Search results for " Maps"
showing 10 items of 198 documents
Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1
2020
Background: Several experimental models of polyglutamine (polyQ) diseases have been previously developed that are useful for studying disease progression in the primarily affected central nervous system. However, there is a missing link between cellular and animal models that would indicate the molecular defects occurring in neurons and are responsible for the disease phenotype in vivo. Methods: Here, we used a computational approach to identify dysregulated pathways shared by an in vitro and an in vivo model of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ disease spinocerebellar ataxia type-1 (SCA1). Results: A set of common dysregulated pathwa…
Multivariate statistical analysis of a large odorants database aimed at revealing similarities and links between odorants and odors
2017
International audience; The perception of odor is an important component of smell; the first step of odor detection, and the discrimination of structurally diverse odorants depends on their interactions with olfactory receptors (ORs). Indeed, the perception of an odor's quality results from a combinatorial coding, in which the deciphering remains a major challenge. Several studies have successfully established links between odors and odorants by categorizing and classifying data. Hence, the categorization of odors appears to be a promising way to manage odors. In the proposed study, we performed a computational analysis using odor descriptions of the odorants present in Flavor-Base 9th Edit…
The social networks of young people with intellectual disabilities during the On-Campus supported adult education programme
2016
<p>This article describes the social networks of four young people with intellectual disabilities in supported adult education, focusing on their inclusion in school and leisure environments. A multiple case study approach with content analysis was used. Data were collected through interviews with young people and their family members, relationship maps, observation journals and notes from Personal Futures Planning meetings. Relationships with family members, other relatives and neighbours were close. One participant had a friend of her own age with no disabilities. The other three had varying, superficial peer relationships and friends of the family. All the participants had heteroge…
Una segregazione paradossale e multi-scalare: il caso del quartiere ZEN di Palermo
2016
L’articolo affronta la questione della segregazione nel quartiere ZEN di Palermo (Sicilia). L’impianto teorico dialoga con la letteratura anglosassone, ma ne prende le distanze nel tentativo di individuare alcune specificità locali del caso. L’obiettivo è duplice: intanto indentificare alcuni “movimenti geostorici” che hanno caratterizzato il quartiere, collegando a ciascuno di questi una fase del processo segregativo; inoltre, rappresentare la segregazione del quartiere in forma cartografica, mediante l’uso di alcuni ideogrammi e mappe mentali. This article deals with the issue of segregation in the ZEN district of Palermo, Sicily. The theoretical framework is built around Anglo-Saxon refe…
The geometers of the cadastre of Catalonia (1720-1815)
2009
El Cadastre imposat a Catalunya després de la derrota austriacista en la guerra de Successió comportà la realització de nombroses operacions de mesura de terres. Aquests treballs foren duts a terme per un petit cos d’agrimensors anomenats geòmetres del reial tribut del Cadastre. Entre 1727 i 1815 n’hem identificat un total de vint-i-dos geòmetres. La creació d’aquesta figura va fer visible una professió fins llavors força desdibuixada a Catalunya. La cartografia cadastral és modesta, però alguns d’aquests geòmetres realitzaren també mapes més elaborats amb altres finalitats. After the Austrian defeat in the War of the Spanish Succession a cadastre was imposed to Catalonia. That entailed the…
Radio environment map estimation based on communication cost modeling for heterogeneous networks
2017
Los mapas del entorno radioeléctrico pueden ser una poderosa herramienta para lograr una asignación de recursos eficiente y consciente del contexto en las redes heterogéneas 5G. En este trabajo, consideramos una red heterogénea formada por una red celular tradicional y una red de sensores inalámbricos. El papel de la red de sensores inalámbricos es estimar el mapa del entorno radioeléctrico de la célula utilizando una técnica de interpolación geoestadística denominada Kriging. En un trabajo anterior se propuso un algoritmo de agrupación distribuida de sensores para reducir la complejidad de la estimación. En nuestra contribución, el proceso de formación de clústeres se modifica para incluir…
Distributed radio map reconstruction for 5G automotive
2018
Se espera que los mapas de entorno radio sean una herramienta esencial para la optimización y gestión de recursos del 5G en vehículos. En este trabajo, consideramos el problema de la reconstrucción del mapa de entorno radio utilizando una red de sensores inalámbricos formada por nodos sensores en vehículos, nodos de acceso de una infraestructura de ciudad inteligente, etc. Debido a las limitaciones de recursos en las redes de sensores, es crucial seleccionar un pequeño número de mediciones de los sensores para reconstruir el campo. En este contexto, presentamos un novedoso algoritmo distribuido basado en el método de regresión Kriging para la reconstrucción del mapa de entorno radio en térm…
A low complexity distributed cluster based algorithm for spatial prediction
2017
Los mapas del entorno radioeléctrico (REM) pueden ser una herramienta esencial para numerosas aplicaciones en las futuras redes inalámbricas 5G. En este trabajo, empleamos un popular método geoestadístico llamado kriging ordinario para estimar el REM de un área cubierta por un eNodeB equipado con múltiples antenas. Los sensores inalámbricos se distribuyen por el área de interés y se organizan clústeres adaptativos de sensores para mejorar la calidad de la estimación del canal. En este trabajo, modificamos el algoritmo de clustering distribuido propuesto en un trabajo anterior para reducir la complejidad de la predicción de kriging. Se realizan simulaciones para detallar la técnica de formac…
Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers
2020
Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins correlated with carcinogenesis. The DAVID functional classification tool revealed that most of the differentially regulated proteins, acting both intracellularly and extracellularly, concur across multiple cancer steps. The identified protein classes include proteins involved in cell proliferation, apoptosis, metabolic pathways, oxidative stress, cell motility, Ras signal transdu…
Key issues in decomposing fMRI during naturalistic and continuous music experience with independent component analysis
2014
Background: Independent component analysis (ICA) has been often used to decompose fMRI data mostly for the resting-state, block and event-related designs due to its outstanding advantage. For fMRI data during free-listening experiences, only a few exploratory studies applied ICA.New method: For processing the fMRI data elicited by 512-s modern tango, a FFT based band-pass filter was used to further pre-process the fMRI data to remove sources of no interest and noise. Then, a fast model order selection method was applied to estimate the number of sources. Next, both individual ICA and group ICA were performed. Subsequently, ICA components whose temporal courses were significantly correlated …