Search results for " Middle"
showing 10 items of 1097 documents
Outcomes of aortic valve repair according to valve morphology and surgical techniques
2012
OBJECTIVES: The aim of this study was to assess the impact of aortic valve morphology and different surgical aortic valve repair techni- ques on long-term clinical outcomes. METHODS: Between February 2003 and May 2010, 216 patients with aortic insufficiency underwent aortic valve repair in our institu- tion. Ages ranged between 26 and 82 years (mean 53 ± 15 years). Aortic valve dysfunctions, according to functional classification, were: type I in 55 patients (25.5%), type II in 126 (58.3%) and type III in 35 (16.2%). Sixty-six patients (27.7%) had a bicuspid valve. Aortic valve repair techniques included sub-commissural plasty in 138 patients, plication in 84, free-edge reinforcement in 80,…
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
2004
BACKGROUND: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. OBJECTIVE: To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. METHODS: Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognit…
Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.
2014
Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …
Early Bronze Age painted wares from Tell el-'Abd, Syria: A compositional and technological study
2018
Abstract The ‘Euphrates Monochrome Painted Ware’ (henceforth EMPW) is a ceramic style attested in the Middle Euphrates region in northern Syria at the beginning of the Early Bronze Age, ca. 2900–2700 BCE. This style is not an isolated phenomenon; rather, it must be understood in the context of a general, albeit short-lived, re-introduction of painted ceramics into local assemblages of Greater Mesopotamia. In the present study, we investigate the technology and provenance of the painted pottery from Tell el-'Abd (North Syria) and its relation to contemporary ceramics retrieved at this site. We apply a combination of macroscopic observations, ceramic petrography, and micro X-ray diffraction (…
Multi-analytical study of the medieval wall paintings from the rupestrian church Grotta del Crocifisso at Lentini (eastern Sicily): new evidence of t…
2022
AbstractThis study presents the results of the examination and characterisation of the wall paintings that decorate the rupestrian church named Grotta del Crocifisso, which is located in the territory of Lentini (eastern Sicily, few tens of kilometres from Catania and Syracuse). The earliest mural paintings in the church date back to the twelfth century AD. A multi-analytical approach was adopted for the characterisation of stone materials, secondary degradation products, and pigments. For this purpose, the following techniques were used: reflected light microscopy (RLM), polarised light microscopy on thin sections (PLM), X-ray powder diffraction (XRPD), mercury intrusion porosimetry (MIP),…
Prefazione a: Istituzioni ecclesiastiche e potere regio nel Mediterraneo medievale : Scritti per Salvatore Fodale
2016
Si esamina la produzione scientifica di Salvatore Fodale, basata sullo studio di documenti inediti custoditi in archivi italiani e spagnoli. Lo studioso ha posto al centro della sua ricerca i rapporti tra potere ecclesiastico e potere politico dall’età normanna al Quattrocento, nelle sue molteplici sfaccettature, dedicando ampio spazio allo Scisma d’Occidente e agli ordini religiosi. L’orizzonte geografico delle sue ricerche ha spaziato nel contesto mediterraneo, includendo la Sicilia, la Sardegna, l’Aragona, la Grecia e il Maghreb. We analyze the scientific production of Salvatore Fodale, based on the study of unpublished documents kept in in Italian and Spanish archives. The scholar has f…
TP53 codon 72 polymorphism and cervical cancer
2009
Background Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer.Methods Individual data on 7946 cases and 7888 controls from 49 different st…
Presence of Naraoia Walcott, 1912 in the middle Cambrian of Europe (Murero, NE Spain).
2018
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: http://sepaleontologia.es/revista/anteriores/SJP%20(2018)%20vol.%2033/vol.%201/04.pdf The genus Naraoia Walcott, 1912, a Burgess Shale-type fossil known from the lower and middle Cambrian of British Columbia (Canada), Idaho and Utah (USA), as well as from Yunnan and Guizhou provinces (China), is now reported from the middle Cambrian of Murero (Zaragoza, Spain), which is the first record in the Acadobaltic province. The only fragmented specimen found is determined as Naraoia sp., its age being Pardailhania multispinosa Zone (Drumian Stage). This new datum reinforces the hypothesis of the existence of a …
Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia
2004
Oxygen free radicals have been involved in the pathophysiology of cerebral ischemia, especially after spontaneous or thrombolytic reperfusion. In this study with rats, we have combined a severe focal ischemic insult (2 h) and a prolonged reperfusion time (7 days) to assess the possible sustained neuroprotective effect of ebselen (10 or 100 mg/kg), a small, lipophilic organoselenium compound which mimics glutathione peroxidase. Parietal cortical perfusion was measured by laser-Doppler flowmetry, and focal cerebral ischemia was carried out by the intraluminal thread method. We have measured plasma selenium levels, brain reduced glutathione levels, as a marker of oxidative stress, and infarct …
Novel M. tuberculosis specific IL-2 ELISpot assay discriminates adult patients with active or latent tuberculosis
2018
Background Tuberculosis (TB) still is a major worldwide health problem, with 10.4 million new cases in 2016. Only 5–15% of people infected with M. tuberculosis develop TB disease while others remain latently infected (LTBI) during their lifetime. Thus, the absence of tests able to distinguish between latent infection and active tuberculosis is one of the major limits of currently available diagnostic tools. Methods A total of 215 patients were included in the study as active TB cases (n = 73), LTBI subjects (n = 88) and healthy persons (n = 54). Peripheral blood mononuclear cells (PBMCs) were isolated from each patient and the LIOSpot® TB anti-human IL-2 ELISpot assay was performed to test …