Search results for " Mesenchymal"

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Stem Cell Therapy

2019

The necessity of improving the health and quality of life of subjects affected by diverse injuries and chronic diseases, has led to develop a new branch of translational medicine, called Regenerative Medicine (RegMed). RegMed has the principal objects of restoring, maintaining or enhancing structures and functions of tissues and organs. In order to achieve these goals, the RegMed researchers have proposed and tested diverse approaches. The Stem Cell Therapy represents the central focus of RegMed, even if its applications may imply the onset of adverse conditions. Here, an overview of this topic will be reported, by pointing advantages and disadvantages.

mesenchymal stem cellsbusiness.industrymedicine.medical_treatmentfibrosisregenerative medicineStem-cell therapybenefits and limitationsstem cell therapyangiogenesistranslational medicinegrowth factors/cytokinesCancer researchSettore MED/05 - Patologia ClinicaMedicinebusinessangiogenesis; benefits and limitations; fibrosis; growth factors/cytokines; mesenchymal stem cells; regenerative medicine; stem cell therapy; translational medicine
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CHARACTERIZATION AND ENERGETIC METABOLISM ANALYSIS OF DIFFERENT POPULATIONS OF UMBILICAL CORD MESENCHYMAL STEM CELLS FOR THE TREATMENT OF STROKE

Stroke is a leading cause of death and disability worldwide. A direct consequence of oxygen and glucose deprivation during stroke is the dysfunction of mitochondria that impairs oxidative metabolism and contributes to oxidative stress, neuronal death and inflammation. Human umbilical cord (UC)-derived MSCs (UC-MSCs) are an attractive source for regenerative medicine purposes due to their self-renewal and multipotent differentiation potential, immunomodulatory and anti-inflammatory abilities. Notably, because UC is supplied from only three blood vessels, the UC-MSCs are physiologically adapted to survive in a relatively hypoxic and glucose poor environment leading to the hypothesis that thes…

mitochondriaSettore BIO/17 - IstologiaCL-MSCPV-MSCSeahorse analyzerUmbilical cord mesenchymal stem cellWJ-MSCstrokemass spectrometry
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