Search results for " Middle"

showing 10 items of 1097 documents

Assessment of maximal handgrip strength: How many attempts are needed?

2017

BACKGROUND: Handgrip strength (HGS) is used to identify individuals with low muscle strength (dynapenia). The influence of the number of attempts on maximal HGS is not yet known and may differ depending on age and health status. This study aimed to assess how many attempts of HGS are required to obtain maximal HGS.METHODS: Three cohorts (939 individuals) differing in age and health status were included. HGS was assessed three times and explored as continuous and dichotomous variable. Paired t-test, intraclass correlation coefficients (ICC) and Bland-Altman analysis were used to test reproducibility of HGS. The number of individuals with misclassified dynapenia at attempts 1 and 2 with respe…

AdultSarcopeniaAdolescentsex differenceHealth Statusadult; aged; aging; Article; cohort analysis; dual energy X ray absorptiometry; dynamometer; female; four minute walk test; geriatric assessment; grip strength; health status; human; major clinical study; male; middle aged; muscle strength; outpatient; priority journal; reproducibility; sarcopenia; sex difference; six minute walk test; walk test; walking speed; X ray bone densitometer; Aged; Geriatric assessment; Muscle strength; Reproducibility of Results; Sarcopeniahealth statuswalking speedArticlesarcopeniaCohort StudiesYoung Adultmalesix minute walk testmiddle aged80 and overHumansfour minute walk testhumanMuscle StrengthreproducibilityGeriatric AssessmentX ray bone densitometerAgedAged 80 and overdual energy X ray absorptiometryHand StrengthMuscle strengthadultwalk testagingAge FactorsReproducibility of ResultsOriginal ArticlesdynamometerMiddle Agedcohort analysismajor clinical studyGeriatric assessmentfemaleCross-Sectional Studiespriority journalgrip strengthoutpatientOriginal Articlelihasvoima
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The 2014 lifetime immunization schedule approved by the Italian scientific societies. Italian Society of Hygiene, Preventive Medicine, and Public Hea…

2014

AdultSecondaryAdolescentAdolescent; Adult; Age Factors; Aged; Child; Child Preschool; Humans; Immunization Secondary; Infant; Infant Newborn; Italy; Middle Aged; Societies Medical; Vaccination; Vaccines; Young Adult; Immunization ScheduleImmunization SecondaryYoung AdultMedicalHumansAge FactorPreschoolChildImmunization ScheduleSocieties MedicalAgedVaccinesVaccinationAge FactorsInfant NewbornInfantMiddle AgedNewbornSettore MED/38ItalyChild PreschoolImmunizationSocietiesVaccineHuman
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Social distancing in chronic migraine during the covid-19 outbreak: Results from a multicenter observational study

2021

Background: The restrictions taken to control the rapid spread of COVID-19 resulted in a sudden, unprecedented change in people’s lifestyle, leading to negative consequences on general health. This study aimed to estimate the impact of such changes on migraine severity during 2020 March–May lockdown. Methods: Patients affected by migraine with or without aura, diagnosed by expert physicians, completed a detailed interview comprehensive of: assessment of migraine characteristics

AdultSleep Wake Disordersmedicine.medical_specialtyAuraMigraine DisordersPhysical DistancingMetabolic equivalentArticle03 medical and health sciences0302 clinical medicineChronic MigraineQuality of lifeInternal medicineSurveys and QuestionnairesEpidemiologymedicineHumansTX341-641030212 general & internal medicineExerciseLife StyleMigraineNutritionSleep disorderSleep disorderNutrition and DieteticsCOVID-19; Migraine; Nutrition; Physical activity; Quarantine; Sleep disorder; Adult; COVID-19; Communicable Disease Control; Exercise; Feeding Behavior; Headache; Humans; Italy; Life Style; Middle Aged; Migraine Disorders; Quality of Life; Quarantine; SARS-CoV-2; Sleep; Sleep Wake Disorders; Surveys and Questionnaires; Physical Distancingbusiness.industryNutrition. Foods and food supplyPhysical activitySARS-CoV-2HeadacheCOVID-19Feeding BehaviorMiddle Agedmedicine.diseaseMigraineItalyQuarantineCommunicable Disease ControlQuality of LifeObservational studySettore MED/26 - Neurologiasense organsbusinessSleep030217 neurology & neurosurgeryFood Science
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Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St G…

2009

Background: Defining risk categories in breast cancer is of considerable clinical significance. We have developed a novel risk classification algorithm and compared its prognostic utility to the Web-based tool Adjuvant! and to the St Gallen risk classification. Patients and methods: After a median follow-up of 10 years, we retrospectively analyzed 410 consecutive node-negative breast cancer patients who had not received adjuvant systemic therapy. High risk was defined by any of the following criteria: (i) age 2 cm. All patients were also characterized using Adjuvant! and the St Gallen 2007 risk categories. We analyzed disease-free survival (DFS) and overall survival (OS). Results: The Node-…

AdultTime FactorsBreast NeoplasmsKaplan-Meier EstimateRisk AssessmentSensitivity and SpecificityDisease-Free SurvivalBreast cancerBreast cancer 3Predictive Value of TestsMedicineHumansLongitudinal StudiesProspective StudiesRisk factorAgedNeoplasm StagingRetrospective StudiesAged 80 and overNeovascularization Pathologicbusiness.industryHazard ratioCancerRetrospective cohort studyHematologyGenes erbB-2Middle Agedmedicine.diseasePrognosisImmunohistochemistrySurvival AnalysisTreatment OutcomeOncologyAdult; Aged; Aged 80 and over; Algorithms; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Breast Neoplasms/radiotherapy; Breast Neoplasms/surgery; Disease-Free Survival; Female; Follow-Up Studies; Genes erbB-2; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Longitudinal Studies; Middle Aged; Multivariate Analysis; Neoplasm Staging; Neovascularization Pathologic; Predictive Value of Tests; Prognosis; Prospective Studies; Receptors Progesterone/analysis; Regression Analysis; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Time Factors; Treatment OutcomeMultivariate AnalysisRegression AnalysisFemaleBreast diseasebusinessRisk assessmentReceptors ProgesteroneAlgorithmAlgorithmsFollow-Up Studies
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Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, …

2012

The objective of the study was to compare the efficacy and safety of frovatriptan and almotriptan in women with menstrually related migraine (IHS Classification of Headache disorders) enrolled in a multicenter, randomized, double-blind, cross-over study. Patients received frovatriptan 2.5 mg or almotriptan 12.5 mg in a randomized sequence: after treating 3 episodes of migraine in no more than 3 months with the first treatment, the patient was switched to the other treatment. 67 of the 96 female patients of the intention-to-treat population of the main study had regular menstrual cycles and were thus included in this subgroup analysis. 77 migraine attacks classified as related to menses were…

AdultTime FactorsOriginalMigraine DisordersPopulationAlmotriptanClinical NeurologyCarbazolesSubgroup analysisSeverity of Illness IndexAdult; Carbazoles; Cross-Over Studies; Disability Evaluation; Double-Blind Method; Female; Humans; Italy; Menstruation Disturbances; Middle Aged; Migraine Disorders; Proportional Hazards Models; Serotonin Receptor Agonists; Severity of Illness Index; Time Factors; Treatment Outcome; TryptaminesDisability EvaluationDouble-Blind MethodAlmotriptanSeverity of illnessMedicineHumanseducationMigraine Menstrually related migraine Frovatriptan AlmotriptanMenstrually related migraineMenstruation DisturbancesMigraineMenstrually related migraineProportional Hazards Modelseducation.field_of_studyCross-Over Studiesbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseCrossover studyTryptaminesSerotonin Receptor Agonistsfrovatriptan; migraine; menstrually related migraine; almotriptanAnesthesiology and Pain MedicineTreatment OutcomeMigraineItalyAnesthesiaFemaleNeurology (clinical)businessFrovatriptanFrovatriptanmedicine.drug
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Laparoscopic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

2015

Abstract Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Federation Internationale de Gynecologie et d'Obstetrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The …

AdultUterine Cervical Neoplasmmedicine.medical_specialtymedicine.medical_treatmentUterine Cervical NeoplasmsHysterectomyPostoperative ComplicationsmedicineRadical hysterectomyHumansProspective StudiesCervical cancer; Laparoscopy; Neoadiuvant chemoradiation; Radical hysterectomy; Adult; Aged; Carcinoma; Squamous Cell; Chemoradiotherapy; Adjuvant; Cisplatin; Feasibility Studies; Female; Humans; Italy; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence; Local; Postoperative Complications; Prospective Studies; Uterine Cervical Neoplasms; Hysterectomy; Laparoscopy; Lymph Node ExcisionRadical surgeryRadical HysterectomyProspective cohort studyNeoadjuvant therapyAgedCervical cancerHysterectomybusiness.industryMedicine (all)Obstetrics and GynecologyLaparoscopic Radical HysterectomyPerioperativeChemoradiotherapy AdjuvantMiddle Agedmedicine.diseaseNeoadjuvant TherapySurgeryFeasibility StudieProspective StudieSettore MED/40 - GINECOLOGIA E OSTETRICIAItalyCervical cancerNeoadiuvant chemoradiationCarcinoma Squamous CellFeasibility StudiesLymph Node ExcisionLymphadenectomyFemaleLaparoscopyPostoperative ComplicationCisplatinNeoplasm Recurrence LocalbusinessHuman
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Cancers in Patients with von Willebrand Disease: A Survey from the Italian Association of Haemophilia Centres

2015

Besides its essential role in hemostasis, there is growing evidence that von Willebrand factor (VWF) has an additional antitumor effect. To elucidate the clinical significance of this biological activity we conducted a retrospective study on cancers among Italian patients with von Willebrand disease (VWD) on behalf of the Italian Association of Haemophilia Centres (AICE). A questionnaire to collect demographic, clinical, and treatment data of VWD patients with cancer was sent to all the 54 Italian Haemophilia Treatment Centres (HTCs) members of AICE. Overall, 18 HTCs (33%) provided information on 92 VWD patients (61 alive and 31 deceased) with 106 cancers collected during the period 1981 to…

Adultcongenital hereditary and neonatal diseases and abnormalitiesPediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaPopulationbleeding; cancer; mortality; von Willebrand disease; Hematology; Cardiology and Cardiovascular MedicineHaemophiliaHospitals Specialbleeding; cancer; mortality; von Willebrand disease; Adult; Aged; Aged 80 and over; Humans; Italy; Middle Aged; Prospective Studies; Hospitals Special; Neoplasms; Surveys and Questionnaires; von Willebrand Diseases; Hematology; Cardiology and Cardiovascular MedicineVon Willebrand factorNeoplasmsSurveys and Questionnaireshemic and lymphatic diseases80 and overmedicineVon Willebrand diseaseHumanscancerProspective StudiesDesmopressinProspective cohort studyeducationAgedAged 80 and overeducation.field_of_studySpecialbiologybusiness.industryRetrospective cohort studyHematologyMiddle Agedmedicine.diseasebleedingmortalityHospitalsbleeding; cancer; mortality; von Willebrand disease; Adult; Aged; Aged 80 and over; Humans; Italy; Middle Aged; Prospective Studies; Hospitals Special; Neoplasms; Surveys and Questionnaires; von Willebrand Diseasesvon Willebrand DiseasesItalyHemostasisbiology.proteinbusinessvon Willebrand diseaseCardiology and Cardiovascular Medicinemedicine.drug
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Isolated Endometriosis on the Rectus Abdominis Muscle in Women without a History of Abdominal Surgery: a Rare and Intriguing Finding

2009

We report 2 rare cases of endometriosis on the rectus abdominal muscle diagnosed incidentally during an operation for inguinal hernia repair in women with no surgical history. Two women sought medical attention for a mass found in the pubic abdominal wall. Only 1 woman reported occasional pain. At physical examination in both women, an ovoid swelling in the right pubic area was felt. One woman experienced pain on palpation, and one reported slight discomfort. Ultrasonography demonstrated a heterogeneous hypoechogenic formation with indistinct edges; diagnosis was difficult. Routine clinical and instrumental (pelvic ultrasonography) gynecologic examination in both patients performed shortly …

Adultmedicine.medical_specialtyAbdominal painAbdominal painRectus abdominal muscle endometriosisHerniaEndometriosisRectus AbdominisEndometriosisHernia InguinalAbdominal wall endometriosisPalpationAbdominal pain; Abdominal wall endometriosis; Rectus abdominal muscle endometriosis; Adult; Endometriosis; Female; Hernia Inguinal; Humans; Incidental Findings; Middle Aged; Rectus Abdominis; Ultrasonography; Diagnostic ErrorsAbdominal wallmedicineHumansDiagnostic ErrorsRectus abdominis musclePelvisUltrasonographyIncidental Findingsmedicine.diagnostic_testbusiness.industryObstetrics and GynecologyMiddle Agedmedicine.diseaseAbdominal wall endometriosiSettore MED/40 - Ginecologia E OstetriciaSurgeryInguinal herniamedicine.anatomical_structureabdominal pain; abdominal wall endometriosis; rectus abdominal muscle endometriosisInguinalFemalemedicine.symptombusinessAbdominal surgery
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Laparoscopic staging of apparent early stage ovarian cancer: Results of a large, retrospective, multi-institutional series

2014

Abstract Objective The aim of this study is to analyze the safety, adequacy, perioperative and survival figures in a large series of laparoscopic staging of patients with apparent early stage ovarian malignancies (ESOM). Patients and methods Retrospective data from seven gynecologic oncology service databases were searched for ESOM patients undergoing immediate laparoscopic staging or delayed laparoscopic staging after an incidental diagnosis of ESOM. Between May 2000 and February 2014, 300 patients were selected: 150 had been submitted to immediate laparoscopic staging (Group 1), while 150 had undergone delayed laparoscopic staging (Group 2) of ESOM. All surgical, pathologic, and oncologic…

Adultmedicine.medical_specialtyAdolescentmedicine.medical_treatmentGynecologic oncologyYoung AdultEarly ovarian cancer; Laparoscopy; Ovarian cancer; Adolescent; Adult; Aged; Aged; 80 and over; Child; Female; Humans; Laparoscopy; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Retrospective Studies; Young AdultOvarian cancerLaparotomymedicine80 and overHumansEarly ovarian cancer; Laparoscopy; Ovarian cancer; Adolescent; Adult; Aged; Aged 80 and over; Child; Female; Humans; Laparoscopy; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Retrospective Studies; Young AdultStage (cooking)LaparoscopyChildAgedNeoplasm StagingRetrospective StudiesAged 80 and overOvarian Neoplasmsmedicine.diagnostic_testbusiness.industryOvarian cancer Early ovarian cancer LaparoscopyMedicine (all)Obstetrics and GynecologyRetrospective cohort studyPerioperativeMiddle Agedmedicine.diseasePrognosisSurgerySerous fluidSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologyEarly ovarian cancerFemaleLaparoscopybusinessOvarian cancer
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PML risk is the main factor driving the choice of discontinuing natalizumab in a large multiple sclerosis population: results from an Italian multice…

2021

none 38 no BACKGROUND: Natalizumab (NTZ) is an effective treatment for relapsing-remitting multiple sclerosis (RRMS). However, patients and physicians may consider discontinuing NTZ therapy due to safety or efficacy issues. The aim of our study was to evaluate the NTZ discontinuation rate and reasons of discontinuation in a large Italian population of RRMS patients. MATERIALS AND METHODS: The data were extracted from the Italian MS registry in May 2018 and were collected from 51,845 patients in 69 Italian multiple sclerosis centers. MS patients with at least one NTZ infusion in the period between June 1st 2012 to May 15th 2018 were included. Discontinuation rates at each time point were cal…

Adultmedicine.medical_specialtyDiscontinuation rateNeurologyReasons for discontinuationPopulationProgressive MultifocalRelapsing-RemittingSettore MED/26Multiple sclerosis03 medical and health sciences0302 clinical medicineNatalizumabMultiple Sclerosis Relapsing-RemittingLeukoencephalopathyInternal medicineparasitic diseasesmedicineEffective treatmentHumansImmunologic FactorsMultiple sclerosi030212 general & internal medicineeducationRetrospective Studieseducation.field_of_studyDiscontinuation rate; Multiple sclerosis; Natalizumab; Reasons for discontinuation; Adult; Female; Humans; Immunologic Factors; Middle Aged; Natalizumab; Retrospective Studies; Leukoencephalopathy Progressive Multifocal; Multiple Sclerosis; Multiple Sclerosis Relapsing-Remittingbusiness.industryMultiple sclerosisProgressive multifocal leukoencephalopathyNatalizumabLeukoencephalopathy Progressive MultifocalRetrospective cohort studyMiddle Agedmedicine.diseaseDiscontinuationNeurologySettore MED/26 - NeurologiaFemaleNeurology (clinical)business030217 neurology & neurosurgerymedicine.drug
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