Search results for " Mar"

Periodontal disease associated to systemic genetic disorders

2007

A number of systemic disorders increase patient susceptibility to periodontal disease, which moreover evolves more rapidly and more aggressively. The underlying factors are mainly related to alterations in immune, endocrine and connective tissue status. These alterations are associated with different pathologies and syndromes that generate periodontal disease either as a primary manifestation or by aggravating a pre-existing condition attributable to local factors. This is where the role of bacterial plaque is subject to debate. In the presence of qualitative or quantitative cellular immune alterations, periodontal disease may manifest early on a severe localized or generalized basis - in s…

Global connectivity between commodity prices and national stock markets: A time‐varying MIDAS analysis

2021

Hidden Markov Random Fields and Direct Search Methods for Medical Image Segmentation

2016

The goal of image segmentation is to simplify the representation of an image to items meaningful and easier to analyze. Medical image segmentation is one of the fundamental problems in image processing field. It aims to provide a crucial decision support to physicians. There is no one way to perform the segmentation. There are several methods based on HMRF. Hidden Markov Random Fields (HMRF) constitute an elegant way to model the problem of segmentation. This modelling leads to the minimization of an energy function. In this paper we investigate direct search methods that are Nelder-Mead and Torczon methods to solve this optimization problem. The quality of segmentation is evaluated on grou…

Graphical models for estimating network determinants of multi-destination trips in Sicily

2017

Abstract This paper proposes a two-step approach for analysing the main determinants of multi-destination trip behaviour. It is based on a combination of graphical models and of a multinomial logistic regression model; the aim is to analyse direct and indirect effects of a wide set of tourist- and trip-related characteristics on multi-destination trip behaviour. Empirical data have been derived from a frontier survey of approximately 4000 incoming tourists in Sicily (Italy) at the end of their trip. Results suggest that multi-destination trips depend directly on the length of stay, the number of previous visits and motivation for the trip, and only indirectly on the interview month, travel …

ANÁLISIS DE LOS HOTELES DE ALTA CATEGORÍA DE CROACIA DESDE EL ENFOQUE HOTEL-HUÉSPED

2011

RESUMENCroacia viene experimentando un auge turístico notable en los últimos diez años. Es crucial para su futuro desarrollo saber gestionar el sector hotelero de acuerdo con las nuevas exigencias del mercado. Este trabajo pretende analizar los hoteles de alta categoría de Croacia desde un doble enfoque hotel-huésped, centrándose en una nueva estrategia de marketing denominada Comunicación Integrada de Marketing (CIM), los avances en las Tecnologías de Información y Comunicación (TIC) y la lealtad. Los resultados demuestran el elevado grado de implantación de las TIC y de la CIM y el grado moderado de los programas de lealtad en los hoteles analizados. Además, confirman la influencia de las…

Knowledge transfer mechanisms in franchise network

2020

PurposeThe purpose of this paper is to investigate the use of knowledge transfer (KT) mechanisms in a franchise network.Design/methodology/approachThis study uses qualitative and grounded theory techniques to collect and analyze data from a franchise network based in Africa. This approach enables the triangulation of data from different sources including field visits, observation, interviews and company reports.FindingsThe findings suggest that training is the most preferred mechanisms for transferring localized knowledge. The results highlight the importance of identifying franchisees’ training needs for transferring relevant knowledge according to experience and market profile of franchis…

Distinctive Patterns of Intraclonal Diversification In IGHV1-2*04 Immunoglobulin Receptors of Patients with Splenic Marginal Zone Lymphoma: A of Ongo…

2011

Abstract Abstract 2638 We recently demonstrated that over 30% of cases with splenic marginal-zone lymphoma (SMZL) express distinctive immunoglobulin (IG) receptors that utilize a single polymorphic variant of the IGHV1-2 gene (IGHV1-2*04) and also exhibit restricted antigen-binding site motifs and precise targeting of somatic hypermutation (SHM). On these grounds, we proposed the existence of molecular subtypes of SMZL defined by immunogenetic analysis of the IG receptors with implications for selection by specific (super) antigenic element(s) in the development of at least a major subset of SMZL. In order to gain insight as to whether antigen involvement is relevant only prior to the malig…

Disseminating scientific research: a double-edged sword?

2017

Practitioners rarely have the time or propensity to read scientific research, and scholarly researchers seldom write for non-academic audiences. Nevertheless, both groups would probably agree that researchers could solve many problems faced by practitioners and that research is important to guide practice. This article acknowledges scientists’ failure to communicate successfully with practitioners, and discusses the main differences between academic and practitioner-oriented journals in management and business related disciplines. Author guidelines of the most prominent journals that appeal to both academics and practitioners are reviewed and discussed. A thorough literature review is also …

Predicting shifting sustainability trade-offs in marine finfish aquaculture under climate change

2018

Defining sustainability goals is a crucial but difficult task because it often involves the quantification of multiple interrelated and sometimes conflicting components. This complexity may be exacerbated by climate change, which will increase environmental vulnerability in aquaculture and potentially compromise the ability to meet the needs of a growing human population. Here, we developed an approach to inform sustainable aquaculture by quantifying spatio-temporal shifts in critical trade-offs between environmental costs and benefits using the time to reach the commercial size as a possible proxy of economic implications of aquaculture under climate change. Our results indicate that optim…

Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow

2014

How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobilization and apoptosis of HSCs in vivo. A switch from glycolysis to mitochondrial respiration with increased reactive oxygen species (ROS) level was also observed in HSCs on pfn1 deletion. Importantly, treatment of pfn1-deficient mice with the antioxidant N-acetyl-l-cysteine reversed the ROS level and loss of quiescence of HSCs, suggesting that the metabolism is mechanistically linked to the cell…