Search results for " Mimetic"

Human digital twins and cognitive mimetic

2021

Digital twins – digital models of technical systems and processes – have recently been introduced to work with complex industrial processes. Yet should such models concern only physical objects (as definitions of them often imply), or should users and other human beings also be included? Models that include people have been called human digital twins (HDTs); they facilitate more accurate analyses of technologies in practical use. The cognitive mimetic approach can be used to describe human interactions with technologies. This approach analyses human information processes such as perceiving and thinking to mimic how people process information in order to design intelligent technologies. The …

Cognitive Mimetics for Designing Intelligent Technologies

2018

Design mimetics is an important method of creation in technology design. Here, we review design mimetics as a plausible approach to address the problem of how to design generally intelligent technology. We argue that design mimetics can be conceptually divided into three levels based on the source of imitation. Biomimetics focuses on the structural similarities between systems in nature and technical solutions for solving design problems. In robotics, the sensory-motor systems of humans and animals are a source of design solutions. At the highest level, we introduce the concept of cognitive mimetics, in which the source for imitation is human information processing. We review and discuss so…

Eight-Membered Rings With Two Heteroatoms 1,5

2022

This chapter titled “Eight-membered Rings with two Heteroatoms 1,5” deals eight-membered rings with two heteroatoms in a 1,5-relationship, namely 1,5-diazocine, 1,5-oxazocine, 1,5-thiazocine, 1,5-dioxocin, 1,5-oxathiocin, and 1,5-dithiocin and covers the literature from 2007 to October 2020 (SciFindern search) reporting the chemistry of uncondensed derivatives, diheterocines fused to carbocycles and heterocycles, as well as bridged diheterocines. Among them, the 1,5-diazocine ring system is by far the largest class, based on the number of publications which constituted the 87% of the total amount of the references reported in the range of interest of CHEC IV. Thus, 1,5-diazocines were divid…

Challenge of tacit knowledge in acquiring information in cognitive mimetics

2019

Intelligent technologies are rising. This is why methods for designing them are important. One approach is to study how people process information in carrying out intelligence demanding tasks and use this information in designing new technology solutions. This approach can be called cognitive mimetics. A problem in mimetics is to explicate tacit or subconscious knowledge. Here, we study a combination of thinking aloud in ship simulator driving and focus group commenting the solutions of subjects. On the ground of these early experiments, a multiple method combination seems to be the best way forward to solve problems of tacit or subconscious knowledge. peerReviewed

BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer

2022

The heterogeneous therapy response observed in colorectal cancer is in part due to cancer stem cells (CSCs) that resist chemotherapeutic insults. The anti-apoptotic protein BCL-XL plays a critical role in protecting CSCs from cell death, where its inhibition with high doses of BH3 mimetics can induce apoptosis. Here, we screen a compound library for synergy with low-dose BCL-XL inhibitor A-1155463 to identify pathways that regulate sensitivity to BCL-XL inhibition and reveal that fibroblast growth factor receptor (FGFR)4 inhibition effectively sensitizes to A-1155463 both in vitro and in vivo. Mechanistically, we identify a rescue response that is activated upon BCL-XL inhibition and leads …

Membranes and More. Membrane-Mimetic Approach to Advanced Materials. ByJ. H. Fendler, Advances in Polymeric Science, Vol. 113, Springer, Berlin 1994,…

1995

Verbal, linguistique et langagier. Enunciazione e antropologia del gesto mentale.

2018

The paper aims to explain the metalinguistic value of three distinct but related concepts of the Theory of Predicative and Enunciative Operations (henceforth, TOPE). This research program, conceived by the french linguist Antoine Culioli, introduced a fundamental theoretical distinction between the concepts of “verbal” “linguistique” et “langagier”. The first concept refer to the complementary processes of phonation and audition that characterize every interlocutory exchange. The second one refer to the rules that characterize the formal system of a specific natural language. The third and last concept refer to the language operations viewed as processes of construction of meaning. With par…

Chemoenzymatic Synthesis of Functional Sialyl LewisX Mimetics with a Heteroaromatic Core

2014

Functional mimetics of the sialyl Lewis(X) tetrasaccharide were prepared by the enzymatic sialylation of a 1,3-diglycosylated indole and a glycosyl azide, which was subsequently transformed into a 1,4-diglycosylated 1,2,3-triazole, by using the trans-sialidase of Trypanosoma cruzi. These compounds inhibited the binding of E-, L-, and P-selectin-coated nanoparticles to polyacrylamide-bound sialyl-Lewis(X) -containing neighboring sulfated tyrosine residues (sTyr/sLe(X) -PAA) at low or sub-millimolar concentrations. Except for E-selectin, the mimetics showed higher activities than the natural tetrasaccharide.

Emerging Therapies For Raising Hdl-C And Augmenting Hdl Particle Functionality

2013

High-density lipoprotein particles are highly complex polymolecular aggregates capable of performing a remarkable range of atheroprotective functions. Considerable research is being performed throughout the world to develop novel pharmacologic approaches to: (1) promote apoprotein A-I and HDL particle biosynthesis; (2) augment capacity for reverse cholesterol transport so as to reduce risk for the development and progression of atherosclerotic disease; and (3) modulate the functionality of HDL particles in order to increase their capacity to antagonize oxidation, inflammation, thrombosis, endothelial dysfunction, insulin resistance, and other processes that participate in arterial wall inju…

Cognitive Mimetics for AI Ethics : Tacit Knowledge, Action Ontologies and Problem Restructuring

2020

Ethics and ethical information processing are an important problem for AI development. It is important for self-evident reasons, but also challenging in its’ implications and should be welcomed by designers and developers as an interesting technical challenge. This article explores AI ethics as a design problem and lays out how cognitive mimetics could be used a method for its design. AI ethics is conceptualized as a problem of implementation on the one hand, and as a problem of ethical contents on the other. From the viewpoint of human information processing, ethics becomes a special case of ethical information processing - one that has deep implications in terms of AI abilities and inform…