincided with the appearance of antibodies in sera. Skin of infected B cell-de…

Skin Dendritic Cells in Murine Cutaneous Leishmaniasis

2002

Studies of the immunopathogenesis of Leishmania major-induced murine cutaneous leishmaniasis provide a framework for understanding the evolution of L. major infection of skin in humans and the foundation for rationale vaccine design. Experiments in which infection is initiated with "suprap hysiologic" numbers of parasites clearly identify Th-derived type I cytokines as essential participants in macrophage activation and macrophage nitric oxide production as prerequisite for parasite control. Dendritic cells, rather than macrophages, appear to be responsible for L. major-specific Th priming in these studies. Recent studies of murine cutaneous leishmaniasis in a model system in which infectio…

ANOMALIE DI MOVIMENTO DEL VENTRICOLO SINISTRO NEI PAZIENTI CON TALASSEMIA MAJOR

2014

CONTRATTILITÀ MIOCARDICA REGIONALE IN TALASSEMIA MAJOR TRAMITE TECNICA TAGGING IN RISONANZA MAGNETICA

2014

La cattedrale di Palermo

2015

Il volume ripercorre le principali vicende architettoniche della cattedrale di Palermo dalle origini fino al Novecento, individuandone nella sua complessa storia plurisecolare i committenti, gli artefici e i modelli di riferimento.

“The tale of the three little tits”: Different nest building solutions under the same environmental pressures

2020

Evolutionary selection pressures, and species-specific ecology and behavior, promote a great variability in the size and composition of nests. However, it would be expected that phylogenetically close species, with similar ecological needs, breeding at the same time in the same place, would also build similar nests. In contrast with this, previous studies have found differences in nest mass and composition among closely related sympatric species. These differences have been attributed to small differences in body size (smaller species building larger and/or more insulated nests), or to the different ways in which species perceive the environment (e.g. perceived predation risk). In this stud…

Evolution of topological superconductivity by orbital-selective confinement in oxide nanowires

2019

We determine the optimal conditions to achieve topological superconducting phases having spin-singlet pairing for a planar nanowire with finite lateral width in the presence of an in-plane external magnetic field. We employ a microscopic description that is based on a three-band electronic model including both the atomic spin-orbit coupling and the inversion asymmetric potential at the interface between oxide band-gap insulators. We consider amplitudes of the pairing gap, spin-orbit interactions and electronic parameters that are directly applicable to nanowires of LaAlO$_3$-SrTiO$_3$. The lateral confinement introduces a splitting of the $d$-orbitals that alters the orbital energy hierarch…