Search results for " Matrix"

Different adhesins for type IV collagen on Candida albicans: identification of a lectin-like adhesin recognizing the 7S(IV) domain

2001

Adherence of the opportunistic pathogen Candida albicans to basement membrane (BM) proteins is considered a crucial step in the development of candidiasis. In this study the interactions of C. albicans yeast cells with the three main domains of type IV collagen, a major BM glycoprotein, were analysed. C. albicans adhered to the three immobilized domains by different mechanisms. Adhesion to the N-terminal cross-linking domain (7S) required the presence of divalent cations, whereas interaction with the central collagenous domain (CC) was cation-independent. Recognition of the C-terminal non-collagenous domain (NC1) was partially cation-dependent. Binding inhibition assays with the correspondi…

Osteonectin Expression in Odontogenous and Non-odontogenous Tumors and Tumor-like Lesions of the Skull and Jaw Bones

1988

The organic matrix of osseous and odontogenic tissues is formed mainly by collagen type I. In addition there is a considerable bulk of noncollagenous proteins (Prince et al. 1987) in bone among which osteonectin represents the greatest amount. This protein, first isolated by Termine et al. (1981) has a molecular weight of 29 kD and possibly is involved in the mineralization process of collagenous fibrils in bone (Romberg et al. 1985). Recently osteonectin could be demonstrated in bone tumors and normal bone and has been considered as a marker for bone tumor cells (Schulz et al. 1985; Jundt et al. 1987). The aim of the present study was to examine the expression of osteonectin in odontogenou…

Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma

2021

Treatment in children with high-risk neuroblastoma remains largely unsuccessful due to the development of metastases and drug resistance. The biological complexity of these tumors and their microenvironment represent one of the many challenges to face. Matrix glycoproteins such as vitronectin act as bridge elements between extracellular matrix and tumor cells and can promote tumor cell spreading. In this study, we established through a clinical cohort and preclinical models that the interaction of vitronectin and its ligands, such as αv integrins, are related to the stiffness of the extracellular matrix in high-risk neuroblastoma. These marked alterations found in the matrix led us to speci…

Permutation properties and the fibonacci semigroup

1989

Transitive factorizations in the hyperoctahedral group

2008

The classical Hurwitz enumeration problem has a presentation in terms of transitive factor- izationsin the symmetric group. This presentationsuggestsageneralizationfromtypeAto otherfinite reflection groups and, in particular, to type B.W e study this generalization both from ac ombinatorial and a geometric point of view, with the prospect of providing am eans of understanding more of the structure of the moduli spaces of maps with an S2-symmetry. The type A case has been well studied and connects Hurwitz numbers to the moduli space of curves. W ec onjecture an analogous setting for the type B case that is studied here. 1I ntroduction Transitive factorizations of permutations into transposit…

An algorithm to find all paths between two nodes in a graph

1990

The irregularity strength of circulant graphs

2005

AbstractThe irregularity strength of a simple graph is the smallest integer k for which there exists a weighting of the edges with positive integers at most k such that all the weighted degrees of the vertices are distinct. In this paper we study the irregularity strength of circulant graphs of degree 4. We find the exact value of the strength for a large family of circulant graphs.

Covering and differentiation

1995

New structural parameters of fullerenes for principal component analysis

2003

The Kekule structure count and the permanent of the adjacency matrix of fullerenes are related to structural parameters involving the presence of contiguous pentagons p, q, r, q/p and r/p, where p is the number of edges common to two pentagons, q is the number of vertices common to three pentagons and r is the number of pairs of nonadjacent pentagons adjacent to another common pentagon. The cluster analysis of the structural parameters allows classification these parameters. Principal component analysis (PCA) of the structural parameters and the cluster analyses of the fullerenes permit their classification. PCA clearly distinguishes five classes of fullerenes. The cluster analysis of fulle…

On lacunary Toeplitz determinants

2014

By using Riemann--Hilbert problem based techniques, we obtain the asymptotic expansion of lacunary Toeplitz determinants $\det_N\big[ c_{\ell_a-m_b}[f] \big]$ generated by holomorhpic symbols, where $\ell_a=a$ (resp. $m_b=b$) except for a finite subset of indices $a=h_1,\dots, h_n$ (resp. $b=t_1,\dots, t_r$). In addition to the usual Szeg\"{o} asymptotics, our answer involves a determinant of size $n+r$.