Search results for " Middle"

showing 10 items of 1097 documents

Effectiveness of high dose sublingual immunotherapy to induce a stepdown of seasonal asthma: a pilot study

2009

There is ample evidence to support the efficacy of sublingual immunotherapy (SLIT) on allergic rhinitis, while there is less solid data regarding asthma. We evaluated the effects of a high dose birch SLIT on birch-induced rhinitis and asthma in a controlled study.This double-blind, placebo-controlled, randomised, single centre trial on SLIT with birch pollen allergen extract (Stallergenes, Antony, France) included 24 patients presenting severe rhinitis and slight to moderate asthma, 14 actively and 10 placebo treated. SLIT was performed by a pre-coseasonal protocol, and was repeated for 2 years. The study plan included a selection visit, a visit at the start of the first and the second trea…

AdultMalemedicine.medical_specialtyModerate asthmaDouble-Blind Method; Humans; Immunotherapy; Seasons; Adult; Asthma; Placebos; Pilot Projects; Middle Aged; Male; Female; Drug Administration RoutesPilot ProjectsPlacebolaw.inventionPlacebosSeasonal asthmaRandomized controlled trialDouble-Blind MethodlawInternal medicinemedicineHumansSublingual immunotherapyPilot ProjectPlaceboAsthmabusiness.industryDrug Administration RoutesGeneral MedicineMiddle Agedmedicine.diseaseSlitAsthmaSurgerySingle centreFemaleSeasonsImmunotherapySeasonSLIT asthma allergybusinessHuman
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"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxa…

2010

BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = …

AdultMalemedicine.medical_specialtyMultivariate analysisColorectal cancerSettore MED/06 - Oncologia MedicaKaplan-Meier EstimateGastroenterologyDisease-Free SurvivalCapecitabineTreatment Outcome; Prognosis; Aged 80 and over; Male; Retrospective Studies; Randomized Controlled Trials as Topic; Middle Aged; Kaplan-Meier Estimate; Colorectal Neoplasms; Female; Disease-Free Survival; Humans; Quality of Life; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials Phase III as Topic; Aged; Adult; Health Status Indicators; Multicenter Studies as TopicFolinic acidQuality of lifeInternal medicineAntineoplastic Combined Chemotherapy Protocols80 and overmedicineOverall survivalHealth Status IndicatorsHumansMulticenter Studies as TopicClinical TrialsRadiology Nuclear Medicine and imagingneoplasmsmetastatic colorectal canceroxaliplatin physical functioning statusAgedRandomized Controlled Trials as TopicRetrospective StudiesAged 80 and overbusiness.industryHematologyGeneral MedicineMiddle AgedPrognosismedicine.diseaseSurgeryOxaliplatinPhase III as TopicTreatment OutcomeClinical Trials Phase III as TopicOncologyQuartileQuality of LifeFemaleColorectal Neoplasmsbusinessmedicine.drug
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Translation and Testing of the Italian Version of FAMCARE-2: Measuring Family Caregivers' Satisfaction With Palliative Care.

2017

Family satisfaction is an important outcome of palliative care and is a critical measure for health care professionals to address when assessing quality of care. The FAMCARE-2 is a widely used measure of family satisfaction with the health care received by both patient and family in palliative care. In this study, a team of Italian researchers culturally adapted the FAMCARE-2 to the Italian language and psychometrically tested the instrument by measuring satisfaction of 185 family caregivers of patients admitted into two palliative care services. FAMCARE-2 showed excellent levels of internal consistency (Cronbach’s α coefficient = .96) and test–retest reliability ( r = .98, p < .01). Th…

AdultMalemedicine.medical_specialtyPalliative carePsychometricsPsychometricspsychometricFamily satisfactionPersonal Satisfaction03 medical and health sciences0302 clinical medicineNursingCronbach's alphaSurveys and QuestionnairesHealth care80 and overmedicineHumansFamilyTranslations030212 general & internal medicinefamily caregiverAgedCommunity and Home CareAged 80 and overFamily caregiversbusiness.industryPalliative CareReproducibility of Resultssatisfaction with careMiddle AgedSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheConfirmatory factor analysisCaregiversItalyPatient Satisfaction030220 oncology & carcinogenesisScale (social sciences)Family medicinesurveys and questionnaireFemaleFamily Practicebusinessitalian translation; family caregivers; palliative care; psychometric development; satisfaction with care; adult; aged; aged 80 and over; caregivers; family; female; humans; italy; male; middle aged; palliative care; patient satisfaction; psychometrics; reproducibility of results; surveys and questionnaires; translations; personal satisfactionitalian translationpsychometric developmentJournal of family nursing
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Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study

2016

Background and Aims: Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer in IBD. The role of immunomodulators vs clinical characteristics of IBD as risk factors for cancer was also investigated. Materials and Methods: From January 2012 to December 2014, each IBD patient with incident cancer was matched with two IBD patients without cancer for: IBD type, gender, and age. Risk factors were assessed by multivariate regression analysis. Results: IBD patients considered numbered 44619: 21953 Crohn’s disease \[CD], 22666 ulcerative colitis [UC]. Cancer occurred in 174 patients…

AdultMalemedicine.medical_specialtyPancolitisAdolescentColorectal cancerphenotypeSettore MED/12 - GASTROENTEROLOGIAcancer riskInflammatory bowel disease; cancer risk; phenotype; Adolescent; Adult; Aged; Aged 80 and over; Case-Control Studies; Female; Follow-Up Studies; Humans; Immunologic Factors; Incidence; Inflammatory Bowel Diseases; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasms; Prospective Studies; Risk Factors; Young Adult; PhenotypeGastroenterologyInflammatory bowel diseaseInflammatory bowel disease03 medical and health sciencesYoung Adult0302 clinical medicineRisk FactorsInternal medicineNeoplasms80 and overmedicineHumansImmunologic FactorsProspective StudiesRisk factorProspective cohort studyAgedAged 80 and overbusiness.industryIncidenceSettore MED/09 - MEDICINA INTERNAGastroenterologyCancerGeneral MedicineMiddle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisLogistic Models030220 oncology & carcinogenesisCase-Control StudiesNested case-control studyMultivariate Analysis030211 gastroenterology & hepatologyFemalemedicine.symptombusinessInflammatory bowel disease; cancer risk; phenotypeFollow-Up Studies
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How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire.

2008

We used a CAPSIT-based questionnaire to estimate the percentage of parkinsonian patients suitable for subthalamic nucleus (STN) deep brain stimulation (DBS) in a movement disorders clinic. We found that out of 641 consecutive PD patients only 1.6% fulfilled strict STN-DBS criteria. When we applied more flexible criteria, the percentage of eligibility increased to 4.5%. Most patients (60%) were ineligible because they did not satisfy multiple questionnaire items. Items related to disease severity were responsible for the largest number of exclusions. This knowledge will help make decisions on resource allocation in centres wishing to start DBS surgery.

AdultMalemedicine.medical_specialtyParkinson's diseaseMovement disordersNeurologyDeep brain stimulationDeep Brain Stimulationmedicine.medical_treatmentParkinson Desease Deep Brain StimulationAudiologybehavioral disciplines and activitiesDisease severityParkinsonian DisordersSubthalamic NucleusSurveys and QuestionnairesmedicineHumansAgedChi-Square Distributionbusiness.industryPatient SelectionMiddle Agedmedicine.diseasenervous system diseasesSubthalamic nucleussurgical procedures operativenervous systemNeurologyCAPSIT; Parkinson's disease; Questionnaire; STN DBS; Adult; Aged; Chi-Square Distribution; Deep Brain Stimulation; Female; Humans; Male; Middle Aged; Parkinsonian Disorders; Subthalamic Nucleus; Surveys and Questionnaires; Patient Selection; Aging; Neurology (clinical); NeurologyPhysical therapyFemaleSettore MED/26 - NeurologiaNeurology (clinical)medicine.symptomGeriatrics and GerontologyPsychologybusinesstherapeuticsNeuroscienceNeurology; Geriatrics and Gerontology; Neurology (clinical)
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Oral self-injuries: clinical findings in a series of 19 patients

2015

Objectives: Self-injury (SI) is defined as a behavioral disturbance consisting of a deliberate harm to one’s own body without suicidal intent, it is not uncommon and ranges in severity from simple nail-biting to more extreme forms of self-mutilation. The head neck region may be the target of such lesions. SI is associated with several medical conditions, of which it can represent the first clinical sign. Aim of this paper is to describe a series of oral SI, giving special emphasis to the clinical findings, etiology and the management of lesions. Material and Methods: A total of 19 patients with oral SI were prospectively examined; attention was paid to the occurrence and characterization of…

AdultMalemedicine.medical_specialtyPediatricsAdolescentPoison controlOdontologíaDiseaseLesionYoung AdultInjury preventionmedicineHumansMedical historyAdolescent; Adult; Aged; Aged 80 and over; Child; Female; Humans; Male; Middle Aged; Mouth; Prospective Studies; Wounds and Injuries; Young Adult; Self-Injurious BehaviorProspective StudiesYoung adultProspective cohort studyChildGeneral DentistryAgedAged 80 and overMouthOral Medicine and Pathologybusiness.industryResearchWounds and InjurieMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgeryProspective StudieOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASEtiologyWounds and InjuriesSurgeryFemalemedicine.symptombusinessSelf-Injurious BehaviorHuman
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Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise

2010

J Appl Physiol. 2010 Jul;109(1):60-7. Epub 2010 May 6. Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise. Bonsignore MR, Morici G, Riccioni R, Huertas A, Petrucci E, Veca M, Mariani G, Bonanno A, Chimenti L, Gioia M, Palange P, Testa U. SourceBiomedical Department, Internal and Specialistic Medicine (DIBIMIS), Section of Pneumology, University of Palermo, Via Trabucco, 180, 90146 Palermo, Italy. marisa@ibim.cnr.it Abstract The effects of endurance or maximal exercise on mobilization of bone marrow-derived hemopoietic and angiogenetic progenitors in healthy subjects are poorly defined. In 10 healthy amateur runners, we collect…

AdultMalemedicine.medical_specialtyPhysiologyNeovascularization PhysiologicAntigens CD34Physical exerciseHematopoietic Cell Growth FactorsSettore BIO/09 - FisiologiaRunningangiopoietin; marathon; circulating progenitors; growth factorsAntigens CDEndurance trainingPhysiology (medical)Internal medicinegrowth factorsmedicineHumansAC133 AntigenProgenitor cellGlycoproteinsErythroid Precursor CellsbiologyAthletesbusiness.industryangiopoietinHealthy subjectsEndothelial Cellscirculating progenitorMiddle AgedCadherinsHematopoietic Stem Cellsbiology.organism_classificationHaematopoiesisEndocrinologyAthletesPhysical EnduranceCytokinesAngiogenesis Inducing Agentsadult; angiogenesis inducing agents; angiopoietin; antigens; athletes; blood; cadherins; cd; cd34; circulating progenitors; cytokines; endothelial cells; erythroid precursor cells; glycoproteins; granulocytes; growth factors; hematopoietic cell growth factors; hematopoietic stem cells; humans; male; marathon; middle aged; neovascularization; peptides; physical endurance; physiologic; physiology; runningAC133 antigenMaximal exercisemarathonPeptidesbusinessGranulocytesJournal of Applied Physiology
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Cervical Spondylotic Myelopathy: When and Why the Cervical Corpectomy?

2020

Background: Cervical spondylotic myelopathy (CSM) is a degenerative disease that represents the most common spinal cord disorder in adults. The best treatment option has remained controversial. We performed a prospective study to evaluate the clinical, radiographic, and neurophysiologic outcomes for anterior cervical corpectomy in the treatment of CSM. Methods: From January 2011 to January 2017, 60 patients with CSM were prospectively enrolled in the present study. The patients were divided according to the modified Japanese Orthopaedic Association scale (mJOA) score into 2 groups: group A, patients with mild to moderate CSM (mJOA score ≥13); and group B, patients with severe myelopathy (mJ…

AdultMalemedicine.medical_specialtyRadiographymedicine.medical_treatmentSpinal Cord DisorderIntervertebral Disc DegenerationOssification of Posterior Longitudinal LigamentSeverity of Illness IndexMyelopathyYoung AdultDegenerative diseaseSpondylotic myelopathySymptom durationMedicineHumansProspective StudiesCorpectomyProspective cohort studyCervical corpectomy Young Adult Cervical spondylotic myelopathy Degenerative cervical myelopathy Surgical outcomes Adult Aged Cervical Vertebrae Decompression Surgical Functional Status Intervertebral Disc Degeneration Female Intervertebral Disc Displacement Humans Ossification of Posterior Longitudinal Ligament Middle Aged Male Prospective Studies Spinal Cord Compression Severity of Illness Index Treatment Outcome Spinal Fusion SpondylosisAgedbusiness.industryMiddle Agedmedicine.diseaseDecompression SurgicalSurgeryFunctional StatusSpinal FusionTreatment OutcomeCervical VertebraeSurgeryFemaleNeurology (clinical)SpondylosisbusinessSpinal Cord CompressionIntervertebral Disc DisplacementWorld neurosurgery
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The Severe Asthma Network in Italy: Findings and Perspectives

2019

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by accredited centers on severe asthma. Objective To analyze epidemiological, clinical, inflammatory, functional, and treatment characteristics of severe asthmatics from the SANI registry. Methods All consecutive patients with severe asthma were included into the registry, without exclusion criteria to have real-life data on demographics, asthma control, treatments (including biologics), inflammatory biomarkers, and comorbidities. Results A total of 437 patients (mean age: 54.1 years, 57.2% females, 70.7% atopics, 94.5% in Global Initiative for Asthma severity step V) were enrolled into the study. The mean …

AdultMalemedicine.medical_specialtyRegistrySevere asthmaExacerbationBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Immunology and AllergyOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioComorbiditiesAtopy03 medical and health sciencesBronchiectasi0302 clinical medicineFood allergyInternal medicineLate-onset asthmaNasal polypsBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Adult; Aged; Asthma; Bronchiectasis; Comorbidity; Eosinophils; Female; Humans; Immunoglobulin E; Italy; Male; Middle Aged; Nasal Polyps; Registries; RhinitisMedicineHumansBronchiectasis Comorbidities Late-onset asthma Nasal polyps Registry SANI Severe asthma Immunology and AllergyImmunology and Allergy030212 general & internal medicineRegistriesAsthmaAgedRhinitisBronchiectasisbusiness.industryNasal polypSANIImmunoglobulin EMiddle Agedmedicine.diseaseAsthmaBronchiectasisEosinophils030228 respiratory systemItalyAsthma Control QuestionnaireFemaleComorbiditiebusinessMepolizumabmedicine.drug
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RhinAsthma patient perspective: a short daily asthma and rhinitis QoL assessment.

2012

Background The present study aimed to develop a short validated patient-completed questionnaire, the RhinAsthma Patient Perspective (RAPP), to assess the health-related quality of life (HRQoL) in patients with asthma and comorbid allergic rhinitis in clinical practice. Methods A provisional RAPP questionnaire was formed from candidate items identified through retrospective analysis of 333 RHINASTHMA questionnaires. This was then tested on 150 asthma patients with allergic rhinitis. Results Psychometric analyses identified eight items fitting a unidimensional model to form RAPP. Internal consistency (Cronbach's alpha coefficient > 0.8) and agreement with RHINASTHMA (r = −0.31, P = 0.0001) we…

AdultMalemedicine.medical_specialtyRhinitis Allergic PerennialPsychometricsAdolescentPsychometricsVisual analogue scaleassessmentConcordanceImmunologyPopulationSettore MED/10 - Malattie Dell'Apparato RespiratoriorhinitisAllergicCronbach's alphaQuality of lifeSurveys and Questionnaires80 and overmedicineSurveys and QuestionnaireImmunology and AllergyHumansdaily practiceeducationAsthmaAgedAged 80 and overeducation.field_of_studybusiness.industryassessment; asthma; daily practice; quality of life; rhinitis; Adolescent; Adult; Aged; Aged 80 and over; Asthma; Female; Humans; Male; Middle Aged; Psychometrics; Rhinitis Allergic; Rhinitis Allergic Perennial; Quality of Life; Surveys and Questionnaires; Immunology and Allergy; ImmunologyMiddle Agedmedicine.diseasePerennialRhinitis AllergichumanitiesAsthmarhinitiConvergent validityassessment; asthma; daily practice; quality of life; rhinitisPhysical therapyQuality of LifeFemalebusinessPsychometricHumanAllergy
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