Search results for " Middle"

showing 10 items of 1097 documents

Tapentadol in cancer pain management: a prospective open-label study.

2012

OBJECTIVES: The aim of this prospective, open-label study was to evaluate the efficacy and tolerability of tapentadol (TP) in the management of cancer pain. METHODS: A 4 weeks' prospective study was carried out in 50 opioid-naive cancer patients with moderate-severe pain. Each patient initially received twice-daily doses of slow-release TP 50 mg. Doses were then managed to maintain adequate relief or dose-limiting toxicity, on the basis of the clinical response. The following parameters were recorded at weekly intervals for 4 weeks: pain and opioid-related adverse effects, quality of life measured with the Spitzer score, TP escalation index percent (TPEI%) and TP escalation index in mg (TPE…

MaleSettore MED/41 - AnestesiologiaPainNeuropathic painCancer pain Neuropathic pain Opioids Tapentadol AnalgesiaQuality of lifePhenolsNeoplasmsMedicineCancer pain; Neuropathic pain; Opioids; Tapentadol; Aged; Analgesics; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Phenols; Prospective Studies; Medicine (all)HumansProspective StudiesCancer painAdverse effectProspective cohort studyAgedPain MeasurementAnalgesicsbusiness.industryMedicine (all)General MedicineMiddle AgedTapentadolClinical trialOpioidsTapentadolTolerabilityAnesthesiaNeuropathic painFemaleCancer painbusinessmedicine.drugCurrent medical research and opinion
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Pain Perception and Stabilometric Parameters in People With Chronic Low Back Pain After a Pilates Exercise Program

2016

Various exercise interventions, such as Pilates exercises and traditional physical therapy methods, are employed to decrease low back pain (LBP). Nonspecific low back pain (NSLBP) is distinct from LBP, however, as the distribution of pain is restricted to the region between the costal margin and the inferior gluteal. The aim of our randomized controlled trial was to evaluate the effects of a program of Pilates exercises on pain perception and stabilometric parameters in patients with NSLBP. Thirty-eight participants were randomly allocated, using a 1:1 scheme, to either the experimental group (EG) or control group (CG). The EG completed a 14-week program of Pilates exercises, performed thri…

MaleSeverity of Illness Indexlaw.inventionDisability Evaluation0302 clinical medicineRandomized controlled triallawProspective Studies030212 general & internal medicineProspective cohort studyPain MeasurementMedicine (all)StatisticsChronic painPain PerceptionGeneral MedicineMiddle AgedPrognosisLow back painOswestry Disability IndexTreatment OutcomePatient SatisfactionExercise Movement TechniquesFemaleChronic Painmedicine.symptomExercise Movement TechniqueSettore M-EDF/01 - Metodi E Didattiche Delle Attivita' MotorieHumanAdultmedicine.medical_specialtyPrognosiStatistics Nonparametric03 medical and health sciencesPatient satisfactionPhysical medicine and rehabilitationSeverity of illnessmedicineHumansAdult; Chronic Pain; Exercise Movement Techniques; Female; Humans; Low Back Pain; Male; Middle Aged; Pain Measurement; Pain Perception; Patient Satisfaction; Prognosis; Prospective Studies; Severity of Illness Index; Statistics Nonparametric; Treatment Outcome; Disability Evaluation; Medicine (all)NonparametricSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' Sportivebusiness.industryPosturographymedicine.diseaseProspective StudiePhysical therapybusinessLow Back Pain030217 neurology & neurosurgeryMedicine
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The GENDER ATTENTION Observational Study: Gender and Hormonal Status Differences in the Incidence of Adverse Events During Cyclosporine Treatment in …

2017

Introduction: Female sex has been shown to be a risk factor for the development of adverse drug reactions; however, this has not been studied for cyclosporine (CsA). The aim of this study was to investigate, in Italian dermatological practice, the influence of gender and menopause and related hormones on the incidence of adverse events (AEs) during CsA treatment in psoriatic patients. Methods: Multicenter, prospective, observational study conducted from May 2011 to June 2013. Patients with plaque psoriasis, undergoing a new CsA administration course, or about to start it, were enrolled in the outpatient clinics of Italian dermatological centers. During the 2–6 months of study duration, pati…

MaleSex FactorRate ratio030226 pharmacology & pharmacyGonadal Steroid HormoneSeverity of Illness Index0302 clinical medicineOutpatient clinicAdverse drug reaction; Cyclosporine; Dermatology; Female; Gender; PsoriasisPharmacology (medical)030212 general & internal medicineProspective StudiesProspective cohort studyGonadal Steroid HormonesOriginal ResearchIncidence (epidemiology)IncidenceMedicine (all)General MedicineMiddle AgedMenopausePostmenopauseItalyCyclosporineFemaleSettore MED/35 - MALATTIE CUTANEE E VENEREEHumanAdultmedicine.medical_specialtyAdolescentAdverse drug reaction; Cyclosporine; Dermatology; Female; Gender; Psoriasis; Adolescent; Adult; Cyclosporine; Female; Gonadal Steroid Hormones; Humans; Incidence; Italy; Male; Middle Aged; Postmenopause; Prospective Studies; Psoriasis; Severity of Illness Index; Sex Factors; Young Adult; Pharmacology (medical)Adverse drug reactionDermatology03 medical and health sciencesYoung AdultSex FactorsInternal medicineSeverity of illnessmedicineHumansPsoriasisRisk factorAdverse effectPsoriasibusiness.industryGendermedicine.diseaseSurgeryAdverse drug reaction; Cyclosporine; Dermatology; Female; Gender; Psoriasis; Medicine (all); Pharmacology (medical)Prospective StudiebusinessAdverse drug reaction; Cyclosporine; Dermatology; Female; Gender; Psoriasis;
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Sleep problems and subjective cognitive complaints among middle-aged and older adults in 45 low- and middle-income countries

2022

Background: Currently, a small body of evidence suggests that sleep problems are positively associated with subjective cognitive complaints (SCC). However, no studies on this topic exist from low- and middle-income countries (LMICs). Thus, we investigated the association between sleep problems and SCC in a large sample of middle-age and older adults from 45 LMICs. Methods: Cross-sectional, predominantly nationally representative, community-based data were analyzed from the World Health Survey. Sleep problems (such as difficulties falling asleep, waking up frequently during the night or waking up too early in the morning) in the last 30 days were self-reported. Two questions on subjective me…

MaleSleep Wake DisordersAgingSmith L. Oh H. Jacob L. López-Sánchez G. F. Veronese N. Soysal P. Shin J. I. Schuch F. Tully M. A. Butler L. et al. -Sleep problems and subjective cognitive complaints among middle-aged and older adults in 45 low- and middle-income countries.- Aging clinical and experimental research 2022Middle AgedSleep problems · Subjective cognitive complaints · Low- and middle-income countries · Older adultsCognitionCross-Sectional StudiesPrevalenceHumansFemaleGeriatrics and GerontologyDeveloping CountriesAged
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"I Know that You Know that I Know": Neural Substrates Associated with Social Cognition Deficits in DM1 Patients.

2016

Myotonic dystrophy type-1 (DM1) is a genetic multi-systemic disorder involving several organs including the brain. Despite the heterogeneity of this condition, some patients with non-congenital DM1 can present with minimal cognitive impairment on formal testing but with severe difficulties in daily-living activities including social interactions. One explanation for this paradoxical mismatch can be found in patients' dysfunctional social cognition, which can be assessed in the framework of the Theory of Mind (ToM). We hypothesize here that specific disease driven abnormalities in DM1 brains may result in ToM impairments. We recruited 20 DM1 patients who underwent the "Reading the Mind in th…

MaleSocial CognitionMagnetic Resonance SpectroscopyTheory of MindAdult; Brain; Cognition; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myotonic Dystrophy; Neuropsychological Tests; Social Behavior; Theory of MindSocial Scienceslcsh:MedicineDiseaseNeuropsychological TestsDiagnostic RadiologyCognition0302 clinical medicineFunctional Magnetic Resonance ImagingTheory of mindMedicine and Health SciencesPsychologyMyotonic Dystrophylcsh:ScienceCognitive ImpairmentBrain MappingMultidisciplinarymedicine.diagnostic_testCognitive NeurologyRadiology and Imagingagricultural and biological sciences (all); biochemistry genetics and molecular biology (all); medicine (all)05 social sciencesRBrainCognitionMiddle AgedMagnetic Resonance ImagingNeurologyRC0346Genetic DiseasesPhysical SciencesFemaleSettore MED/26 - NeurologiaPsychologyResearch ArticleClinical psychologyAdultmusculoskeletal diseasesComputer and Information Sciencesmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesSocial PsychologyImaging TechniquesCognitive NeuroscienceNeuroimagingDysfunctional familyResearch and Analysis MethodsMyotonic dystrophy050105 experimental psychology03 medical and health sciencesDiagnostic MedicineSocial cognitionTheory of mind cerebral lesionGeneticsmedicineHumans0501 psychology and cognitive sciencesSocial BehaviorPsychiatryClinical GeneticsSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicalcsh:RCognitive PsychologyBiology and Life SciencesHuman Geneticsmedicine.diseaseComprehensionGraph TheoryRC0321Cognitive Sciencelcsh:QFunctional magnetic resonance imagingMathematics030217 neurology & neurosurgeryNeurosciencePLoS ONE
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Fluid challenges in intensive care: the FENICE study: a global inception cohort study

2015

Background: Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC. Methods: This was an observational study conducted i…

MaleSoins intensifs réanimationmedicine.medical_treatmentCohort Studies; Female; Humans; Male; Middle Aged; Practice Patterns Physicians'; Critical Care; Fluid Therapy; Critical Care and Intensive Care MedicinePractice PatternsESICM Trial GroupCritical Care and Intensive Care MedicineRESPONSIVENESSCohort StudiesSeven-Day Profile PublicationMedicine and Health SciencesPractice Patterns Physicians'FENICE InvestigatorsCIRCULATORY SHOCKintensive careddc:617RENAL REPLACEMENT THERAPYMiddle Aged3. Good healthOF-THE-LITERATURESHOCKFemalelipids (amino acids peptides and proteins)Erratumintensive care fluid therapyfluidsLife Sciences & BiomedicineCRITICALLY-ILL PATIENTSHumanCohort studymedicine.medical_specialtyCritical CareHYDROXYETHYL STARCH 130/0.4MEDLINE1117 Public Health and Health ServicesNOfluid therapyCritical Care MedicineCIRCULATORYGeneral & Internal MedicineIntensive careAnesthesiologyPATIENTSmedicinecohort studyHumansRenal replacement therapyIntensive care medicineintensive care; fluids; cohort studyPhysicians'Science & TechnologyCRITICALLY-ILLbusiness.industrySeptic shockSEPTIC SHOCK1103 Clinical Sciences3126 Surgery anesthesiology intensive care radiologymedicine.diseaseEmergency & Critical Care MedicineARTERIAL-PRESSURESEVERE SEPSISClinical trialFluid TherapyObservational studyCohort Studiebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyTASK-FORCE
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Impact of intravascular enhancement, heart rate, and calcium score on diagnostic accuracy in multislice computed tomography coronary angiography.

2005

PURPOSE: To assess the effect of intravascular enhancement, heart rate, and calcium score on diagnostic accuracy in the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). MATERIALS AND METHODS: One hundred patients (88 males; 59+/-11 years) with suspected coronary artery disease who had undergone conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA, with the following protocol: collimation 16x0.75 mm, gantry rotation time 420 ms, feed/rotation 2.8 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol 320 mgI/ml at 4 ml/s and …

MaleStatistical Female *Heart Rate Humans Male Middle Aged Retrospective Studies Sensitivity and Specificity TomographyContrast MediaCoronary DiseaseCoronary Artery DiseaseCoronary AngiographySensitivity and SpecificityHeart RateTriiodobenzoic AcidsHumanscoronary artery stenosisAgedRetrospective StudiesBody WeightCoronary StenosisCalcinosisMiddle AgedAged Artifacts Body Weight Calcinosis/*radiography Contrast Media Coronary Angiography/*methods Coronary Artery Disease/radiography Coronary Disease/*radiography Coronary Stenosis/radiography Data Interpretation; Statistical Female *Heart Rate Humans Male Middle Aged Retrospective Studies Sensitivity and Specificity Tomography; X-Ray Computed/*methods Triiodobenzoic Acids/administration & dosage/diagnostic useX-Ray Computed/*methods Triiodobenzoic Acids/administration & dosage/diagnostic useData Interpretation StatisticalAged Artifacts Body Weight Calcinosis/*radiography Contrast Media Coronary Angiography/*methods Coronary Artery Disease/radiography Coronary Disease/*radiography Coronary Stenosis/radiography Data InterpretationFemalemultislice computed tomography (MSCT)ArtifactsTomography X-Ray Computedcoronary artery stenosis; multislice computed tomography (MSCT)
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The epidemiology of back pain and its relationship with depression, psychosis, anxiety, sleep disturbances, and stress sensitivity: Data from 43 low-…

2016

Background Back pain (BP) is a leading cause of global disability. However, population-based studies investigating its impact on mental health outcomes are lacking, particularly among low- and middle-income countries (LMICs). Thus, the primary aims of this study were to: (1) determine the epidemiology of BP in 43 LMICs; (2) explore the relationship between BP and mental health (depression spectrum, psychosis spectrum, anxiety, sleep disturbances and stress). Methods Data on 190,593 community-dwelling adults aged ≥18 years from the World Health Survey (WHS) 2002–2004 were analyzed. The presence of past-12 month psychotic symptoms and depression was established using questions from the Compos…

MaleStress sensitivitySleep problemsComorbidityAnxietyGlobal Health0302 clinical medicine030212 general & internal medicinepsychosislow- and middle-income countriesDepression (differential diagnoses)Aged 80 and overSleep disordereducation.field_of_studyLow- and middle-income countriesDepressionchronic back painMiddle AgedanxietyBack pain Chronic back pain Mental health Mental illness Depression Psychosis Anxiety Sleep problems Stress sensitivity Low- and middle-income countriesmental illnessAnxiety DisordersPsychiatry and Mental healthMental illnessdepressionAnxietyMental healthFemalemedicine.symptomPsychologymental healthClinical psychologyAnxiety; Back pain; Chronic back pain; Depression; Low- and middle-income countries; Mental health; Mental illness; Psychosis; Sleep problems; Stress sensitivityAdultSleep Wake Disordersmedicine.medical_specialtyAnxiety Back pain Chronic back pain Depression Low- and middle-income countries Mental health Mental illness Psychosis Sleep problems Stress sensitivityAdolescentPopulationChronic back painBF03 medical and health sciencesYoung AdultmedicineHumansPsychiatryeducationDeveloping CountriesAgedsleep problemsDepressive Disorderstress sensitivityBack painOdds ratiomedicine.diseaseMental illnessPsychosisMental healthComorbidityPsychotic DisordersBack Pain030217 neurology & neurosurgeryStress Psychological
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Low-Frequency Therapeutic Ultrasound with Varied Duty Cycle: Effects on the Ischemic Brain and the Inner Ear

2009

Sonothrombolysis is a promising modality for acute stroke treatment. In vitro data suggest a duty cycle dependence of sonothrombolytic efficacy of low-frequency applications. The aim of our study was to examine its impact on safety issues in a rat model of middle cerebral artery occlusion. Rats were exposed to transcranial 60-kHz ultrasound with varied duty cycles. To determine effects on the inner ear, the acoustic threshold was determined in additional healthy animals (acoustic evoked potentials). A short duty cycle (20%) resulted in significant adverse effects (ischemic volume, hemorrhage, functional outcome), which was not observed in longer duty cycle (80%). Continuous-wave insonation …

MaleSubarachnoid hemorrhageAcoustics and UltrasonicsUltrasonic Therapymedicine.medical_treatmentBiophysicsIschemiaInfarctionBrain Ischemiaotorhinolaryngologic diseasesAnimalsMedicineRadiology Nuclear Medicine and imagingInner earRats WistarHearing DisordersStrokeRadiological and Ultrasound TechnologyTherapeutic ultrasoundbusiness.industryUltrasoundAuditory ThresholdInfarction Middle Cerebral Arterymedicine.diseaseRatsmedicine.anatomical_structureDuty cycleEar InnerAnesthesiabusinessUltrasound in Medicine & Biology
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Detrimental Effects of 60 kHz Sonothrombolysis in Rats with Middle Cerebral Artery Occlusion

2008

Recent studies have raised concerns about the safety of low frequency ultrasound in transcranial therapeutic application in cerebral ischemia. This study was designed to evaluate safety aspects and potential deleterious effects of low frequency, 60 kHz ultrasound in treatment of experimental middle cerebral artery occlusion (MCAO) in rats. Forty-five male Wistar rats were submitted to either temporary (90 min; groups I and II) or permanent MCAO (groups III and IV) using the suture technique. All animals received recombinant tissue plasminogen activator (rt-PA) starting 90 min after the beginning of occlusion. Groups I and III were additionally treated with 60 kHz ultrasound (time average ac…

MaleSubarachnoid hemorrhageAcoustics and UltrasonicsUltrasonic Therapymedicine.medical_treatmentBiophysicsIschemiaOcclusionmedicineAnimalsThrombolytic TherapyRadiology Nuclear Medicine and imagingRats WistarHearing DisordersStrokeCerebral HemorrhageRadiological and Ultrasound TechnologyTherapeutic ultrasoundmedicine.diagnostic_testbusiness.industryUltrasoundTemperatureInfarction Middle Cerebral ArteryMagnetic resonance imagingSubarachnoid Hemorrhagemedicine.diseaseCombined Modality TherapyMagnetic Resonance ImagingRatsTreatment OutcomeAnesthesiabusinessPerfusionUltrasound in Medicine & Biology
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