Search results for " Mal"
showing 10 items of 5318 documents
Zero-contrast percutaneous coronary interventions to preserve kidney function in patients with severe renal impairment and hemodialysis subjects
2019
Introduction Zero-contrast percutaneous coronary intervention (zero-PCI) is a new method for prevention of contrast-induced acute kidney injury (AKI) in patients with chronic kidney disease (CKD). However, evidence for its feasibility, safety and clinical utility is limited to reports of single cases or series of patients. Aim To present outcomes of zero-PCI in patients with severe CKD, including hemodialysis subjects, who were treated with this procedure in order to preserve their renal function. Material and methods Twenty-nine zero-PCIs were performed, mostly as a staged procedure, in 20 patients with advanced CKD. In this group, 4 patients were treated with hemodialysis but presented pr…
Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma.
2002
Heat shock proteins (HSP) are families of highly conserved proteins which are induced in cells and tissues upon exposure to extreme conditions causing acute or chronic stress. They exhibit distinct functions and have been implicated in the pathogenesis of a number of diseases, including cancer. A causal relationship between HSP expression and immunogenicity has been demonstrated in murine and human tumors and is also associated with the immune response. In order to investigate the correlation of HSP expression and their immunogenic potential in renal cell carcinoma (RCC), we here analyzed (i) the protein expression profile of various members of the HSP family in untreated and interferon (IF…
Interferon-beta: a therapeutic for autoimmune lupus in MRL-Faslpr mice.
2005
Type I interferons are associated with lupus. Genes that are regulated by IFN-alpha are upregulated in pediatric lupus patients. Gene deletion of the IFN-alpha/beta receptor in experimental lupus-like NZB mice results in reduced disease activity. Conversely, IFN-beta is a well-established treatment in multiple sclerosis, another autoimmune disease. For determining whether IFN-beta treatment is harmful or beneficial in lupus, MRL-Fas(lpr) mice were injected with this type I IFN. Treatment was initiated in MRL-Fas(lpr) mice with mild and advanced disease. IFN-beta was highly effective in prolonging survival and ameliorating the clinical (renal function, proteinuria, splenomegaly, and skin les…
Evaluation of orthognathic surgery on articular disc position and temporomandibular joint symptoms in skeletal class II patients: A Magnetic Resonanc…
2017
BACKGROUND The purpose of orthognathic surgery is to correct facial deformity and dental malocclusion and to obtain normal orofacial function. However, there are controversies of whether orthognathic surgery might have any negative influence on temporomandibular (TM) joint. The purpose of this study was to evaluate the influence of orthognathic surgery on articular disc position and temporomandibular joint symptoms of skeletal CI II patients by means of magnetic resonance imaging. MATERIAL AND METHODS For this purpose, fifteen patients with skeletal CI II malocclusion, aged 19-32 years (mean 23 years), 10 women and 5 men, from the Isfahan Department of Oral and Maxillofacial Surgery were st…
An Anti-Ubiquitin Antibody Response in Transitional Cell Carcinoma of the Urinary Bladder
2015
BackgroundTo use combinatorial epitope mapping ("fingerprinting") of the antibody response to identify targets of the humoral immune response in patients with transitional cell carcinoma (TCC) of the bladder.MethodsA combinatorial random peptide library was screened on the circulating pool of immunoglobulins purified from an index patient with a high risk TCC (pTa high grade plus carcinoma in situ) to identify corresponding target antigens. A patient cohort was investigated for antibody titers against ubiquitin.ResultsWe selected, isolated, and validated an immunogenic peptide motif from ubiquitin as a dominant epitope of the humoral response. Patients with TCC had significantly higher anti…
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
Stability of Thermoelastic Layered Composite in Axial Movement
2018
Melanoma Oculare
2008
Malvinas, las islas prometidas. Aproximaciones a la literatura de la guerra
2018
Resumen: El presente artículo propone, en primer lugar, un acercamiento a la construcción nacional del relato sobre las Islas Malvinas. En segunda instancia se realiza un recorrido por la literatura que aborda la guerra de Malvinas a partir de tres focos narrativos: 1982-1989, 1990-2001 y 2002-2017. La periodización responde a las diferentes generaciones pero también a los procesos sociales que han acompañado una transformación política y cultural en Argentina. Finalmente, y como modo de detectar los principales géneros, tramas y conflictos narrativos que han surgido hasta este momento, se analizan las obras más representativas de cada periodo.
Solving classification problems with multicriteria decision aiding approaches
2007
Iryna Yevseyevan väitöskirjan aiheena on päätöksentekijän avustaminen hänen ratkaistessaan vaativia ja monimutkaisia luokittelutehtäviä. Tällaisia tehtäviä esiintyy erityyppisessä diagnostiikassa, esimerkiksi lääketieteen alalla lääkärin diagnosoidessa potilasta, tekniikan alalla insinöörin määrittäessä koneen rikkoutumisen syytä tai talouden alalla sijoittajan arvioidessa riskejä ennen sijoituspäätöstä.Yevseyevan tutkimat ja kehittämät menetelmät ovat avuksi silloin, kun luokittelupäätökset ovat riippuvaisia päätöksentekijän subjektiivisesta tietämyksestä, intuitiosta ja mieltymyksistä. Esitetyt menetelmät mahdollistavat ongelmakentän määrittelyn ja formalisoinnin, ja lisäksi ne tarjoavat …