Search results for " Matrix"

showing 10 items of 2053 documents

Rapid antibiotic susceptibility testing on blood cultures using MALDI-TOF MS

2018

International audience; Antibiotic resistance is a major public health problem requiring the early optimization of antibiotic prescriptions. Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry (MALDI-TOF MS) has been shown to accurately identify bacteria from positive blood culture. Here, we developed a rapid detection of Escherichia coli resistance to amoxicillin (AMX) and cefotaxime (CTX) from positive blood culture based on MALDI-TOF MS. Potential sparing of broad-spectrum antibiotics was also evaluated. We tested 103 E. coli-positive blood cultures. Blood cultures were subculture 1-hour in antibiotic-free rich liquid media before further incubation with and with…

Agar Dilution Method0301 basic medicineTime FactorsCefotaximePhysiologyAntibioticslcsh:MedicineCefotaximeDrug resistancemedicine.disease_causeMass SpectrometryAnalytical ChemistrySpectrum Analysis TechniquesAntibioticsMicrobial PhysiologyMedicine and Health SciencesBlood cultureMatrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometrylcsh:ScienceMultidisciplinarymedicine.diagnostic_testbiologyAntimicrobialsChemistryMicrobial Growth and DevelopmentDrugsMatrix-Assisted Laser Desorption Ionization Mass SpectrometryBody FluidsAnti-Bacterial Agents3. Good healthChemistryBlood[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyPhysical SciencesAnatomyResearch Articlemedicine.drugmedicine.drug_class030106 microbiologyMicrobial Sensitivity TestsResearch and Analysis MethodsMicrobiologyAntibiotic Susceptibility TestingMicrobiology03 medical and health sciencesMicrobial ControlDrug Resistance BacterialEscherichia colimedicineHumansEscherichia coliPharmacologyBacteriological TechniquesBacterial Growthlcsh:RBiology and Life SciencesAmoxicillinAmoxicillinbiology.organism_classificationPharmacologic AnalysisBlood CultureAntibiotic ResistanceSpectrometry Mass Matrix-Assisted Laser Desorption-Ionizationlcsh:QAntimicrobial ResistanceSubculture (biology)BacteriaDevelopmental BiologyPLOS ONE
researchProduct

Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases.

2006

Background: The effects of the bisphosphonate derivative zoledronic acid (ZA) on the > circulating levels of matrix metalloproteinase-2 (MMP-2), matrix metallo-proteinases-9 > (MMP-9), cathepsin B (Cath B) and urokinase-type plasminogen activator (uPA) in > patients with bone metastasis (BMTS) and the possible correlation with the symptomatic > response induced by this drug in these patients were evaluated. Patients and Methods: > Proteinase levels were determined by enzyme-linked immunosorbent assay (ELISA) in the > plasma of 30 patients with painful bone metastases from breast or prostate cancer > undergoing multiple treatment with ZA (4 mg i.v., every 4 weeks). Healthy subjects > (HS) of…

Aged 80 and overMaleBone Density Conservation AgentsDiphosphonatesZoledronic > acidImidazolesProstatic NeoplasmsBone NeoplasmsBreast NeoplasmsMiddle AgedProteinaseZoledronic AcidCathepsin BMatrix > metalloproteinase-9Matrix Metalloproteinase 9Matrix metalloproteinase-2Bone metastasiBisphosphonates; Bone metastasis; Cathepsin B; Matrix metalloproteinase-2; Matrix > metalloproteinase-9; Proteinases; Urokinase-type plasminogen activator; Zoledronic > acidHumansMatrix Metalloproteinase 2BisphosphonateFemaleUrokinase-type plasminogen activatorAged
researchProduct

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING

2022

Ageing is intimately connected to the induction of cell senescence(1,2), but why this is so remains poorly understood. A key challenge isthe identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing(3). Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing. Conversely, sustaining YAP function rejuvenates old cells and opposes the e…

AgingMechanotransductionActin-Related Protein 2; Cellular Senescence; Extracellular Matrix; Healthy Aging; Immunity Innate; Lamin Type B; Mechanotransduction Cellular; Nuclear Envelope; Signal Transduction; Aging; Membrane Proteins; Nucleotidyltransferases; Stromal Cells; Transcriptional Coactivator with PDZ-Binding Motif Proteins; YAP-Signaling ProteinsNuclear EnvelopeSettore MED/08 - Anatomia PatologicaYAP TAZ ageing C-GAS STINGMechanotransduction CellularArticleHealthy AgingInnateCellular SenescenceAdaptor Proteins Signal TransducingMultidisciplinaryLamin Type BImmunityMembrane ProteinsYAP-Signaling ProteinsPhosphoproteinsNucleotidyltransferasesImmunity InnateExtracellular MatrixTranscriptional Coactivator with PDZ-Binding Motif ProteinsActin-Related Protein 2CellularStromal CellsSignal Transduction
researchProduct

Aroma release in the oral cavity after wine intake is influenced by wine matrix composition

2018

The aim of this study has been to investigate if wine matrix composition might influence the interaction between odorants and oral mucosa in the oral cavity during a “wine intake-like” situation. Aroma released after exposing the oral cavity of three individuals to different wines (n = 12) previously spiked with six target aromas was followed by an -in vivo intra-oral SPME approach. Results showed a significant effect of wine matrix composition on the intra-oral aroma release of certain odorants. Among the wine matrix parameters, phenolic compounds showed the largest impact. This effect was dependent on their chemical structure. Some phenolic acids (e.g. hippuric, caffeic) were associated t…

Alcohol DrinkingAroma-wine matrix interactions[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionIntra-oral aroma releasephenolic metabolitessalivary proteinsWineperceptionGas Chromatography-Mass SpectrometryAnalytical ChemistrytanninMatrix (chemical analysis)chemistry.chemical_compound0404 agricultural biotechnologyPhenolic compositionLinaloolmodel wineHumansFood scienceAromaWineMouthChromatographybiologyretronasal aromaEthyl hexanoatefood and beverages04 agricultural and veterinary sciencesGeneral Medicinered wineWine faultbiology.organism_classificationhuman feces040401 food sciencestomatognathic diseaseschemistryWineIntra-oral aroma releaseOdorantsmolecular-levelComposition (visual arts)Oral mucosaGas chromatography–mass spectrometryheadspace[SDV.AEN]Life Sciences [q-bio]/Food and NutritionFood ScienceAroma persistence
researchProduct

A note on cocharacter sequence of Jordan upper triangular matrix algebra

2016

Let UJn(F) be the Jordan algebra of n × n upper triangular matrices over a field F of characteristic zero. This paper is devoted to the study of polynomial identities satisfied by UJ2(F) and UJ3(F). In particular, the goal is twofold. On one hand, we complete the description of G-graded polynomial identities of UJ2(F), where G is a finite abelian group. On the other hand, we compute the Gelfand–Kirillov dimension of the relatively free algebra of UJ2(F) and we give a bound for the Gelfand–Kirillov dimension of the relatively free algebra of UJ3(F).

Algebra and Number TheoryJordan algebraQuaternion algebraMathematics::Rings and Algebras010102 general mathematicsZero (complex analysis)Triangular matrixgrowth of algebras010103 numerical & computational mathematics01 natural sciencesgraded Jordan algebraCombinatoricsAlgebraFiltered algebraSettore MAT/02 - AlgebraDifferential graded algebraFree algebraAlgebra representationGraded identitie0101 mathematicsMathematics
researchProduct

POSITIVE DEFINITE FUNCTIONS OF DIAGONAL LIMITS OF FINITE ALTERNATING GROUPS

2004

The normalized positive definite class functions are determined for all those direct limits of finite alternating groups for which the embeddings are natural in the sense that every non-trivial -orbit in is natural.

AlgebraPure mathematicsClass (set theory)General MathematicsDiagonalPositive-definite matrixOrbit (control theory)MathematicsJournal of the London Mathematical Society
researchProduct

Star-products and phase space realizations of quantum groups

1992

It is shown for a family of *-products (i.e. different ordering rules) that, under a strong invariance condition, the functions of the quadratic preferred observables (which generate the Cartan subalgebra in phase space realization of Lie algebras) take only the linear or exponential form. An exception occurs for the case of a symmetric ordering *-product where trigonometric functions and two special polynomials can also be included. As an example, the ‘quantized algebra’ of the oscillator Lie algebra is argued.

AlgebraPure mathematicsSubalgebraCartan matrixCartan subalgebraReal formStatistical and Nonlinear PhysicsKilling formKac–Moody algebraMathematical PhysicsMathematicsLie conformal algebraGraded Lie algebraLetters in Mathematical Physics
researchProduct

Oxygen profile of microencapsulated islets: effect of immobilised hemoglobin in the alginate matrix

2001

AlginatesAlginate matrixCell Culture TechniquesIslets of Langerhans Transplantationchemistry.chemical_elementCapsulesOxygenHemoglobinsIslets of LangerhansOxygen ConsumptionInsulin SecretionAnimalsInsulinTransplantationgeographygeography.geographical_feature_categoryChromatographyFishesMetabolismIsletCell MicroenvironmentGlucosechemistryBiochemistrySurgeryHemoglobinPolarographyTransplantation Proceedings
researchProduct

Analysis of a database to predict the result of allergy testing in vivo in patients with chronic nasal symptoms and the development of the software A…

2014

Background. This thesis consist of parts(i)Introduction in wich we present the clinical problem of rhinitis;(ii)the methods to evaluate the diagnostic choises;(iii)the rational errors in Allergy,(iv)the experimental part of thesis with wich we developed the software ARTSTAT,wich is the application of the analysis reported.Objective: We studied the ability of the logistic regression model obtained by the evaluaqtion of a database, to detect patients with positive allergy skin prick test(SPT)and patients with negative SPT. The model developed was valitated using the data set obtained from another medical institution. Methods: The analysis was carried out using a database obtained from a quest…

Allergic rhinitis Nonallergic rhinitis Decision Matrix Logistic regression model Receiver Operating Characteristic curve probability Diagnostic decision making nasal symptom Skin prick test (SPT) Cognitive Errors
researchProduct

Classifying Healthy Children and Children with Attention Deficit through Features Derived from Sparse and Nonnegative Tensor Factorization Using Even…

2010

In this study, we use features extracted by Nonnegative Tensor Factorization (NTF) from event-related potentials (ERPs) to discriminate healthy children and children with attention deficit (AD). The peak amplitude of an ERP has been extensively used to discriminate different groups of subjects for the clinical research. However, such discriminations sometimes fail because the peak amplitude may vary severely with the increased number of subjects and wider range of ages and it can be easily affected by many factors. This study formulates a framework, using NTF to extract features of the evoked brain activities from time-frequency represented ERPs. Through using the estimated features of a ne…

Amplitudebusiness.industryEvent-related potentialAttention deficitMismatch negativityPattern recognitionNonnegative matrixArtificial intelligenceNonnegative tensor factorizationbusinessOddball paradigmNon-negative matrix factorizationMathematics
researchProduct